词条 | Exosome component 6 |
释义 |
This gene product constitutes one of the subunits of the multisubunit particle called the exosome complex, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.[3] InteractionsExosome component 6 has been shown to interact with Exosome component 7,[2]Exosome component 8[2] and Exosome component 1.[2] References1. ^{{cite journal | vauthors = Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M | title = AU binding proteins recruit the exosome to degrade ARE-containing mRNAs | journal = Cell | volume = 107 | issue = 4 | pages = 451–64 |date=Nov 2001 | pmid = 11719186 | pmc = | doi =10.1016/S0092-8674(01)00578-5 }} 2. ^1 2 3 {{cite journal | vauthors = Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ | title = Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring | journal = J Mol Biol | volume = 323 | issue = 4 | pages = 653–63 |date=Nov 2002 | pmid = 12419256 | pmc = | doi =10.1016/S0022-2836(02)00947-6 }} 3. ^1 {{cite web | title = Entrez Gene: EXOSC6 exosome component 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=118460| accessdate = }} Further reading{{refbegin | 2}}
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