| 词条 | EXP-561 |
| 释义 |
| IUPAC_name = 4-phenylbicyclo[2.2.2]octan-1-amine | image = EXPfivesixone.png | tradename = | legal_status = Uncontrolled | routes_of_administration = Oral | CAS_supplemental = 16142-83-9 (hydrochloride monohydrate) | CAS_number_Ref = {{cascite|correct|CAS}} | CAS_number = 10207-08-6 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 6S9H885MKF | ATC_prefix = none | PubChem = 27696 | ChemSpiderID = 25769 | C=14 | H=19 | N=1 | molecular_weight = 201.31 g/mol | smiles = NC12CCC(CC1)(CC2)C3=CC=CC=C3 }}EXP-561[1] is an investigational drug that acts as an inhibitor of the reuptake of serotonin, dopamine, and norepinephrine.[2][3][4][5] It was developed in the 1960s by Du Pont[6] and was suggested as a potential antidepressant but failed in trials[7] and was never marketed.[5][8][9][10] References1. ^US 3362878 - Pharmaceutical compositions and methods utilizing substituted bicyclo[2.2.2]-octanes {{Stimulants}}{{Antidepressants}}{{Monoamine reuptake inhibitors}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Fuller RW, Snoddy HD, Perry KW | title = Inhibition of amine uptake by 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561) in rats | journal = Biochemical Pharmacology | volume = 25 | issue = 21 | pages = 2409–10 |date=November 1976 | pmid = 999731 | doi = 10.1016/0006-2952(76)90039-3| url = http://linkinghub.elsevier.com/retrieve/pii/0006-2952(76)90039-3}} 3. ^{{cite journal | author = Koe BK | title = Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 199 | issue = 3 | pages = 649–61 |date=December 1976 | pmid = 994022 | doi = | url = http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=994022}} 4. ^{{cite journal |vauthors=Wong DT, Molloy BB, Bymaster FP | title = Blockade of monoamine uptake by 1-amino-4-phenylbicyclo(2,2,2)octane (EXP 561) in rat brain and heart | journal = Neuropharmacology | volume = 16 | issue = 1 | pages = 11–5 |date=January 1977 | pmid = 834358 | doi = 10.1016/0028-3908(77)90040-5| url = }} 5. ^1 {{cite journal |vauthors=Maj J, Skuza G, Sowińska H, Nowak G | title = Pharmacological properties of EXP 561, a potential antidepressant drug | journal = Journal of Neural Transmission | volume = 70 | issue = 1-2 | pages = 81–97 | year = 1987 | pmid = 2822850 | doi = 10.1007/BF01252511| url = }} 6. ^US Patent 3308160 - PHENYLBICYCLO[Z.Z.Z]OCTANE-L-AMINES AND SALTS THEREOF 7. ^INTERNATIONAL REVIEW NEUROBIOLOGY, Volume 12 Page 160 8. ^{{cite journal |vauthors=Lehmann HE, Ban TA, Debow SL | title = A clinical-pharmacological study with EXP 561 | journal = Current Therapeutic Research, Clinical and Experimental | volume = 9 | issue = 6 | pages = 306–8 |date=June 1967 | pmid = 4963065 | doi = | url = }} 9. ^{{cite journal |vauthors=Gershon S, Hekimian LJ, Floyd A | title = Non-correlation of preclinical-clinical evaluation of a prosposed anti-depressant 4-phenyl-bicyclo(2,2,2)octan-1-amine hydrochloride monohydrate (EXP 561) | journal = Arzneimittel-Forschung | volume = 18 | issue = 2 | pages = 243–5 |date=February 1968 | pmid = 5695389 | doi = | url = }} 10. ^{{cite journal |vauthors=Ross SB, Kelder D | title = Inhibition of 3H-dopamine accumulation in reserpinized and normal rat striatum | journal = Acta Pharmacologica et Toxicologica | volume = 44 | issue = 5 | pages = 329–35 |date=May 1979 | pmid = 474143 | doi = 10.1111/j.1600-0773.1979.tb02339.x| url = }} 5 : Amines|Antidepressants|Serotonin-norepinephrine-dopamine reuptake inhibitors|Stimulants|Experimental drugs |
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