“Ionomycin”的意思、由来-开放百科全书

词条

Ionomycin

释义

References

{{chembox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 400118302
| ImageFile=Ionomycin (free acid).svg
| ImageSize=300
| IUPACName=(4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-Dihydroxy-22(2S,2′R,5S,5′S)-5′-[(1R)-1-hydroxyethyl]-2,5′-dimethyloctahydro-2,2′-bifuran-5-yl4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoic acid
| OtherNames=
|Section1={{Chembox Identifiers
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 501617
| ChEMBL2_Ref = {{ebicite|changed|EBI}}
| ChEMBL2 = 1222121
| PubChem = 6912226
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID = 5288579
| SMILES = C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\\O
| InChI = 1/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
| InChIKey = PGHMRUGBZOYCAA-ADZNBVRBBY
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C41H72O9/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47)/b13-11+,34-24-/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = PGHMRUGBZOYCAA-ADZNBVRBSA-N
| CASNo_Ref = {{cascite|correct|??}}
| CASNo = 56092-81-0
}}
|Section2={{Chembox Properties
| C=41 | H=72 | O=9
| MolarMass=709.0050
| Appearance=
| Density=
| MeltingPt=
| BoilingPt=
| Solubility=
|Section3={{Chembox Hazards
| MainHazards=
| FlashPt=
| AutoignitionPt =
}}

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus.^[1] It is used in research to raise the intracellular level of calcium (Ca²⁺) and as a research tool to understand Ca²⁺ transport across biological membranes.

It is also used to stimulate the intracellular production of the following cytokines; interferon, perforin, IL-2, and IL-4 - usually in conjunction with PMA. These cytokines are important in the inflammatory response.

Commercially, Ionomycin can be obtained as a free acid, or as a Ca²⁺ salt.

References

1. ^See Ionomycin Calcium salt {{webarchive|url=https://web.archive.org/web/20060626052220/http://www.fermentek.co.il/ionomycin_CA_salt.htm |date=2006-06-26 }} from Fermentek, manufacturer's product page for ionomycin

1 : Ionophores

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