“Extraction ratio”的意思、由来-开放百科全书

词条

Extraction ratio

释义

References

Extraction ratio is a measure in renal physiology, primarily used to calculate renal plasma flow in order to evaluate renal function. It measures the percentage of the compound entering the kidney that was excreted into the final urine.^[1]

Measured in concentration in blood plasma, it may thus be expressed as:

, where P_a is the concentration in renal artery, and P_v is the concentration in the renal vein.

For instance, para aminohippuric acid (PAH) is almost completely excreted in the final urine, and thus almost none is found in the venous return (P_v ~0). Therefore, the extraction ratio of PAH ~1. This is why PAH is used in PAH clearance to estimate renal plasma flow.

Note: The "Hepatic Extraction Ratio" is a similar measurement for clearance of a substance(usually a pharmacological drug) by the liver. It is defined as the fraction of drug removed from blood by the liver, and depends on 3 factors— the hepatic blood flow, the uptake into the hepatocytes, and the enzyme metabolic capacity. Examples of drugs with a high hepatic extraction ratio include propranolol, opiates, and lignocaine

References

1. ^Renal Mathematics Texas Tech University Health Sciences Center

1 : Renal physiology

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