“EYA2”的意思、由来-开放百科全书

Function

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Five transcript variants encoding three distinct isoforms have been identified for this gene.^[2]

References

1. ^{{cite journal | vauthors = Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, Weil D, Cruaud C, Sahly I, Leibovici M, Bitner-Glindzicz M, Francis M, Lacombe D, Vigneron J, Charachon R, Boven K, Bedbeder P, Van Regemorter N, Weissenbach J, Petit C | title = A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family | journal = Nature Genetics | volume = 15 | issue = 2 | pages = 157–64 | date = Feb 1997 | pmid = 9020840 | pmc = | doi = 10.1038/ng0297-157 }}
2. ^¹{{cite web | title = Entrez Gene: EYA2 eyes absent homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2139| accessdate = }}
3. ^¹{{cite journal | vauthors = Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR | title = The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 41 | pages = 32129–34 | date = Oct 2000 | pmid = 10906137 | doi = 10.1074/jbc.M004577200 }}

Further reading

{{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = Apr 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}

{{cite journal | vauthors = Zimmerman JE, Bui QT, Steingrímsson E, Nagle DL, Fu W, Genin A, Spinner NB, Copeland NG, Jenkins NA, Bucan M, Bonini NM | title = Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene | journal = Genome Research | volume = 7 | issue = 2 | pages = 128–41 | date = Feb 1997 | pmid = 9049631 | doi = 10.1101/gr.7.2.128 }}

{{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = Apr 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}

{{cite journal | vauthors = Duncan MK, Kos L, Jenkins NA, Gilbert DJ, Copeland NG, Tomarev SI | title = Eyes absent: a gene family found in several metazoan phyla | journal = Mammalian Genome | volume = 8 | issue = 7 | pages = 479–85 | date = Jul 1997 | pmid = 9195991 | doi = 10.1007/s003359900480 | url = https://zenodo.org/record/1232683/files/article.pdf }}

{{cite journal | vauthors = Borsani G, DeGrandi A, Ballabio A, Bulfone A, Bernard L, Banfi S, Gattuso C, Mariani M, Dixon M, Donnai D, Metcalfe K, Winter R, Robertson M, Axton R, Brown A, van Heyningen V, Hanson I | title = EYA4, a novel vertebrate gene related to Drosophila eyes absent | journal = Human Molecular Genetics | volume = 8 | issue = 1 | pages = 11–23 | date = Jan 1999 | pmid = 9887327 | doi = 10.1093/hmg/8.1.11 }}

{{cite journal | vauthors = Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR | title = The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 41 | pages = 32129–34 | date = Oct 2000 | pmid = 10906137 | doi = 10.1074/jbc.M004577200 }}

{{cite journal | vauthors = Clark SW, Fee BE, Cleveland JL | title = Misexpression of the eyes absent family triggers the apoptotic program | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3560–7 | date = Feb 2002 | pmid = 11700312 | doi = 10.1074/jbc.M108410200 }}

{{cite journal | vauthors = Fee BE, Doyle CA, Cleveland JL | title = A novel Eyes Absent 2 protein is expressed in the human eye | journal = Gene | volume = 285 | issue = 1-2 | pages = 221–8 | date = Feb 2002 | pmid = 12039049 | doi = 10.1016/S0378-1119(02)00404-3 }}

{{cite journal | vauthors = Fougerousse F, Durand M, Lopez S, Suel L, Demignon J, Thornton C, Ozaki H, Kawakami K, Barbet P, Beckmann JS, Maire P | title = Six and Eya expression during human somitogenesis and MyoD gene family activation | journal = Journal of Muscle Research and Cell Motility | volume = 23 | issue = 3 | pages = 255–64 | year = 2003 | pmid = 12500905 | doi = 10.1023/A:1020990825644 }}

{{cite journal | vauthors = Zhang L, Yang N, Huang J, Buckanovich RJ, Liang S, Barchetti A, Vezzani C, O'Brien-Jenkins A, Wang J, Ward MR, Courreges MC, Fracchioli S, Medina A, Katsaros D, Weber BL, Coukos G | title = Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth | journal = Cancer Research | volume = 65 | issue = 3 | pages = 925–32 | date = Feb 2005 | pmid = 15705892 | doi = }}

{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}

Function

Interactions

References

Further reading