| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene.[1][2]This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.[2] References1. ^{{cite journal | vauthors = Rodova M, Ankilova V, Safro MG | title = Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells | journal = Biochem Biophys Res Commun | volume = 255 | issue = 3 | pages = 765–73 |date=Apr 1999 | pmid = 10049785 | pmc = | doi = 10.1006/bbrc.1999.0141 }}
2. ^1 {{cite web | title = Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10056| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Archambault de Vencay J, Thomes JC, Julien R |title=Phenylalanyl-tRNA synthetase of the human placenta. Evidence for different enzymatic forms in equilibrium |journal=FEBS Lett. |volume=89 |issue= 1 |pages= 98–102 |year= 1978 |pmid= 658405 |doi=10.1016/0014-5793(78)80531-6 }}
- {{cite journal | vauthors=Nazarenko IA, Peterson ET, Zakharova OD |title=Recognition nucleotides for human phenylalanyl-tRNA synthetase |journal=Nucleic Acids Res. |volume=20 |issue= 3 |pages= 475–8 |year= 1992 |pmid= 1741281 |doi=10.1093/nar/20.3.475 | pmc=310410 |display-authors=etal}}
- {{cite journal | vauthors=Sen S, Zhou H, Ripmaster T |title=Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6164–9 |year= 1997 |pmid= 9177188 |doi=10.1073/pnas.94.12.6164 | pmc=21020 |display-authors=etal}}
- {{cite journal | vauthors=Zhou X, Richon VM, Ngo L |title=Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation |journal=Gene |volume=233 |issue= 1–2 |pages= 13–9 |year= 1999 |pmid= 10375616 |doi=10.1016/S0378-1119(99)00170-5 |display-authors=etal}}
- {{cite journal | vauthors=Zhang QH, Ye M, Wu XY |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200 | pmc=310934 |display-authors=etal}}
- {{cite journal | vauthors=Moor N, Linshiz G, Safro M |title=Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes |journal=Protein Expr. Purif. |volume=24 |issue= 2 |pages= 260–7 |year= 2002 |pmid= 11858721 |doi= 10.1006/prep.2001.1560 }}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Moor N, Lavrik O, Favre A, Safro M |title=Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end |journal=Biochemistry |volume=42 |issue= 36 |pages= 10697–708 |year= 2003 |pmid= 12962494 |doi= 10.1021/bi034732q }}
- {{cite journal | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal | vauthors=Yu XY, Finn J, Hill JM |title=A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases |journal=Bioorg. Med. Chem. Lett. |volume=14 |issue= 5 |pages= 1339–42 |year= 2004 |pmid= 14980694 |doi= 10.1016/j.bmcl.2003.11.081 |display-authors=etal}}
- {{cite journal | vauthors=Vasil'eva IA, Bogachev VS, Favre A |title=Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase |journal=Biochemistry Mosc. |volume=69 |issue= 2 |pages= 143–53 |year= 2005 |pmid= 15000680 |doi=10.1023/B:BIRY.0000018944.53390.44 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
{{refend}}External links- {{UCSC genome browser|FARSB}}
- {{UCSC gene details|FARSB}}
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