“Fast statistical alignment”的意思、由来-开放百科全书

词条

Fast statistical alignment

释义

Input/Output
References
External links

{{Infobox Software|name=FSA|developer=Robert Bradley (UC Berkeley), Colin Dewey (UW Madison), Lior Pachter (UC Berkeley)|latest_release_version=1.5.2|operating_system=UNIX, Linux, Mac|genre=Bioinformatics tool|licence=Open source}}

FSA is a multiple sequence alignment program for aligning many proteins or RNAs or long genomic DNA sequences. Along with MUSCLE and MAFFT, FSA is one of the few sequence alignment programs which can align datasets of hundreds or thousands of sequences. FSA uses a different optimization criterion which allows it to more reliably identify non-homologous sequences than these other programs, although this increased accuracy comes at the cost of decreased speed.

FSA is currently being used for projects including sequencing new worm genomes and analyzing in vivo transcription factor binding in flies.

Input/Output

This program accepts sequences in FASTA format and outputs alignments in FASTA format or Stockholm format.

References

{{cite journal|vauthors=Bradley RK, Roberts A, Smoot M, Juvekar S, Do J, Dewey C, Holmes I, Pachter L|author8-link=Lior Pachter|date=2009|title=Fast Statistical Alignment|journal=PLoS Computational Biology |volume=5|issue=5|pages=e1000392|doi=10.1371/journal.pcbi.1000392|pmid=19478997|pmc=2684580|bibcode=2009PLSCB...5E0392B}}

External links

[https://web.archive.org/web/20090430184649/http://orangutan.math.berkeley.edu/fsa/ FSA web server]
FSA source code

1 : Bioinformatics

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