| 词条 | Fenclofenac |
| 释义 |
| ImageFile = Fenclofenac.png | ImageSize = | ImageAlt = | IUPACName = | OtherNames = |Section1={{Chembox Identifiers | UNII_Ref = {{fdacite|correct|FDA}} | UNII = Y01JW64D01 | ChEMBL = 15677 | CASNo = 34645-84-6 | PubChem = 65394 | ChemSpiderID = 58860 | InChI = 1/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18) | InChIKey = IDKAXRLETRCXKS-UHFFFAOYAG | StdInChI = 1S/C14H10Cl2O3/c15-10-5-6-13(11(16)8-10)19-12-4-2-1-3-9(12)7-14(17)18/h1-6,8H,7H2,(H,17,18) | StdInChIKey = IDKAXRLETRCXKS-UHFFFAOYSA-N | SMILES = OC(=O)Cc1ccccc1Oc2ccc(Cl)cc2Cl}} |Section2={{Chembox Properties | Formula = C14 H10 Cl2 O3 | MolarMass = 297.1 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Fenclofenac is a nonsteroidal anti-inflammatory drug (NSAID) previously used in rheumatism. It has mild immunosuppressive effects[1] and may displace thyroid hormone from its binding protein.[2][3] It can also cause lichen planus.[4] Due to its side effects it was withdrawn from the UK and US in the 1980s. References1. ^{{cite journal |vauthors=Spiers EM, Watson NT, Beck JS, Chapman IV, Dettmar PW |title=The effect of fenclofenac on the regeneration of lymphocytes in rats following total body irradiation |journal=Int. J. Immunopharmacol. |volume=15 |issue=8 |pages=865–9 |date=November 1993 |pmid=7902830 |doi= 10.1016/0192-0561(93)90003-h|url=}} {{NSAIDs}}{{Topical products for joint and muscular pain}}{{Prostanoidergics}}{{musculoskeletal-drug-stub}}{{analgesic-stub}}2. ^{{cite journal |vauthors=Allen PA, Taylor RT |title=Fenclofenac and thyroid function tests |journal=Br Med J |volume=281 |issue=6255 |pages=1642 |date=December 1980 |pmid=7448557 |pmc=1715072 |doi= 10.1136/bmj.281.6255.1642}} 3. ^{{cite journal |vauthors=Taylor R, Clark F, Griffiths ID, Weeke J |title=Prospective study of effect of fenclofenac on thyroid function tests |journal=Br Med J |volume=281 |issue=6245 |pages=911–2 |date=October 1980 |pmid=7427506 |pmc=1714224 |doi= 10.1136/bmj.281.6245.911}} 4. ^{{cite journal |vauthors=Ferguson MM, Wiesenfeld D, MacDonald DG |title=Oral mucosal lichenoid eruption due to fenclofenac |journal=J Oral Med |volume=39 |issue=1 |pages=39–40 |year=1984 |pmid=6232357 |doi= |url=}} 1 : Nonsteroidal anti-inflammatory drugs |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。