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词条 FERMT2
释义

  1. Function

  2. Interactions

  3. Role in health and diseases

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}Fermitin family homolog 2 (FERMT2) also known as pleckstrin homology domain-containing family C member 1 (PLEKHC1) or kindlin-2 is a protein that in humans is encoded by the FERMT2 gene.[1][2][3]

Kindlin-2 is the first of the kindlin protein to be discovered in 1994. It was detected in a screen for epidermal growth factor (EGF)-induced mRNAs and initially named mitogen-inducible gene 2 (Mig-2) protein.[1]

Function

FERMT2 is a component of extracellular matrix structures in mammalian cells and is required for proper control of cell shape change.[4]

A major task of kindlins is to regulate the activation of integrins.[5]

Interactions

FERMT2 has been shown to interact with FBLIM1.[4]

Role in health and diseases

  • Loss of kindlin-2 in mice leads to peri-implantation lethality.[6]
  • Kindlin-2 is highly expressed in activated myofibroblasts for regulation of focal adhesion formation.[7]
  • Elevated kindlin-2 expression was observed in tubular intestinal fibrosis of the kidney, a condition is characterized by massive expansion of the cortical interstitium, conversion of fibroblasts into myofibroblasts and progressive EMT of tubular epithelial cells.[8]
  • Kindlin-2 is required for angiogenesis and blood vessel homeostasis.[9]
  • Kindlin-2 can exert tumor-promoting or tumor-inhibiting functions based on tumor-type-dependent.[10]

References

1. ^1 {{cite journal | vauthors = Wick M, Bürger C, Brüsselbach S, Lucibello FC, Müller R | title = Identification of serum-inducible genes: different patterns of gene regulation during G0-->S and G1-->S progression | journal = Journal of Cell Science | volume = 107 ( Pt 1) | issue = 1 | pages = 227–39 | date = January 1994 | pmid = 8175911 | doi = | url = http://jcs.biologists.org/cgi/content/abstract/107/1/227 }}
2. ^{{cite journal | vauthors = Weinstein EJ, Bourner M, Head R, Zakeri H, Bauer C, Mazzarella R | title = URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas | journal = Biochimica et Biophysica Acta | volume = 1637 | issue = 3 | pages = 207–16 | date = April 2003 | pmid = 12697302 | doi = 10.1016/S0925-4439(03)00035-8 }}
3. ^{{cite web | title = Entrez Gene: FERMT2 | url =https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10979 | access-date = }}
4. ^1 {{cite journal | vauthors = Tu Y, Wu S, Shi X, Chen K, Wu C | title = Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation | journal = Cell | volume = 113 | issue = 1 | pages = 37–47 | date = April 2003 | pmid = 12679033 | doi = 10.1016/S0092-8674(03)00163-6 }}
5. ^{{cite journal | vauthors = Rognoni E, Ruppert R, Fässler R | title = The kindlin family: functions, signaling properties and implications for human disease | journal = Journal of Cell Science | volume = 129 | issue = 1 | pages = 17–27 | date = January 2016 | pmid = 26729028 | doi = 10.1242/jcs.161190 }}
6. ^{{cite journal | vauthors = Montanez E, Ussar S, Schifferer M, Bösl M, Zent R, Moser M, Fässler R | title = Kindlin-2 controls bidirectional signaling of integrins | journal = Genes & Development | volume = 22 | issue = 10 | pages = 1325–30 | date = May 2008 | pmid = 18483218 | pmc = 2377186 | doi = 10.1101/gad.469408 }}
7. ^{{cite journal | vauthors = He Y, Esser P, Schacht V, Bruckner-Tuderman L, Has C | title = Role of kindlin-2 in fibroblast functions: implications for wound healing | journal = The Journal of Investigative Dermatology | volume = 131 | issue = 1 | pages = 245–56 | date = January 2011 | pmid = 20861856 | doi = 10.1038/jid.2010.273 }}
8. ^{{cite journal | vauthors = Bielesz B, Sirin Y, Si H, Niranjan T, Gruenwald A, Ahn S, Kato H, Pullman J, Gessler M, Haase VH, Susztak K | title = Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans | journal = The Journal of Clinical Investigation | volume = 120 | issue = 11 | pages = 4040–54 | date = November 2010 | pmid = 20978353 | pmc = 2964979 | doi = 10.1172/JCI43025 }}
9. ^{{cite journal | vauthors = Pluskota E, Dowling JJ, Gordon N, Golden JA, Szpak D, West XZ, Nestor C, Ma YQ, Bialkowska K, Byzova T, Plow EF | title = The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish | journal = Blood | volume = 117 | issue = 18 | pages = 4978–87 | date = May 2011 | pmid = 21378273 | pmc = 3100704 | doi = 10.1182/blood-2010-11-321182 | url = http://www.bloodjournal.org/cgi/doi/10.1182/blood-2010-11-321182 }}
10. ^{{cite journal | vauthors = Zhan J, Zhang H | title = Kindlins: Roles in development and cancer progression | journal = The International Journal of Biochemistry & Cell Biology | volume = 98 | pages = 93–103 | date = May 2018 | pmid = 29544897 | doi = 10.1016/j.biocel.2018.03.008 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Kato K, Shiozawa T, Mitsushita J, Toda A, Horiuchi A, Nikaido T, Fujii S, Konishi I | title = Expression of the mitogen-inducible gene-2 (mig-2) is elevated in human uterine leiomyomas but not in leiomyosarcomas | journal = Human Pathology | volume = 35 | issue = 1 | pages = 55–60 | date = January 2004 | pmid = 14745725 | doi = 10.1016/j.humpath.2003.08.019 }}
  • {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
  • {{cite journal | vauthors = Wang L, Deng W, Shi T, Ma D | title = URP2SF, a FERM and PH domain containing protein, regulates NF-kappaB and apoptosis | journal = Biochemical and Biophysical Research Communications | volume = 368 | issue = 4 | pages = 899–906 | date = April 2008 | pmid = 18280249 | doi = 10.1016/j.bbrc.2008.02.024 }}
{{refend}}

External links

  • FERMT2 Info with links in the Cell Migration Gateway
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