“FGF18”的意思、由来-开放百科全书

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis ^[4] and has been shown to cause thickening of cartilage in a murine model of osteoarthritis,^[5] and the recombinant version of it (sprifermin) will soon enter trials as a potential treatment for osteoarthritis.^[6] Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.^[3]

References

1. ^{{cite journal |vauthors=Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N | title = Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18 | journal = J Biol Chem | volume = 273 | issue = 29 | pages = 18161–4 |date=Aug 1998 | pmid = 9660775 | pmc = | doi =10.1074/jbc.273.29.18161 }}
2. ^{{cite journal |vauthors=Hu MC, Qiu WR, Wang YP, Hill D, Ring BD, Scully S, Bolon B, DeRose M, Luethy R, Simonet WS, Arakawa T, Danilenko DM | title = FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation | journal = Mol Cell Biol | volume = 18 | issue = 10 | pages = 6063–74 |date=Nov 1998 | pmid = 9742123 | pmc = 109192 | doi = 10.1128/MCB.18.10.6063}}
3. ^¹{{cite web | title = Entrez Gene: FGF18 fibroblast growth factor 18| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8817| accessdate = }}
4. ^{{Cite journal | last1 = Davidson | first1 = D. | last2 = Blanc | first2 = A. | last3 = Filion | first3 = D. | last4 = Wang | first4 = H. | last5 = Plut | first5 = P. | last6 = Pfeffer | first6 = G. | last7 = Buschmann | first7 = M. D. | last8 = Henderson | first8 = J. E. | doi = 10.1074/jbc.M410148200 | title = Fibroblast Growth Factor (FGF) 18 Signals through FGF Receptor 3 to Promote Chondrogenesis | journal = Journal of Biological Chemistry | volume = 280 | issue = 21 | pages = 20509–20515 | year = 2005 | pmid = 15781473| pmc = }}
5. ^{{Cite journal | last1 = Moore | first1 = E. | last2 = Bendele | first2 = A. | last3 = Thompson | first3 = D. | last4 = Littau | first4 = A. | last5 = Waggie | first5 = K. | last6 = Reardon | first6 = B. | last7 = Ellsworth | first7 = J. | doi = 10.1016/j.joca.2005.03.003 | title = Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis | journal = Osteoarthritis and Cartilage | volume = 13 | issue = 7 | pages = 623–631 | year = 2005 | pmid = 15896984| pmc = }}
6. ^{{citation|url=http://www.merckgroup.com/en/media/extNewsDetail.html?newsId=502569FC1F1AFE50C1257B2F00538E80&newsType=1|accessdate=2013-04-02|title=Merck Announces Collaboration With Nordic Bioscience for Sprifermin in Osteoarthritis of the Knee}}

Further reading

{{cite journal |vauthors=Haque T, Nakada S, Hamdy RC |title=A review of FGF18: Its expression, signaling pathways and possible functions during embryogenesis and post-natal development |journal=Histol. Histopathol. |volume=22 |issue= 1 |pages= 97–105 |year= 2007 |pmid= 17128416 |doi= }}

{{cite journal |vauthors=Hu MC, Wang YP, Qiu WR |title=Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to chromosome 14p11 |journal=Oncogene |volume=18 |issue= 16 |pages= 2635–42 |year= 1999 |pmid= 10353607 |doi= 10.1038/sj.onc.1202616 }}

{{cite journal |vauthors=Xu J, Liu Z, Ornitz DM |title=Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures |journal=Development |volume=127 |issue= 9 |pages= 1833–43 |year= 2000 |pmid= 10751172 |doi= }}

{{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}

{{cite journal | author=Whitmore TE |title=Assignment of fibroblast growth factor 18 (FGF18) to human chromosome 5q34 by use of radiation hybrid mapping and fluorescence in situ hybridization |journal=Cytogenet. Cell Genet. |volume=90 |issue= 3–4 |pages= 231–3 |year= 2001 |pmid= 11124520 |doi=10.1159/000056775 |name-list-format=vanc| author2=Maurer MF | author3=Sexson S | display-authors=3 | last4=Raymond | first4=F. | last5=Conklin | first5=D. | last6=Deisher | first6=T.A. }}

{{cite journal | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 |name-list-format=vanc| author2=Wellenreuther R | author3=Poustka A | display-authors=3 | last4=Pepperkok | first4=R | last5=Wiemann | first5=S }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Clark HF |title=The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 |name-list-format=vanc| author2=Gurney AL | author3=Abaya E | display-authors=3 | last4=Baker | first4=K | last5=Baldwin | first5=D | last6=Brush | first6=J | last7=Chen | first7=J | last8=Chow | first8=B | last9=Chui | first9=C }}

{{cite journal |vauthors=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9 |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200 }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |name-list-format=vanc| author2=Arlt D | author3=Huber W | display-authors=3 | last4=Wellenreuther | first4=R | last5=Schleeger | first5=S | last6=Mehrle | first6=A | last7=Bechtel | first7=S | last8=Sauermann | first8=M | last9=Korf | first9=U }}

{{cite journal |vauthors=Cormier S, Leroy C, Delezoide AL, Silve C |title=Expression of fibroblast growth factors 18 and 23 during human embryonic and fetal development |journal=Gene Expr. Patterns |volume=5 |issue= 4 |pages= 569–73 |year= 2005 |pmid= 15749088 |doi= 10.1016/j.modgep.2004.10.008 }}

{{cite journal | author=Antoine M |title=Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells |journal=Growth Factors |volume=23 |issue= 2 |pages= 87–95 |year= 2005 |pmid= 16019430 |doi= 10.1080/08977190500096004 |name-list-format=vanc| author2=Wirz W | author3=Tag CG | display-authors=3 | last4=Mavituna | first4=M. | last5=Emans | first5=N. | last6=Korff | first6=T. | last7=Stoldt | first7=V. | last8=Gressner | first8=A. M. | last9=Kiefer | first9=P. }}

{{cite journal | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |name-list-format=vanc| author2=Rosenfelder H | author3=Schupp I | display-authors=3 | last4=Del Val | first4=C | last5=Arlt | first5=D | last6=Hahne | first6=F | last7=Bechtel | first7=S | last8=Simpson | first8=J | last9=Hofmann | first9=O }}

{{cite journal | author=Antoine M |title=Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but not proliferation |journal=Biochem. Biophys. Res. Commun. |volume=346 |issue= 1 |pages= 224–33 |year= 2006 |pmid= 16756958 |doi= 10.1016/j.bbrc.2006.05.105 |name-list-format=vanc| author2=Wirz W | author3=Tag CG | display-authors=3 | last4=Gressner | first4=A.M. | last5=Wycislo | first5=M. | last6=Müller | first6=R. | last7=Kiefer | first7=P. }}

{{cite journal | author=Riley BM |title=Impaired FGF signaling contributes to cleft lip and palate |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 11 |pages= 4512–7 |year= 2007 |pmid= 17360555 |doi= 10.1073/pnas.0607956104 | pmc=1810508 |name-list-format=vanc| author2=Mansilla MA | author3=Ma J | display-authors=3 | last4=Daack-Hirsch | first4=S. | last5=Maher | first5=B. S. | last6=Raffensperger | first6=L. M. | last7=Russo | first7=E. T. | last8=Vieira | first8=A. R. | last9=Dode | first9=C. }}