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词条 FGR (gene)
释义

  1. Function

  2. Discovery

  3. Interactions

  4. References

  5. Further reading

{{Infobox_gene}}Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a protein which in humans is encoded by the FGR gene.[1][2]

Function

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristoylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]

Discovery

The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.[3]

Interactions

FGR (gene) has been shown to interact with Wiskott-Aldrich syndrome protein.[4][5][6]

References

1. ^{{cite journal | vauthors = Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC | title = of Sciences of the United States of America | volume = 82 | issue = 19 | pages = 6595–9 | date = Oct 1985 | pmid = 2995972 | pmc = 391256 | doi = 10.1073/pnas.82.19.6595 }}
2. ^1 {{cite web | title = Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2268| accessdate = }}
3. ^{{cite journal | vauthors = Rasheed S, Barbacid M, Aaronson S, Gardner MB | title = Origin and biological properties of a new feline sarcoma virus | journal = Virology | volume = 117 | issue = 1 | pages = 238–44 | date = Feb 1982 | pmid = 6175084 | doi = 10.1016/0042-6822(82)90522-0 }}
4. ^{{cite journal | vauthors = Banin S, Truong O, Katz DR, Waterfield MD, Brickell PM, Gout I | title = Wiskott-Aldrich syndrome protein (WASp) is a binding partner for c-Src family protein-tyrosine kinases | journal = Current Biology | volume = 6 | issue = 8 | pages = 981–8 | date = Aug 1996 | pmid = 8805332 | doi = 10.1016/S0960-9822(02)00642-5 }}
5. ^{{cite journal | vauthors = Finan PM, Soames CJ, Wilson L, Nelson DL, Stewart DM, Truong O, Hsuan JJ, Kellie S | title = Identification of regions of the Wiskott-Aldrich syndrome protein responsible for association with selected Src homology 3 domains | journal = The Journal of Biological Chemistry | volume = 271 | issue = 42 | pages = 26291–5 | date = Oct 1996 | pmid = 8824280 | doi = 10.1074/jbc.271.42.26291 }}
6. ^{{cite journal | vauthors = Rivero-Lezcano OM, Marcilla A, Sameshima JH, Robbins KC | title = Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains | journal = Molecular and Cellular Biology | volume = 15 | issue = 10 | pages = 5725–31 | date = Oct 1995 | pmid = 7565724 | pmc = 230823 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Patel M, Faulkner L, Katz DR, Brickell PM | title = The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages | journal = Pathobiology | volume = 59 | issue = 4 | pages = 289–92 | year = 1991 | pmid = 1652975 | doi = 10.1159/000163665 }}
  • {{cite journal | vauthors = Resh MD | title = Myristylation and palmitylation of Src family members: the fats of the matter | journal = Cell | volume = 76 | issue = 3 | pages = 411–3 | date = Feb 1994 | pmid = 8313462 | doi = 10.1016/0092-8674(94)90104-X }}
  • {{cite journal | vauthors = Lowell CA, Berton G | title = Integrin signal transduction in myeloid leukocytes | journal = Journal of Leukocyte Biology | volume = 65 | issue = 3 | pages = 313–20 | date = Mar 1999 | pmid = 10080533 | doi = }}
  • {{cite journal | vauthors = Snapper SB, Rosen FS | title = The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization | journal = Annual Review of Immunology | volume = 17 | issue = 1 | pages = 905–29 | year = 1999 | pmid = 10358777 | doi = 10.1146/annurev.immunol.17.1.905 }}
  • {{cite journal | vauthors = Tatosyan AG, Mizenina OA | title = Kinases of the Src family: structure and functions | journal = Biochemistry. Biokhimiia | volume = 65 | issue = 1 | pages = 49–58 | date = Jan 2000 | pmid = 10702640 | doi = }}
  • {{cite journal | vauthors = Patel MS, Mankoo BS, Brickell PM | title = A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1 | journal = Human Molecular Genetics | volume = 1 | issue = 1 | pages = 65 | date = Apr 1992 | pmid = 1339476 | doi = 10.1093/hmg/1.1.65-a }}
  • {{cite journal | vauthors = Link DC, Gutkind SJ, Robbins KC, Ley TJ | title = Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter | journal = Oncogene | volume = 7 | issue = 5 | pages = 877–84 | date = May 1992 | pmid = 1373875 | doi = }}
  • {{cite journal | vauthors = Patel M, Leevers SJ, Brickell PM | title = Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites | journal = Oncogene | volume = 5 | issue = 2 | pages = 201–6 | date = Feb 1990 | pmid = 1690869 | doi = }}
  • {{cite journal | vauthors = Biondi A, Paganin C, Rossi V, Benvestito S, Perlmutter RM, Mantovani A, Allavena P | title = Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells | journal = European Journal of Immunology | volume = 21 | issue = 3 | pages = 843–6 | date = Mar 1991 | pmid = 1826268 | doi = 10.1002/eji.1830210348 }}
  • {{cite journal | vauthors = Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC | title = A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes | journal = Molecular and Cellular Biology | volume = 11 | issue = 3 | pages = 1500–7 | date = Mar 1991 | pmid = 1847500 | pmc = 369433 | doi = }}
  • {{cite journal | vauthors = Patel M, Leevers SJ, Brickell PM | title = Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines | journal = International Journal of Cancer | volume = 45 | issue = 2 | pages = 342–6 | date = Feb 1990 | pmid = 2154410 | doi = 10.1002/ijc.2910450222 }}
  • {{cite journal | vauthors = Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM | title = Isolation of duplicated human c-src genes located on chromosomes 1 and 20 | journal = Molecular and Cellular Biology | volume = 5 | issue = 4 | pages = 831–8 | date = Apr 1985 | pmid = 2581127 | pmc = 366788 | doi = }}
  • {{cite journal | vauthors = Brickell PM, Patel M | title = Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines | journal = British Journal of Cancer | volume = 58 | issue = 6 | pages = 704–9 | date = Dec 1988 | pmid = 2852026 | pmc = 2246855 | doi = 10.1038/bjc.1988.294 }}
  • {{cite journal | vauthors = Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC | title = Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 82 | issue = 19 | pages = 6595–9 | date = Oct 1985 | pmid = 2995972 | pmc = 391256 | doi = 10.1073/pnas.82.19.6595 }}
  • {{cite journal | vauthors = Cheah MS, Ley TJ, Tronick SR, Robbins KC | title = fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection | journal = Nature | volume = 319 | issue = 6050 | pages = 238–40 | year = 1986 | pmid = 3003578 | doi = 10.1038/319238a0 }}
  • {{cite journal | vauthors = Nishizawa M, Semba K, Yoshida MC, Yamamoto T, Sasaki M, Toyoshima K | title = Structure, expression, and chromosomal location of the human c-fgr gene | journal = Molecular and Cellular Biology | volume = 6 | issue = 2 | pages = 511–7 | date = Feb 1986 | pmid = 3023853 | pmc = 367540 | doi = }}
  • {{cite journal | vauthors = Katamine S, Notario V, Rao CD, Miki T, Cheah MS, Tronick SR, Robbins KC | title = Primary structure of the human fgr proto-oncogene product p55c-fgr | journal = Molecular and Cellular Biology | volume = 8 | issue = 1 | pages = 259–66 | date = Jan 1988 | pmid = 3275868 | pmc = 363113 | doi = }}
  • {{cite journal | vauthors = Inoue K, Ikawa S, Semba K, Sukegawa J, Yamamoto T, Toyoshima K | title = Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9 | journal = Oncogene | volume = 1 | issue = 3 | pages = 301–4 | year = 1988 | pmid = 3330776 | doi = }}
  • {{cite journal | vauthors = Nishizawa M, Semba K, Yamamoto T, Toyoshima K | title = Human c-f gr gene does not contain coding sequence for actin-like protein | journal = Japanese Journal of Cancer Research | volume = 76 | issue = 3 | pages = 155–9 | date = Mar 1985 | pmid = 3922831 | doi = }}
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1 : Tyrosine kinases
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