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词条 Fixed drug reaction
释义

  1. Signs and symptoms

  2. Cause

  3. See also

  4. References

  5. External links

{{Infobox medical condition (new)
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}}Fixed drug reactions, also known as fixed drug eruptions, are common and so named because they recur at the same site with each exposure to a particular medication.[1] Medications inducing fixed drug eruptions are usually those taken intermittently.[1]

Signs and symptoms

A painful purple patch of skin that occurs in the same location with repeated exposures to the culprit drug is the classic presentation of a fixed drug reaction. The lips, genitals, and hands are often involved.

Cause

Medications that are commonly implicated as a cause of fixed drug eruptions include the following:

  1. Fluconazole
  2. Ciprofloxacin
  3. Doxycycline
  4. Clarithromycin
  5. NSAIDs (e.g., ibuprofen)
  6. Trimethoprim
  7. Cotrimoxazole
  8. Phenytoin
  9. Cetirizine
  10. Pseudoephedrine&91;2&93;

See also

  • List of cutaneous conditions
  • List of human leukocyte antigen alleles associated with cutaneous conditions
  • Stevens–Johnson syndrome

References

1. ^{{cite book |last1=James |first1=William |last2=Berger |first2=Timothy |last3=Elston |first3=Dirk |year=2005 |title=Andrews' Diseases of the Skin: Clinical Dermatology |edition=10th |publisher=Saunders |isbn=0-7216-2921-0 |page=127}}
2. ^{{cite journal |doi=10.1016/S1081-1206(10)62974-2 |pmid=9564979 |title=Nonpigmenting Fixed Drug Eruption due to Pseudoephedrine |journal=Annals of Allergy, Asthma & Immunology |volume=80 |issue=4 |pages=309–10 |year=1998 |last1=Vidal |first1=Carmen |last2=Pérez-Carral |first2=Celsa |last3=Armisén |first3=Margarita |last4=Prieto |first4=Azucena }}

External links

{{Medical resources
| DiseasesDB =
| ICD10 = L27.1 (ILDS L27.110)
| ICD9 = {{ICD9|692.3}}
| ICDO =
| OMIM =
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| eMedicineSubj =
| eMedicineTopic =
| MeshID =
}}{{Noninfectious inflammatory cutaneous conditions}}{{Cutaneous-condition-stub}}

1 : Drug eruptions

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