“FKBP5”的意思、由来-开放百科全书

Function

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature corticoid receptor hetero-complexes (i.e. progesterone-, glucocorticoid-, mineralocorticoid-receptor complexes) along with the 90 kDa heat shock protein and P23 protein.

Clinical significance

The FKBP5 gene has been found to have multiple polyadenylation sites^[1] and is statistically associated with a higher rate of depressive disorders.^[2]

Interactions

FKBP5 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1.^[3]

Further reading

{{cite journal | vauthors = Schiene-Fischer C, Yu C | title = Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases | journal = FEBS Lett. | volume = 495 | issue = 1–2 | pages = 1–6 | year = 2001 | pmid = 11322937 | doi = 10.1016/S0014-5793(01)02326-2 }}

{{cite journal | vauthors = Baughman G, Wiederrecht GJ, Campbell NF, Martin MM, Bourgeois S | title = FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition | journal = Mol. Cell. Biol. | volume = 15 | issue = 8 | pages = 4395–402 | year = 1995 | pmid = 7542743 | pmc = 230679 | doi = 10.1128/mcb.15.8.4395}}

{{cite journal | vauthors = Smith DF, Baggenstoss BA, Marion TN, Rimerman RA | title = Two FKBP-related proteins are associated with progesterone receptor complexes | journal = J. Biol. Chem. | volume = 268 | issue = 24 | pages = 18365–71 | year = 1993 | pmid = 7688746 | doi = }}

{{cite journal | vauthors = Smith DF, Albers MW, Schreiber SL, Leach KL, Deibel MR | title = FKBP54, a novel FK506-binding protein in avian progesterone receptor complexes and HeLa extracts | journal = J. Biol. Chem. | volume = 268 | issue = 32 | pages = 24270–3 | year = 1993 | pmid = 7693698 | doi = }}

{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}

{{cite journal | vauthors = Johnson J, Corbisier R, Stensgard B, Toft D | title = The involvement of p23, hsp90, and immunophilins in the assembly of progesterone receptor complexes | journal = J. Steroid Biochem. Mol. Biol. | volume = 56 | issue = 1–6 Spec No | pages = 31–7 | year = 1996 | pmid = 8603045 | doi = 10.1016/0960-0760(95)00221-9 }}

{{cite journal | vauthors = Nair SC, Rimerman RA, Toran EJ, Chen S, Prapapanich V, Butts RN, Smith DF | title = Molecular cloning of human FKBP51 and comparisons of immunophilin interactions with Hsp90 and progesterone receptor | journal = Mol. Cell. Biol. | volume = 17 | issue = 2 | pages = 594–603 | year = 1997 | pmid = 9001212 | pmc = 231784 | doi = }}

{{cite journal | vauthors = Baughman G, Wiederrecht GJ, Chang F, Martin MM, Bourgeois S | title = Tissue distribution and abundance of human FKBP51, and FK506-binding protein that can mediate calcineurin inhibition | journal = Biochem. Biophys. Res. Commun. | volume = 232 | issue = 2 | pages = 437–43 | year = 1997 | pmid = 9125197 | doi = 10.1006/bbrc.1997.6307 }}

{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}

{{cite journal | vauthors = Young JC, Obermann WM, Hartl FU | title = Specific binding of tetratricopeptide repeat proteins to the C-terminal 12-kDa domain of hsp90 | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18007–10 | year = 1998 | pmid = 9660753 | doi = 10.1074/jbc.273.29.18007 }}

{{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}

{{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}

{{cite journal | vauthors = Pirkl F, Buchner J | title = Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40 | journal = J. Mol. Biol. | volume = 308 | issue = 4 | pages = 795–806 | year = 2001 | pmid = 11350175 | doi = 10.1006/jmbi.2001.4595 }}

{{cite journal | vauthors = Davies TH, Ning YM, Sánchez ER | title = A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins | journal = J. Biol. Chem. | volume = 277 | issue = 7 | pages = 4597–600 | year = 2002 | pmid = 11751894 | doi = 10.1074/jbc.C100531200 }}

{{cite journal | vauthors = Giraudier S, Chagraoui H, Komura E, Barnache S, Blanchet B, LeCouedic JP, Smith DF, Larbret F, Taksin AL, Moreau-Gachelin F, Casadevall N, Tulliez M, Hulin A, Debili N, Vainchenker W | title = Overexpression of FKBP51 in idiopathic myelofibrosis regulates the growth factor independence of megakaryocyte progenitors | journal = Blood | volume = 100 | issue = 8 | pages = 2932–40 | year = 2002 | pmid = 12351405 | doi = 10.1182/blood-2002-02-0485 }}

{{cite journal | vauthors = Sinars CR, Cheung-Flynn J, Rimerman RA, Scammell JG, Smith DF, Clardy J | title = Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 3 | pages = 868–73 | year = 2003 | pmid = 12538866 | pmc = 298693 | doi = 10.1073/pnas.0231020100 }}

{{cite journal | vauthors = Hubler TR, Denny WB, Valentine DL, Cheung-Flynn J, Smith DF, Scammell JG | title = The FK506-binding immunophilin FKBP51 is transcriptionally regulated by progestin and attenuates progestin responsiveness | journal = Endocrinology | volume = 144 | issue = 6 | pages = 2380–7 | year = 2003 | pmid = 12746298 | doi = 10.1210/en.2003-0092 }}

{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}

1 : EC 5.2.1

Function

Clinical significance

Interactions

See also

References

Further reading