| 词条 | Flocoumafen |
| 释义 |
| Watchedfields = changed | verifiedrevid = 432136847 | ImageFile=Flocoumafen.svg | ImageSize= | IUPACName= 2-Hydroxy-3-[3-[4-([4-(trifluoromethyl)phenyl]methoxy)phenyl]-1,2,3,4-tetrahydronaphthalen-1-yl] chromen-4-one | OtherNames= |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo=90035-08-8 | PubChem=91748 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = C18696 | SMILES = O=C1c2ccccc2O/C(O)=C1/C3c4ccccc4CC(C3)c5ccc(cc5)OCc6ccc(cc6)C(F)(F) |Section2={{Chembox Properties | Formula=C33H25F3O4 | MolarMass=542.54441 | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Flocoumafen is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type. It is a second generation (i.e., high potency) chemical in this class, used commercially as a rodenticide. It has a very high toxicity and is restricted to indoor use and sewers (in the UK). This restriction is mainly due to the increased risk to non-target species, especially due to its tendency to bio-accumulate in exposed organisms. Studies have shown that rodents resistant to first-generation anticoagulants can be adequately controlled with flocoumafen. It was synthesized in 1984 by Shell International Chemical.[1] ToxicityTo most rodents {{LD50}} is 1 mg/kg, but it can vary a lot between species: from 0.12 mg/kg: Microtus arvalis to more than 10 mg/kg Acomys cahirinus. For dogs: 0.075 - 0.25 mg/kg.[1] AntidoteAntidote is vitamin K1. References1. ^1 Flocoumafen -- A new anticoagulant rodenticide See also
8 : Rodenticides|Phenol ethers|Trifluoromethyl compounds|Chromones|Tetralins|Phenols|Vitamin K antagonists|Anticoagulant rodenticides |
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