| 词条 | Flomoxef |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 413515463 | IUPAC_name = (6R,7R)-7-[[2-(Difluoromethylsulfanyl)acetyl]amino]-3-[[1-(2-hydroxyethyl)tetrazol-5-yl]sulfanylmethyl]-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | image = Flomoxef.png | tradename = | Drugs.com = {{drugs.com|international|flomoxef}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 99665-00-6 | CAS_supplemental = | ATC_prefix = J01 | ATC_suffix = DC14 | ATC_supplemental = | PubChem = 65864 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = V9E5U5XF42 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07963 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 15413 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 59274 | chemical_formula = | C=15 | H=18 | F=2 | N=6 | O=7 | S=2 | molecular_weight = 496.46 g/mol | smiles = CO[C@@]1([C@@H]2N(C1=O)C(=C(CO2)CSc3nnnn3CCO)C(=O)O)NC(=O)CSC(F)F | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C15H18F2N6O7S2/c1-29-15(18-8(25)6-31-13(16)17)11(28)23-9(10(26)27)7(4-30-12(15)23)5-32-14-19-20-21-22(14)2-3-24/h12-13,24H,2-6H2,1H3,(H,18,25)(H,26,27)/t12-,15+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = UHRBTBZOWWGKMK-DOMZBBRYSA-N }} Flomoxef is an oxacephem antibiotic. It has been classified as second-generation[1] and fourth-generation.[2] It was patented in 1982 and approved for medical use in 1988.[3] References1. ^{{cite journal |vauthors=Masuda Z, Kurosaki Y, Ishino K, Yamauchi K, Sano S |title=Pharmacokinetic analysis of flomoxef in children undergoing cardiopulmonary bypass and modified ultrafiltration |journal=Gen Thorac Cardiovasc Surg |volume=56 |issue=4 |pages=163–9 |date=April 2008 |pmid=18401677 |doi=10.1007/s11748-007-0208-5 }} {{Cell wall disruptive antibiotics}}{{antibiotic-stub}}2. ^{{cite journal |vauthors=Ito M, Ishigami T |title=The meaning of the development of flomoxef and clinical experience in Japan |journal=Infection |volume=19 Suppl 5 |issue= |pages=S253–7 |year=1991 |pmid=1783441 |doi= 10.1007/bf01645536|url=}} 3. ^{{cite book |last1=Fischer |first1=Jnos |last2=Ganellin |first2=C. Robin |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=496 |url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA496 |language=en}} 9 : Cephalosporin antibiotics|Tetrazoles|Alcohols|Sulfides|Carboxylic acids|Lactams|Ethers|Carboxamides|Organofluorides |
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