| 词条 | Florid cutaneous papillomatosis |
| 释义 |
| name = | synonym = | image = | image_size = | alt = | caption = | pronounce = | specialty = dermatology | symptoms = | complications = | onset = | duration = | types = | causes = | risks = | diagnosis = | differential = | prevention = | treatment = | medication = | prognosis = | frequency = | deaths = }} Florid cutaneous papillomatosis (FCP), also known as Schwartz-Burgess syndrome, is an obligate paraneoplastic syndrome. FCP begins as the sudden onset of numerous cutaneous papillomas that are clinically indistinguishable from viral warts. The papillomas range from 1 to 3 mm in diameter may spread to involve the entire body, including the face. Pruritus, which may sometimes precede the onset of FCP, is evident in the affected regions in about half of patients. Evaluation of a skin biopsy clearly distinguishes FCP from viral warts. FCP is associated with underlying cancer of the breast, bladder, ovary, uterus, prostate, and lung. Other associated underlying malignancies include squamous cell carcinomas and lymphomas such as non-Hodgkin's lymphoma. FCP is sometimes seen together with other signs of internal cancer, especially malignant acanthosis nigricans, tripe palms, Leser–Trélat sign, and hypertrichosis lanuginosa acquisita. FCP tends to improve in association with surgical or chemotherapeutic therapy of the underlying internal cancer. A recurrence or exacerbation of FCP may be linked with tumor regrowth or metastatic spread. Signs and symptomsThe characteristic eruption is of multiple warty papules and nodules beginning on acral skin, especially the hands and wrists, and disseminating onto the skin of the entire body. These skin lesions develop on the trunk, extremities, and face.[1]{{rp|63}} Pruritus is also associated. CausesThe etiology of florid cutaneous papillomatosis is unknown. It is likely directly induced by an underlying neoplasm secreting a growth factor. One candidate may be alpha-transforming growth factor, structurally related to epidermal growth factor, but antigenically distinct from it. The underlying cancer is most often gastric adenocarcinoma[1]{{rp|63}}[2][3] but also with breast cancer, bladder cancer, hepatobiliary cancer, ovarian cancer, uterine cancer,[4] prostate cancer{{Citation needed|date=March 2009}}, lung cancer[5] and cervical cancer.[6] Other associated underlying malignancies include squamous cell carcinomas and lymphomas.[7] PathophysiologyFlorid cutaneous papillomatosis, malignant acanthosis nigricans, and the sign of Leser-Trélat may be highlighted as part of a continuum, with each having a common or similar pathogenic pathway due to an underlying malignancy that produces a factor epidermal growth factor-like activity.{{citation needed|date=June 2017}} DiagnosisThe sudden eruption of papulonodules usually indistinguishable from common viral warts should suggest this diagnosis. These papulonodules begin on the extremities, especially on the dorsa of the hands and the wrists and may disseminate to involve the entire body, including the face.[8] The papulonodules may vary in size from 2–3 mm to 10 mm in diameter. Pruritus is often associated. Florid cutaneous papillomatosis is linked with an underlying cancer. Malignant acanthosis nigricans may also become evident, many times with the sudden eruption of multiple seborrheic keratoses, known as the sign of Leser-Trélat.[9][10][11] Florid cutaneous papillomatosis mandates a search for an underlying malignancy, recognizing that it may be seen in patients with multiple visceral carcinomas. Histologic examination shows uniform and pronounced hyperkeratosis, acanthosis, and papillomatosis without epidermal vacuolization, parakeratosis, or eosinophilic inclusions suggestive of viral warts.[12] The sudden quality of the eruption of florid cutaneous papillomatosis and its anatomic distribution should facilitate distinction from widespread common warts and from epidermodysplasia verruciformis. TreatmentIdentifying and treatment the underlying malignancy constitutes an uptime approach. Topical 5-fluorouracil may occasionally be help, as may oral retinoids, topical steroids, vitamin A acid, urea, salicylic acid, podophyllotoxin, and cryodestruction employing liquid. PrognosisImprovement usually parallels that of the cancer, whether surgical or chemotherapeutic. Generalization of the associated visceral malignancy may worsen the eruption. EpidemiologyFlorid cutaneous papillomatosis is almost twice as common in men than in women, and is usually diagnosed in individuals aged 53–72 years (mean patient age, 58.5 years).[1]{{rp|66}} HistoryFlorid cutaneous papillomatosis was discovered by Robert A. Schwartz and Gordon H. Burgess.[13] The original description was published in the Archives of Dermatology,[14] which is published by American Medical Association. It has since been called the Schwartz-Burgess syndrome.[15][16] Society and culturePatients may have their unaesthetic appearance resulting in isolation from their community, feeling or being unwelcome in public places.[17] References1. ^1 2 {{cite journal |author=Mansouri, P.|title=Florid cutaneous papillomatosis, malignant acanthosis nigrica, palmoplantar keratoderma, and gastric adenocarcinoma |journal=Acta Medical Iranica |volume=37 |issue=1 |year=1999 |url=http://journals.tums.ac.ir/upload_files/pdf/4884.pdf |display-authors=etal}} 2. ^{{cite journal |doi=10.4103/0378-6323.16238 |author=Singhi, M.K.|title=Florid cutaneous papillomatosis with adenocarcinoma of stomach in a 35 year old male |journal=Indian J Dermatol Venereol Leprol |volume=71 |issue=3 |pages=195–6 |year=2005 |url=https://tspace.library.utoronto.ca/bitstream/1807/5515/1/dv05062.pdf |pmid=16394412|display-authors=etal}} 3. ^{{Cite journal | last1 = Klieb | first1 = HB. | last2 = Avon | first2 = SL. | last3 = Gilbert | first3 = J. | last4 = Sade | first4 = S. | last5 = Enepekides | first5 = D. | title = Florid cutaneous and mucosal papillomatosis: mucocutaneous markers of an underlying gastric malignancy. | journal = J Clin Oncol | volume = 31 | issue = 13 | pages = e218–9 |date=May 2013 | doi = 10.1200/JCO.2012.45.2151 | pmid = 23530104 }} 4. ^{{cite journal |author=Yoon Oo Noh, G.C.L. |author2=Mi Kyeong Kim |author3=Youn Soo Kim |author4=Tae Young Yoon |title=A Case of Florid Cutaneous Papillomatosis and Tripe Palm |journal=Korean J Dermatol |volume=7 |issue=40 |year=2002 |url=http://koreamed.org/SearchBasic.php?RID=291794&DT=1&QY=A+%5BALL%5D+Case+%5BALL%5D+Florid+%5BALL%5D+Cutaneous+%5BALL%5D+Papillomatosis+%5BALL%5D+Tripe+%5BALL%5D+Palm+%5BALL%5D}} 5. ^{{cite journal |doi=10.1046/j.1468-3083.2000.00051.x |vauthors=Bottoni U, Dianzani C, Pranteda G, etal |title=Florid cutaneous and mucosal papillomatosis with acanthosis nigricans revealing a primary lung cancer |journal=J Eur Acad Dermatol Venereol |volume=14 |issue=3 |pages=205–8 |date=May 2000 |pmid=11032067 }} 6. ^{{Citation | title = The Combination of Tripe Palms, Acanthosis Nigricans and Florid Cutaneous Papillomatosis in a Patient with Metastatic Cervical Cancer | year = 2004 | journal = Dermatol Sin | pages = 142–147 | volume = 22 | last1 = Tsai | first1 = Yu-Ju | last2 = Tsai | first2 = Yi-Jeng | last3 = Chuan | first3 = Ming-Tuo | last4 = Hu | first4 = Shu-Ling }} 7. ^{{cite journal|last1=Janier|first1=M.|last2=Blanchet-Bardon|first2=C.|last3=Bonvalet|first3=D.|last4=Lenoble|first4=M.|last5=Boiget|first5=F.|last6=Civatte|first6=J.|title=Malignant Acanthosis nigricans Associated with Non-Hodgkin's Lymphoma|journal=Dermatology|volume=176|issue=3|year=1988|pages=133–137|issn=1421-9832|doi=10.1159/000248689}} 8. ^{{cite book|author1=Norman Levine|author2=Carol C. Levine|title=Dermatology Therapy. A - Z Essentials|date=12 February 2004|publisher=Springer|isbn=978-3-540-00864-4|page=242}} 9. ^{{cite book|author1=Mark G. Lebwohl|author2=Warren R. Heymann|author3=John Berth-Jones|author4=Ian Coulson|title=Treatment of Skin Disease: Comprehensive Therapeutic Strategies|date=8 December 2009|publisher=Elsevier Health Sciences|isbn=978-0-7020-4328-4|page=88}} 10. ^{{cite book|author1=Judith Collier|author2=Murray Longmore|author3=Keith Amarakone|title=Oxford Handbook of Clinical Specialties|date=31 January 2013|publisher=Oxford University Press|isbn=978-0-19-959118-3|page=589}} 11. ^{{cite book|author1=Connie Henke Yarbro|author2=Debra Wujcik|author3=Barbara Holmes Gobel|title=Cancer Nursing: Principles and Practice|date=15 November 2010|publisher=Jones & Bartlett Publishers|isbn=978-1-4496-5781-9|page=1902}} 12. ^{{cite book|author1=David Weedon|author2=Geoffrey Strutton|title=Skin pathology|year=1997|publisher=Churchill Livingstone|isbn=978-0-443-05575-1|page=640}} 13. ^{{cite journal|last1=Chou|first1=Che-Yi|last2=Yeh|first2=Shih-Wei|title=Multiple brownish warty papulonodules on left dorsal hand|journal=Dermatologica Sinica|volume=30|issue=2|year=2012|pages=81–82|issn=1027-8117|doi=10.1016/j.dsi.2011.10.004}} 14. ^{{cite journal |doi=10.1001/archderm.114.12.1803 |vauthors=Schwartz RA, Burgess GH |title=Florid cutaneous papillomatosis |journal=Arch Dermatol |volume=114 |issue=12 |pages=1803–6 |date=December 1978 |pmid=153731 |url=http://archderm.ama-assn.org/cgi/pmidlookup?view=long&pmid=153731}} 15. ^{{Cite journal | last1 = Yang | first1 = YH. | last2 = Zhang | first2 = RZ. | last3 = Kang | first3 = DH. | last4 = Zhu | first4 = WY. | title = Three paraneoplastic signs in the same patient with gastric adenocarcinoma. | journal = Dermatol Online J | volume = 19 | issue = 7 | pages = 18966 | year = 2013 | doi = | pmid = 24010512 }} 16. ^{{cite journal|last1=Gao|first1=Xing-Hua|last2=Chen|first2=Hong-Duo|title=Professor Robert A. Schwartz Awarded Title of Honorary Professor, China Medical University, Shenyang, November 20, 2012|journal=International Journal of Dermatology|volume=52|issue=2|year=2013|pages=262|issn=0011-9059|doi=10.1111/ijd.12131_2}} 17. ^{{Cite journal | last1 = Csete | first1 = B. | last2 = Moezzi | first2 = M. | last3 = Lengyel | first3 = Z. | last4 = Hodosi | first4 = B. | last5 = Zombai | first5 = E. | last6 = Battyáni | first6 = Z. | title = Florid cutaneous papillomatosis leading to social exclusion. | journal = Br J Dermatol | volume = 153 | issue = 3 | pages = 667–9 |date=Sep 2005 | doi = 10.1111/j.1365-2133.2005.06772.x | pmid = 16120165 }} Bibliography
External links{{Medical resources| DiseasesDB = 34696 | ICDO = | OMIM = | MedlinePlus = | eMedicineSubj = derm | eMedicineTopic = 917 | MeshID = }}
3 : Rare diseases|Syndromes|Papulosquamous hyperkeratotic cutaneous conditions |
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