| 词条 | Flucindole |
| 释义 |
| verifiedrevid = 444385042 | IUPAC_name = 6,8-difluoro-N,N-dimethyl-2,3,4,9-tetrahydro-1H-carbazol-3-amine | image = Flucindole.svg | tradename = | pregnancy_category = | legal_status = Uncontrolled | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 40594-09-0 | ATC_prefix = none | ATC_suffix = | PubChem = 38531 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 35315 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 5CYU0D0S8M | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D02658 | ChEMBL = 1882682 | C=14 | H=18 | N=2 | molecular_weight = 250.287 g/mol | smiles = CN(C)C1CCC2=C(C1)C3=CC(=CC(=C3N2)F)F | StdInChI = 1S/C14H16F2N2/c1-18(2)9-3-4-13-10(7-9)11-5-8(15)6-12(16)14(11)17-13/h5-6,9,17H,3-4,7H2,1-2H3 | StdInChIKey = FXNCRITWFOVSEP-UHFFFAOYSA-N }}Flucindole is an antipsychotic with a tricyclic structure that was never marketed.[1] It is the 6,8-difluoro derivative of cyclindole.[2] SynthesisSee also
References1. ^{{cite journal | author = Wood PL, McQuade PS | title = Ciclindole and flucindole: novel tetrahydrocarbazolamine neuroleptics | journal = Progress in Neuro-psychopharmacology & Biological Psychiatry | volume = 8 | issue = 4-6 | pages = 773–7 | year = 1984 | pmid = 6152347 | doi = 10.1016/0278-5846(84)90057-5| url = }} {{Antipsychotics}}{{Dopaminergics}}{{Tricyclics}}{{nervous-system-drug-stub}}2. ^{{cite journal |author=Edelson J, Benziger DP |title=Disposition of a series of tetrahydrocarbazoles |journal=Drug Metabolism Reviews |volume=11 |issue=2 |pages=263–89 |year=1980 |pmid=7011760 |doi=10.3109/03602538008994027 |url=}} 3. ^Mooradian, Aram; Dupont, Paul E.; Hlavac, Allan G.; Aceto, Mario D.; Pearl, Jack (1977). "3-Aminotetrahydrocarbazoles as a new series of central nervous system agents". Journal of Medicinal Chemistry 20 (4): 487–492. doi:10.1021/jm00214a005. 4. ^Aram Mooradian {{Cite patent|DE|2240211}} (1973 to Sterling Drug). 5 : Amines|Antipsychotics|Carbazoles|Fluoroarenes|Abandoned drugs |
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