| 释义 |
- References
- Further reading
{{Infobox_gene}}Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.[1][2][3]The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus.[4] References1. ^{{cite journal |vauthors=Kawasaki K, Fearnhead RW | title = On the relationship between tetracycline and the incremental lines in dentine | journal = J Anat | volume = 119 | issue = Pt 1 | pages = 49–59 |date=Sep 1975 | pmid = 1133088 | pmc = 1231614 | doi = }}
2. ^{{cite journal |vauthors=van Heyningen V, Little PF | title = Report of the fourth international workshop on human chromosome 11 mapping 1994 | journal = Cytogenet Cell Genet | volume = 69 | issue = 3-4 | pages = 127–58 |date=May 1995 | pmid = 7698003 | pmc = | doi =10.1159/000133953 }}
3. ^{{cite web | title = Entrez Gene: FOLR2 folate receptor 2 (fetal)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2350| accessdate = }}
4. ^{{cite web | title = Entrez Gene: FOLR2 folate receptor 2 (fetal)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2350| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | author=Henderson GB |title=Folate-binding proteins. |journal=Annu. Rev. Nutr. |volume=10 |issue= |pages= 319–35 |year= 1990 |pmid= 2166548 |doi= 10.1146/annurev.nu.10.070190.001535 }}
- {{cite journal |vauthors=Ragoussis J, Senger G, Trowsdale J, Campbell IG |title=Genomic organization of the human folate receptor genes on chromosome 11q13. |journal=Genomics |volume=14 |issue= 2 |pages= 423–30 |year= 1992 |pmid= 1330883 |doi=10.1016/S0888-7543(05)80236-8 }}
- {{cite journal |vauthors=Freisheim JH, Price EM, Ratnam M |title=Folate coenzyme and antifolate transport proteins in normal and neoplastic cells. |journal=Adv. Enzyme Regul. |volume=29 |issue= |pages= 13–26 |year= 1990 |pmid= 2561247 |doi=10.1016/0065-2571(89)90091-5 }}
- {{cite journal |vauthors=Ratnam M, Marquardt H, Duhring JL, Freisheim JH |title=Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA. |journal=Biochemistry |volume=28 |issue= 20 |pages= 8249–54 |year= 1990 |pmid= 2605182 |doi=10.1021/bi00446a042 }}
- {{cite journal |vauthors=Yan W, Ratnam M |title=Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal. |journal=Biochemistry |volume=34 |issue= 44 |pages= 14594–600 |year= 1995 |pmid= 7578066 |doi=10.1021/bi00044a039 }}
- {{cite journal |vauthors=Sadasivan E, Cedeno MM, Rothenberg SP |title=Characterization of the gene encoding a folate-binding protein expressed in human placenta. Identification of promoter activity in a G-rich SP1 site linked with the tandemly repeated GGAAG motif for the ets encoded GA-binding protein. |journal=J. Biol. Chem. |volume=269 |issue= 7 |pages= 4725–35 |year= 1994 |pmid= 8106441 |doi= }}
- {{cite journal |vauthors=Shen F, Ross JF, Wang X, Ratnam M |title=Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. |journal=Biochemistry |volume=33 |issue= 5 |pages= 1209–15 |year= 1994 |pmid= 8110752 |doi=10.1021/bi00171a021 }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Page ST, Owen WC, Price K, Elwood PC |title=Expression of the human placental folate receptor transcript is regulated in human tissues. Organization and full nucleotide sequence of the gene. |journal=J. Mol. Biol. |volume=229 |issue= 4 |pages= 1175–83 |year= 1993 |pmid= 8445646 |doi= 10.1006/jmbi.1993.1116 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal |vauthors=Wang J, Shen F, Yan W |title=Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion. |journal=Biochemistry |volume=36 |issue= 47 |pages= 14583–92 |year= 1998 |pmid= 9398177 |doi= 10.1021/bi970845w |display-authors=etal}}
- {{cite journal |vauthors=Nakashima-Matsushita N, Homma T, Yu S |title=Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis. |journal=Arthritis Rheum. |volume=42 |issue= 8 |pages= 1609–16 |year= 1999 |pmid= 10446858 |doi= 10.1002/1529-0131(199908)42:8<1609::AID-ANR7>3.0.CO;2-L |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors=Hao H, Qi H, Ratnam M |title=Modulation of the folate receptor type beta gene by coordinate actions of retinoic acid receptors at activator Sp1/ets and repressor AP-1 sites. |journal=Blood |volume=101 |issue= 11 |pages= 4551–60 |year= 2003 |pmid= 12543860 |doi= 10.1182/blood-2002-10-3174 }}
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