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词条 Folylpolyglutamate synthase
释义

  1. Interactive pathway map

  2. References

  3. Further reading

{{Infobox_gene}}Folylpolyglutamate synthase, mitochondrial is an enzyme that in humans is encoded by the FPGS gene.[1]

This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.[1]

Interactive pathway map

{{FluoropyrimidineActivity WP1601|highlight=FPGS}}

References

1. ^1 {{cite web | title = Entrez Gene: FPGS folylpolyglutamate synthase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2356| accessdate = }}

Further reading

{{refbegin | 2}}
  • {{cite journal |vauthors=Garrow TA, Admon A, Shane B |title=Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 19 |pages= 9151–5 |year= 1992 |pmid= 1409616 |doi=10.1073/pnas.89.19.9151 | pmc=50083 }}
  • {{cite journal |vauthors=Cichowicz DJ, Shane B |title=Mammalian folylpoly-gamma-glutamate synthetase. 1. Purification and general properties of the hog liver enzyme. |journal=Biochemistry |volume=26 |issue= 2 |pages= 504–12 |year= 1987 |pmid= 3828320 |doi=10.1021/bi00376a024 }}
  • {{cite journal |vauthors=Jones C, Kao FT, Taylor RT |title=Chromosomal assignment of the gene for folylpolyglutamate synthetase to human chromosome 9. |journal=Cytogenet. Cell Genet. |volume=28 |issue= 3 |pages= 181–94 |year= 1981 |pmid= 6934068 |doi=10.1159/000131529 }}
  • {{cite journal |vauthors=Freemantle SJ, Taylor SM, Krystal G, Moran RG |title=Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene. |journal=J. Biol. Chem. |volume=270 |issue= 16 |pages= 9579–84 |year= 1995 |pmid= 7721888 |doi=10.1074/jbc.270.16.9579 }}
  • {{cite journal |vauthors=Taylor SM, Freemantle SJ, Moran RG |title=Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus. |journal=Cancer Res. |volume=55 |issue= 24 |pages= 6030–4 |year= 1996 |pmid= 8521387 |doi= }}
  • {{cite journal |vauthors=Chen L, Qi H, Korenberg J |title=Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene. |journal=J. Biol. Chem. |volume=271 |issue= 22 |pages= 13077–87 |year= 1996 |pmid= 8662720 |doi=10.1074/jbc.271.22.13077 |display-authors=etal}}
  • {{cite journal |vauthors=Freemantle SJ, Moran RG |title=Transcription of the human folylpoly-gamma-glutamate synthetase gene. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25373–9 |year= 1997 |pmid= 9312158 |doi=10.1074/jbc.272.40.25373 }}
  • {{cite journal |vauthors=McGuire JJ, Russell CA, Balinska M |title=Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines. |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 13012–6 |year= 2000 |pmid= 10777604 |doi=10.1074/jbc.275.17.13012 }}
  • {{cite journal |vauthors=Turner FB, Taylor SM, Moran RG |title=Expression patterns of the multiple transcripts from the folylpolyglutamate synthetase gene in human leukemias and normal differentiated tissues. |journal=J. Biol. Chem. |volume=275 |issue= 46 |pages= 35960–8 |year= 2000 |pmid= 10964921 |doi= 10.1074/jbc.M005228200 }}
  • {{cite journal |vauthors=Leclerc GJ, Barredo JC |title=Folylpoly-gamma-glutamate synthetase gene mRNA splice variants and protein expression in primary human leukemia cells, cell lines, and normal human tissues. |journal=Clin. Cancer Res. |volume=7 |issue= 4 |pages= 942–51 |year= 2001 |pmid= 11309345 |doi= }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
  • {{cite journal |vauthors=Wang Y, Zhao R, Goldman ID |title=Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line. |journal=Biochem. Pharmacol. |volume=65 |issue= 7 |pages= 1163–70 |year= 2003 |pmid= 12663051 |doi=10.1016/S0006-2952(03)00007-8 }}
  • {{cite journal |vauthors=Odin E, Wettergren Y, Nilsson S |title=Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. |journal=Clin. Cancer Res. |volume=9 |issue= 16 Pt 1 |pages= 6012–9 |year= 2004 |pmid= 14676127 |doi= |display-authors=etal}}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
  • {{cite journal |vauthors=Wettergren Y, Odin E, Nilsson S |title=Low expression of reduced folate carrier-1 and folylpolyglutamate synthase correlates with lack of a deleted in colorectal carcinoma mRNA splice variant in normal-appearing mucosa of colorectal carcinoma patients. |journal=Cancer Detect. Prev. |volume=29 |issue= 4 |pages= 348–55 |year= 2006 |pmid= 16122883 |doi= 10.1016/j.cdp.2005.06.006 |display-authors=etal}}
  • {{cite journal |vauthors=Nair JR, McGuire JJ |title=Submitochondrial localization of the mitochondrial isoform of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells. |journal=Biochim. Biophys. Acta |volume=1746 |issue= 1 |pages= 38–44 |year= 2005 |pmid= 16169100 |doi= 10.1016/j.bbamcr.2005.08.004 }}
  • {{cite journal |vauthors=Leclerc GJ, Leclerc GM, Kinser TT, Barredo JC |title=Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells. |journal=BMC Cancer |volume=6|pages= 132 |year= 2006 |pmid= 16707018 |doi= 10.1186/1471-2407-6-132 | pmc=1513244 }}
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