请输入您要查询的百科知识:

 

词条 Francis Collins
释义

  1. Early years

  2. Genetics research

  3. Genomics

  4. NIH director

     Nomination and confirmation  Projects 

  5. Music

  6. Awards and honors

  7. Views

     Christianity  Agnosticism  Abortion 

  8. Books

  9. See also

  10. References

  11. Further reading

  12. External links

{{other people}}{{Use mdy dates|date=January 2017}}{{Infobox officeholder
| name = Francis Collins
| image = Francis Collins official photo.jpg
| order = 16th
| title = Director of the National Institutes of Health
| president = Barack Obama
Donald Trump
| term_start = August 7, 2009
| term_end =
| predecessor = Elias Zerhouni
| successor =
| order2 = 2nd
| title2 = Director of the National Human Genome Research Institute
| president2 = George H.W. Bush
Bill Clinton
George W. Bush
| term_start2 = 1993
| term_end2 = August 1, 2008
| predecessor2 = Michael M. Gottesman {{small|(Acting)}}
James D. Watson
| successor2 = Alan E. Guttmacher {{small|(Acting)}}
Eric D. Green
| birth_name = Francis Sellers Collins
| birth_date = {{birth date and age|1950|04|14}}
| birth_place = Staunton, Virginia, U.S.
| death_date =
| death_place =
| party =
| spouse = Diane Baker
| education = University of Virginia {{small|(BS)}}
Yale University {{small|(PhD)}}
University of North Carolina,
Chapel Hill {{small|(MD)}}
| website = {{URL|https://www.nih.gov/about-nih/who-we-are/nih-director|Office of the Director}}
| module =
| fields = Molecular genetics
| workplaces = {{ublist|University of Michigan|National Human Genome Research Institute|National Institutes of Health}}
| thesis_title = Semiclassical theory of vibrationally inelastic scattering, with application to H+ + H₂
| thesis_url = https://search.proquest.com/docview/288233821/
| thesis_year = 1974
| doctoral_advisor = R. James Cross, Jr.
| academic_advisors =
| doctoral_students =
| notable_students =
| known_for = Chromosome jumping
| influences =
| influenced =
| awards =
}}

Francis Sellers Collins (born April 14, 1950) is an American physician-geneticist who discovered the genes associated with a number of diseases and led the Human Genome Project. He is director of the National Institutes of Health (NIH) in Bethesda, Maryland, United States.

Before being appointed director of the NIH, Collins led the Human Genome Project and other genomics research initiatives as director of the National Human Genome Research Institute (NHGRI), one of the 27 institutes and centers at NIH. Before joining NHGRI, he earned a reputation as a gene hunter at the University of Michigan.[1] He has been elected to the Institute of Medicine and the National Academy of Sciences, and has received the Presidential Medal of Freedom and the National Medal of Science.

Collins also has written a number of books on science, medicine, and religion, including the New York Times bestseller, A Scientist Presents Evidence for Belief. After leaving the directorship of NHGRI and before becoming director of the NIH, he founded and served as president of The BioLogos Foundation, which promotes discourse on the relationship between science and religion and advocates the perspective that belief in Christianity can be reconciled with acceptance of evolution and science, especially through the advancement of evolutionary creation.[2] In 2009, Pope Benedict XVI appointed Collins to the Pontifical Academy of Sciences.[3]

Early years

Collins was born in Staunton, Virginia, the youngest of four sons of Fletcher Collins and Margaret James Collins. Raised on a small farm in Virginia's Shenandoah Valley, Collins was home schooled until the sixth grade.[4] He attended Robert E. Lee High School in Staunton, Virginia. Through most of his high school and college years he aspired to be a chemist, and he had little interest in what he then considered the "messy" field of biology. What he referred to as his "formative education" was received at the University of Virginia, where he earned a Bachelor of Science degree in Chemistry in 1970. He went on to graduate as a Doctor of Philosophy in physical chemistry at Yale University in 1974.[5] While at Yale, a course in biochemistry sparked his interest in the subject. After consulting with his mentor from the University of Virginia, Carl Trindle, he changed fields and enrolled in medical school at the University of North Carolina at Chapel Hill, earning a Doctor of Medicine degree there in 1977.

From 1978 to 1981, Collins served a residency and chief residency in internal medicine at North Carolina Memorial Hospital in Chapel Hill. He then returned to Yale, where he was a Fellow in Human Genetics at the medical school from 1981 to 1984.

Genetics research

At Yale, Collins worked under the direction of Sherman Weissman, and in 1984 the two published a paper, "Directional Cloning of DNA Fragments at a Large distance From an Initial Probe: a Circularization Method".[6] The method described was named chromosome jumping, to emphasize the contrast with an older and much more time-consuming method of copying DNA fragments called chromosome walking.[7]

Collins joined the University of Michigan faculty in 1984, rising to the rank of professor in internal medicine and human genetics. His gene-hunting approach, which he named "positional cloning",[8][9] developed into a powerful[10] component of modern molecular genetics.

Several scientific teams worked in the 1970s and 1980s to identify genes and their loci as a cause of cystic fibrosis. Progress was modest until 1985, when Lap-Chee Tsui and colleagues at Toronto's Hospital for Sick Children identified the locus for the gene.[11] It was then determined that a shortcut was needed to speed the process of identification, so Tsui contacted Collins, who agreed to collaborate with the Toronto team and share his chromosome-jumping technique. The gene was identified in June 1989,[12][13] and the results were published in the journal Science on September 8, 1989.[14] This identification was followed by other genetic discoveries made by Collins and a variety of collaborators. They included isolation of the genes for Huntington's disease,[15] neurofibromatosis,[16][17] multiple endocrine neoplasia type 1,[18] inv(16) AML[19] and Hutchinson–Gilford progeria syndrome.[20]

Genomics

In 1993 National Institutes of Health Director Bernadine Healy appointed Collins to succeed James D. Watson as director of the National Center for Human Genome Research, which became National Human Genome Research Institute (NHGRI) in 1997. As director, he oversaw the International Human Genome Sequencing Consortium,[21] which was the group that successfully carried out the Human Genome Project.

In 1994 Collins founded NHGRI's Division of Intramural Research,[22] a collection of investigator-directed laboratories that conduct genome research on the NIH campus.

In June 2000 Collins was joined by President Bill Clinton and biologist Craig Venter in making the announcement of a working draft of the human genome.[23] He stated that "It is humbling for me, and awe-inspiring to realize that we have caught the first glimpse of our own instruction book, previously known only to God."[24][25][26] An initial analysis was published in February 2001, and scientists worked toward finishing the reference version of the human genome sequence by 2003, coinciding with the 50th anniversary of James D. Watson and Francis Crick's publication of the structure of DNA.

Another major activity at NHGRI during his tenure as director was the creation of the haplotype map of the human genome. This International HapMap Project produced a catalog of human genetic variations—called single-nucleotide polymorphisms—which is now being used to discover variants correlated with disease risk. Among the labs engaged in that effort is Collins' own lab at NHGRI, which has sought to identify and understand the genetic variations that influence the risk of developing type 2 diabetes.

In addition to his basic genetic research and scientific leadership, Collins is known for his close attention to ethical and legal issues in genetics. He has been a strong advocate for protecting the privacy of genetic information and has served as a national leader in securing the passage of the federal Genetic Information and Nondiscrimination Act, which prohibits gene-based discrimination in employment and health insurance.[27] In 2013, spurred by concerns over the publication of the genome of the widely used HeLa cell line derived from the late Henrietta Lacks, Collins and other NIH leaders worked with the Lacks family to reach an agreement to protect their privacy, while giving researchers controlled access to the genomic data.[28]

Building on his own experiences as a physician volunteer in a rural missionary hospital in Nigeria,[29] Collins is also very interested in opening avenues for genome research to benefit the health of people living in developing nations. For example, in 2010, he helped establish an initiative called Human Heredity and Health in Africa (H3Africa)[30] to advance African capacity and expertise in genomic science.

Collins announced his resignation from NHGRI on May 28, 2008, but has continued to maintain an active lab there.[31]

NIH director

Nomination and confirmation

On July 8, 2009, President Barack Obama nominated Collins as Director of the National Institutes of Health,[32] and the Senate unanimously confirmed him for the post. He was sworn in by Health and Human Services Secretary Kathleen Sebelius on August 7, 2009.[33]

Science writer Jocelyn Kaiser opined that Collins was "known as a skilled administrator and excellent communicator," that Obama's nomination "did not come as a big surprise" and that the appointment "ignited a volley of flattering remarks from researchers and biomedical groups." Yet, she wrote, Collins "does have his critics," some of them who were concerned with the new director's "outspoken Christian faith."[34]Washington Post staffer David Brown wrote, however, that Collins' status as a "born-again Christian . . . may help him build bridges with those who view some gene-based research as a potential threat to religious values."[35] Collins' appointment was welcomed by the chief executive officer of the American Association for the Advancement of Science[35] and by Bernadine Healy, the former head of the National Institutes of Health.[36]

In October 2009, shortly after his nomination as NIH director, Collins stated in an interview in The New York Times: "I have made it clear that I have no religious agenda for the N.I.H., and I think the vast majority of scientists have been reassured by that and have moved on."[37]

On October 1, 2009, in the second of his four appearances on The Colbert Report, Collins discussed his leadership at the NIH and other topics such as personalized medicine and stem cell research. And, in November 2011, Collins was included on The New Republic's list of Washington's most powerful, least famous people. Collins appeared on the series finale of The Colbert Report, participating in a chorus with several other famous people singing "We'll Meet Again".[38][39]

On June 6, 2017, President Donald Trump announced his selection of Collins to continue to serve as the NIH Director.

Projects

Collins was instrumental in establishing the National Center for Advancing Translational Sciences (NCATS) on December 23, 2011.[40] Other projects included increased support for Alzheimer's disease research, which was announced by Secretary Sebelius and Collins in May 2012;[41] the Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative, announced by President Obama and Collins on April 2, 2013, at the White House, and, in February 2014, the Accelerating Medicines Partnership (AMP), a public-private partnership between NIH, the U.S. Food and Drug Administration, 10 biopharmaceutical firms, and multiple non-profit organizations.

In January 2015 President Obama announced the NIH-led Precision Medicine Initiative (PMI) in his State of the Union address.[42] Through advances in research, technology, and policies that empower patients, PMI will enable a new era of precision medicine long envisioned by Collins and many others in which researchers, providers, and patients work together to develop more individualized care. In fiscal year 2016, the first funding for the initiative was awarded, with $130 million allocated to NIH to build a national, large-scale research participant group, called a cohort, and $70 million allocated to NIH's National Cancer Institute as part of PMI for Oncology. The PMI Cohort Program will seek to extend precision medicine to all diseases by building a national research cohort of 1 million or more U.S. participants.[43] In January 2016, in his State of the Union address, President Obama called for a new initiative, to be led by Vice President Joe Biden, to galvanize the nation's research efforts against cancer.[44] Fueled by an additional $680 million in the proposed fiscal year 2017 budget for NIH, the National Cancer Moonshot Initiative will aim to accelerate progress toward the next generation of interventions to reduce cancer incidence and improve patient outcomes.[45]

In other precedent-setting actions during his time as NIH Director, Collins in June 2013 outlined plans to substantially reduce the use of chimpanzees in NIH-funded biomedical research.[46] In November 2015, he announced NIH will no longer support any biomedical research involving chimpanzees.[47] In January 2013, Collins also created two senior scientific positions as part of the NIH's response to an advisory group's recommendations on Big Data and the diversity of the scientific workforce.[48] In December 2013, Collins announced the selection of Philip E. Bourne as NIH's first Associate Director for Data Science,[49] and, in response to internal NIH working group recommendations, Collins appointed Stanford cardiologist Hannah Valantine in 2014 as the institution's first Chief Officer for Scientific Workforce Diversity.[50] In December 2015 Collins and other NIH leaders released a detailed plan that charted a course for NIH's efforts over the ensuing five years The NIH-Wide Strategic Plan, Fiscal Years 2016-2020: Turning Discovery Into Health[51] was aimed at ensuring the agency remains well positioned to capitalize on new opportunities for scientific exploration and to address new challenges for human health.

Music

Mention of Collins' love of guitar playing and motorcycle riding can often be found in articles about him.[52]

While directing NHGRI, he formed a rock band with other NIH scientists. Sometimes the band, called "The Directors," dueled with a rock band from Johns Hopkins University, led by cancer researcher Bert Vogelstein. Lyrics of The Directors' songs included spoofs of rock and gospel classics re-written to address the challenges of contemporary biomedical research.[53] Collins has performed at TEDMED 2012, StandUpToCancer,[54] The 2017 Southern Methodist University Commencement[55] and Rock Stars of Science.[56]

Awards and honors

While leading the National Human Genome Research Institute, Collins was elected to the Institute of Medicine and the National Academy of Sciences. He was a Kilby International Awards recipient in 1993.[57] He received the Biotechnology Heritage Award with J. Craig Venter in 2001, from the Biotechnology Industry Organization (BIO) and the Chemical Heritage Foundation.[58][59] He received the William Allan Award from the American Society of Human Genetics in 2005. In 2007 he was presented with the Presidential Medal of Freedom.[60] In 2008 he was awarded the Inamori Ethics Prize[61] and National Medal of Science.[62] In the same year, Collins won the Trotter Prize where he delivered a lecture called "The Language of God".

Collins and Venter shared the "Biography of the Year" title from A&E Network in 2000.[63] In 2005, Collins and Venter were honored as two of "America's Best Leaders" by U.S. News & World Report and the Harvard University Center for Public Leadership.[64]

Collins received the Albany Medical Center Prize in 2010 and the Pro Bono Humanum Award of the Galien Foundation in 2012.[65]

Collins was a keynote speaker at the Congress of Future Medical Leaders in 2014.

Views

Christianity

By graduate school Collins considered himself an atheist. However, a conversation with a hospital patient led him to question his lack of religious views, and he investigated various faiths. He familiarized himself with the evidence for and against God in cosmology, and on the recommendation of a Methodist minister used Mere Christianity by C. S. Lewis as a foundation to develop his religious views. He eventually came to a conclusion and became a Christian after a "leap of faith" when he saw a frozen waterfall during a hike on a fall afternoon.[66] He has described himself as a "serious Christian".[27]

In his 2006 book A Scientist Presents Evidence for Belief, Collins wrote that scientific discoveries were an "opportunity to worship" and that he rejected both Young Earth creationism and intelligent design. His own belief, he wrote, was theistic evolution or evolutionary creation, which he preferred to call BioLogos. He wrote that one can "think of DNA as an instructional script, a software program, sitting in the nucleus of the cell".[67] He appeared in December 2006 on The Colbert Report television show

and in a March 2007 Fresh Air radio interview to discuss this book.[68][69] In an interview with D. J. Grothe on the Point of Inquiry podcast he said that the overall aim of the book was to show that "one can be intellectually in a rigorous position and argue that science and faith can be compatible", and that he was prompted to write the book because "most people are seeking a possible harmony between these worldviews [science and faith], and it seems rather sad that we hear so little about this possibility.[70]

Collins is a critic of intelligent design, and for this reason he was not asked to participate in the 2008 documentary No Intelligence Allowed. Walt Ruloff, a producer for the film, claimed that by rejecting intelligent design, Collins was "toeing the party line", a claim which Collins called "just ludicrous".[71] In an interview he stated that "intelligent design is headed for collapse in the not too distant future" and that "science class ought to be about science, and opening the door to religious perspectives in that setting is a big mistake."[70] In 2007, Collins founded the BioLogos Foundation to "contribute to the public voice that represents the harmony of science and faith". He served as the foundation's president until he was confirmed as director of the NIH.[72] Collins has also spoken at the Veritas Forum on the relationship between science and religion and the existence of God.[73]

Christopher Hitchens referred to Francis Collins as a 'Great American' and stated that Collins was one of the most devout believers he had ever met.[74] He further stated that Collins was sequencing the genome of the cancer that would ultimately claim Hitchens's life, and that their friendship despite their differing opinion on religion was an example of the greatest armed truce in modern times.

Agnosticism

In an interview with National Geographic in February 2007, writer John Horgan criticized Collins' description of agnosticism as "a cop-out". In response, Collins clarified his position on agnosticism so as to exclude

earnest agnostics who have considered the evidence and still don't find an answer. I was reacting to the agnosticism I see in the scientific community, which has not been arrived at by a careful examination of the evidence. I went through a phase when I was a casual agnostic, and I am perhaps too quick to assume that others have no more depth than I did.[75]

Abortion

In a 1998 interview with Scientific American, Collins stated that he is "intensely uncomfortable with abortion as a solution to anything" and does not "perceive a precise moment at which life begins other than the moment of conception". However, in the same interview it was said that Collins also "does not advocate changing the law".[76]

Books

  • Principles of Medical Genetics, 2nd Edition, with T.D. Gelehrter and D. Ginsburg (Williams & Wilkins, 1998)
  • A Scientist Presents Evidence for Belief (Free Press, 2006)
  • The Language of Life: DNA and the Revolution in Personalized Medicine (HarperCollins, published in early 2010)
  • Belief: Readings on the Reason for Faith (HarperOne, March 2, 2010)
  • The Language of Science and Faith: Straight Answers to Genuine Questions with Karl Giberson IVP Books (February 15, 2011)

See also

  • List of events in National Human Genome Research Institute history
  • Science and religion

References

1. ^{{Cite news|url=http://articles.chicagotribune.com/1990-09-21/news/9003190188_1_cystic-fibrosis-healthy-genes|title=Gene Therapy Cures Cystic Fibrosis In Lab|work=tribunedigital-chicagotribune|access-date=2018-01-05|language=en}}
2. ^{{cite web |url=http://biologos.org/about |title=About The BioLogos Foundation |publisher=The Biologos Foundation |accessdate=May 3, 2014 |quote=We embrace the historical Christian faith, upholding the authority and inspiration of the Bible. We affirm evolutionary creation, recognizing God as Creator of all life over billions of years. We seek truth, ever learning as we study the natural world and the Bible.}}
3. ^{{Cite news|url=https://www.catholicnewsagency.com/news/human_genome_and_embryology_experts_named_to_pontifical_academy_of_sciences|title=Human genome and embryology experts named to Pontifical Academy of Sciences|work=Catholic News Agency|access-date=2018-01-05|language=en}}
4. ^Google Book Search A Scientist Presents Evidence for Belief, [https://books.google.com/books?id=JcMCmBnpHGsC&dq=%22language+of+god%22+collins+homeschool&pg=PP1&ots=qQM1QRH3B5&source=bn&sig=mdeuF90uw_WdkUokgoXgrtMYBX8&hl=en&sa=X&oi=book_result&resnum=4&ct=result#PPA13,M1 Chapter 1]
5. ^{{cite thesis |url=https://search.proquest.com/docview/288233821/ |title=Semiclassical theory of vibrationally inelastic-scattering, with application to proton + hydrogen molecule. |date=1974 |publisher=Yale University |type=Ph.D. |last=Collins |first=Francis Sellers |via=ProQuest |subscription=yes |oclc=702791906}}
6. ^{{cite web |author1=Francis S. Collins |author2=Sherman M. Weissman |title=Directional cloning of DNA fragments at a large distance from an initial probe: a circularization method |publisher=Proc. Natl. Acad. Sci. USA |date=Nov 1984 |url=http://www.pnas.org/content/81/21/6812.full.pdf+html?sid=4509210e-8129-4da3-b99c-dd5829a5a9c2 |accessdate=September 29, 2011}}
7. ^{{cite journal |author=Leon. E. Rosenberg |title=Introductory Speech for Francis S. Collins |year=2006 |pmc=1559551 |pmid=16909377 |doi=10.1086/500276 |volume=79 |issue=3 |journal=Am J Hum Genet |pages=419–20}}
8. ^{{cite web |url=https://rowan.biology.ualberta.ca/courses/genet302/uploads/winter11/gane/private/genet302-GW-week3_noQ.pdf |title=Positional cloning of human disease genes: a reversal of scientific priorities |publisher=University of Alberta, Department of Biological Science |accessdate=October 16, 2011 |archive-url=https://web.archive.org/web/20120425021226/https://rowan.biology.ualberta.ca/courses/genet302/uploads/winter11/gane/private/genet302-GW-week3_noQ.pdf |archive-date=April 25, 2012 |dead-url=yes |df=mdy-all }}
9. ^{{cite journal |author=Collins F |year=1992 |title=Positional Cloning: Let's not call it reverse anymore |url= |journal=Nature Genetics |volume=1 |issue=1 |pages=3–6 |doi=10.1038/ng0492-3 |pmid=1301996}}
10. ^{{Cite journal |url=http://www.sciencedirect.com/science/article/pii/0959437X95800425 |title=Positional cloning reaches maturity |last=Nelson |first=David L. |date=Jun 1995 |journal=Curr Opin Genet Dev |accessdate=August 25, 2014 |doi=10.1016/0959-437X(95)80042-5 |pmid=7549422 |volume=5 |issue=3 |pages=298–303}}
11. ^{{cite journal |last=Tsui |first=LC |author2=Buchwald M |author3=Barker D |title=Cystic fibrosis locus defined by a genetically linked polymorphic DNA marker |journal=Science |date=November 29, 1985 |volume=230 |issue=4729 |pages=1054–1057 |doi=10.1126/science.2997931 |bibcode = 1985Sci...230.1054T |citeseerx=10.1.1.390.9197 }}
12. ^{{cite web |url=http://www.hhmi.org/genetictrail/a120.html |title=Blazing a Genetic Trail/.../Jumping Toward the Gene |author=Pines, Maya |publisher=Howard Hughes Medical Institute |year=2008 |accessdate=October 16, 2011}}
13. ^{{cite web |url=http://www.hhmi.org/genetictrail/a130.html |title=Stalking a Lethal Gene:Discovering the Gene for Cystic Fibrosis |author=Pines, Maya |publisher=Howard Hughes Medical Institute |year=2008 |accessdate=October 16, 2011}}
14. ^{{cite journal |last1=Marx |first1=J. |year=1989 |title=The cystic fibrosis gene is found |journal=Science |volume=245 |issue=4921 |pages=923–5 |bibcode=1989Sci...245..923M |doi=10.1126/science.2772644 |pmid=2772644}}
15. ^{{cite journal |last1=MacDonald |first1=M |year=1993 |title=A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes |journal=Cell |volume=72 |issue=6 |pages=971–83 |doi=10.1016/0092-8674(93)90585-E |pmid=8458085}}
16. ^{{cite book |title=Rubin's Pathology: Clinicopathologic Foundation of Medicine |first1=Raphael |last1=Rubin |first2=David S. |last2=Strayer |publisher=Wolters Kluwer Health: Lippincott Williams & Wilkins |edition=5th |date=2008 |location=Baltimore |pages=201–3 |isbn=978-0-7817-9516-6}}
17. ^{{cite book |author=Fauci|title=Harrison's Principles of Internal Medicine (Small textbook) |edition=16th |pages=2453|display-authors=etal}}
18. ^{{cite journal |last1=Chandrasekharappa |first1=S. C. |last2=Guru |first2=S. C. |last3=Manickam |first3=P |last4=Olufemi |first4=S. E. |last5=Collins |first5=F. S. |last6=Emmert-Buck |first6=M. R. |last7=Debelenko |first7=L. V. |last8=Zhuang |first8=Z |last9=Lubensky |first9=I. A. |last10=Liotta |first10=L. A. |last11=Crabtree |first11=J. S. |last12=Wang |first12=Y |last13=Roe |first13=B. A. |last14=Weisemann |first14=J |last15=Boguski |first15=M. S. |last16=Agarwal |first16=S. K. |last17=Kester |first17=M. B. |last18=Kim |first18=Y. S. |last19=Heppner |first19=C |last20=Dong |first20=Q |last21=Spiegel |first21=A. M. |last22=Burns |first22=A. L. |last23=Marx |first23=S. J. |year=1997 |title=Positional Cloning of the Gene for Multiple Endocrine Neoplasia-Type 1 |journal=Science |volume=276 |issue=5311 |pages=404–7 |doi=10.1126/science.276.5311.404 |pmid=9103196}}
19. ^Science 261 (5124): 1041–4
20. ^{{cite journal |last1=Eriksson |first1=Maria |last2=Brown |first2=W. Ted |last3=Gordon |first3=Leslie B. |last4=Glynn |first4=Michael W. |last5=Singer |first5=Joel |last6=Scott |first6=Laura |last7=Erdos |first7=Michael R. |last8=Robbins |first8=Christiane M. |last9=Moses |first9=Tracy Y. |last10=Berglund |first10=Peter |last11=Dutra |first11=Amalia |last12=Pak |first12=Evgenia |last13=Durkin |first13=Sandra |last14=Csoka |first14=Antonei B. |last15=Boehnke |first15=Michael |last16=Glover |first16=Thomas W. |last17=Collins |first17=Francis S. |year=2003 |title=Recurrent de novo point mutations in lamin a cause Hutchinson–Gilford progeria syndrome |journal=Nature |volume=423 |issue=6937 |pages=293–8 |bibcode=2003Natur.423..293E |doi=10.1038/nature01629 |pmid=12714972}}
21. ^{{cite web|url=http://www.genome.gov/11006939|title=IHG Sequencing Centers|author=|date=|website=National Human Genome Research Institute (NHGRI)|accessdate=March 29, 2018}}
22. ^{{cite web |url=http://www.genome.gov/10001036 |title=The Division of Intramural Research |editor=National Human Genome Research Institute |accessdate=October 16, 2011}}
23. ^Jamie Shreeve, "[https://www.usnews.com/usnews/news/articles/051031/31genome.htm The Blueprint of Life] {{webarchive |url=https://web.archive.org/web/20071130184339/http://www.usnews.com/usnews/news/articles/051031/31genome.htm |date=November 30, 2007 }}," U.S. News and World Report, 10/31/05, URL accessed January 30, 2007.
24. ^{{cite web |url=http://articles.latimes.com/2006/aug/17/nation/na-collins17/3 |title=Faithful to God, Science |last=Simon |first=Stephanie |publisher=Los Angeles Times |accessdate=May 3, 2014 |quote="It is humbling for me, and awe-inspiring," he said, standing at Clinton's side, "to realize that we have caught the first glimpse of our own instruction book, previously known only to God." That moment moved Collins -- who is married and has two grown daughters — to talk more publicly about his faith and to write the book. "It's been a bit like taking a public bath," he said.}}
25. ^{{cite book |last=Lennox |first=John C. |title=God's Undertaker: Has Science Buried God? |year=2009 |publisher=Lion Books |isbn=9780745953717 |page=176 |quote=At the public announcement of the completion of the Human Genome Project, its director, Francis Collins, said: 'It is humbling for me and awe-inspiring to realize that we have caught the first glimpse of our own instruction book, previously known only to God.'}}
26. ^{{cite web |url=http://transcripts.cnn.com/TRANSCRIPTS/0006/26/bn.01.html |title=President Clinton, British Prime Minister Tony Blair Deliver Remarks on Human Genome Milestone |date=June 26, 2000 |publisher=CNN |accessdate=May 3, 2014}}
27. ^{{cite web |url=https://www.pbs.org/wnet/religionandethics/transcripts/collins.html |title=Transcript, Bob Abernethy's interview with Dr. Francis Collins, director of the Human Genome Project at the National Institutes of Health. |publisher=PBS, Religion and Ethics Newsweekly |accessdate=October 16, 2011}}
28. ^{{cite web|url=http://www.nih.gov/about/director/statement-hela-08072013.htm|title=The HeLa Genome: An Agreement on Privacy and Access|author=|date=June 13, 2016|website=nih.gov|accessdate=March 29, 2018}}
29. ^{{cite web |url=https://www.nytimes.com/1993/11/30/science/scientist-at-work-francis-s-collins-unlocking-the-secrets-of-the-genome.html?pagewanted=all&src=pm |title=Scientist at work: Francis S. Collins; unlocking the secrets of the Genome |publisher=The New York Times |date=Nov 1993}}
30. ^National Institutes of Health, "NIH and Wellcome Trust Announce Partnership to Support Population-Based Genome Studies in Africa," NIH News, June 22, 2010
31. ^Chemical & Engineering News, Vol. 86 No. 31, August 4, 2008, p. 33, "Francis Collins leaves NIH"
32. ^{{cite web|url=http://www.whitehouse.gov/the_press_office/President-Obama-Announces-Intent-to-Nominate-Francis-Collins-as-NIH-Director/|title="President Obama Announces Intent to Nominate Francis Collins as NIH Director," Press Office, the White House, July 8, 2009|author=|date=|website=whitehouse.gov|accessdate=March 29, 2018|archive-url=https://www.webcitation.org/6AqE0mUL4?url=http://www.whitehouse.gov/the_press_office/President-Obama-Announces-Intent-to-Nominate-Francis-Collins-as-NIH-Director/|archive-date=September 21, 2012|dead-url=yes|df=mdy-all}}
33. ^[https://www.hhs.gov/news/press/2009pres/08/20090807d.html Secretary Sebelius Announces Senate Confirmation of Dr. Francis Collins as Director of the National Institutes of Health] {{Webarchive|url=https://www.webcitation.org/6AqE1Sgbj?url=http://www.hhs.gov/news/press/2009pres/08/20090807d.html |date=September 21, 2012 }} 7-Aug-09
34. ^{{cite journal |last1=Kaiser |first1=J. |year=2009 |title=White House Taps Former Genome Chief Francis Collins as NIH Director |journal=Science |volume=325 |issue=5938 |pages=250–1 |pmid=19608881 |doi=10.1126/science.325_250a}}
35. ^{{cite web |url=https://www.washingtonpost.com/wp-dyn/content/article/2009/07/08/AR2009070802769.html |title=Obama picks Francis Collins as new NIH Director |publisher=Washington Post |date=July 8, 2009 |accessdate=October 16, 2011}}
36. ^Francis Collins Leader for the 21st Century NIH US News & World Report 9-June-09
37. ^{{cite news |url=https://www.nytimes.com/2009/10/06/health/06nih.html |work=The New York Times |title=For N.I.H. Chief, Issues of Identity and Culture |first=Gardiner |last=Harris |date=October 6, 2009 |accessdate=May 2, 2010}}
38. ^{{cite news |last=The Editors |title=Washington's Most Powerful, Least Famous People |url=http://www.tnr.com/article/politics/96131/washingtons-most-powerful-least-famous-people?passthru=ZTM3Y2VhYmZjNmIzMjllNzQ3MjMxOGEzMmJlZjg1NzI |work=The New Republic |date=November 3, 2011 |accessdate=October 25, 2011}}
39. ^{{cite web |url=http://www.colbertnation.com/the-colbert-report-videos/250628/october-01-2009/francis-collins |title=Francis Collins |date=October 1, 2009 |accessdate=October 18, 2009 |publisher=The Colbert Report}}
40. ^{{cite web|url=http://www.nih.gov/news/health/dec2011/od-23.htm|title=NIH establishes National Center for Advancing Translational Sciences|author=|date=September 18, 2015|website=nih.gov|accessdate=March 29, 2018}}
41. ^{{Cite web |url=http://nihrecord.od.nih.gov/newsletters/2012/06_22_2012/story1.htm |title="Researchers, Advocates Gather to Accelerate Alzheimer's Research," NIH Record, June 22, 2012 |access-date=August 30, 2013 |archive-url=https://web.archive.org/web/20130326154314/http://nihrecord.od.nih.gov/newsletters/2012/06_22_2012/story1.htm |archive-date=March 26, 2013 |dead-url=yes |df=mdy-all }}
42. ^{{Cite web|url=https://www.whitehouse.gov/the-press-office/2015/01/30/fact-sheet-president-obama-s-precision-medicine-initiative|title=FACT SHEET: President Obama's Precision Medicine Initiative|date=January 30, 2015|website=whitehouse.gov|access-date=April 29, 2016}}
43. ^{{Cite web|url=https://www.nih.gov/news-events/news-releases/nih-framework-points-way-forward-building-national-large-scale-research-cohort-key-component-presidents-precision-medicine-initiative|title=NIH framework points the way forward for building national, large-scale research cohort, a key component of the President's Precision Medicine Initiative|date=September 21, 2015|website=National Institutes of Health (NIH)|access-date=April 29, 2016}}
44. ^{{Cite web|url=https://www.whitehouse.gov/the-press-office/2016/02/01/fact-sheet-investing-national-cancer-moonshot|title=FACT SHEET: Investing in the National Cancer Moonshot|date=February 1, 2016|website=whitehouse.gov|access-date=April 29, 2016}}
45. ^{{Cite web|url=https://www.nih.gov/news-events/news-releases/blue-ribbon-panel-announced-help-guide-vice-president-bidens-national-cancer-moonshot-initiative|title=Blue Ribbon Panel Announced to Help Guide Vice President Biden's National Cancer Moonshot Initiative|date=April 4, 2016|website=National Institutes of Health (NIH)|access-date=April 29, 2016}}
46. ^{{cite web|url=http://www.nih.gov/news/health/jun2013/od-26.htm|title=NIH to reduce significantly the use of chimpanzees in research|author=|date=July 28, 2015|website=nih.gov|accessdate=March 29, 2018}}
47. ^{{Cite web|url=https://www.nih.gov/about-nih/who-we-are/nih-director/statements/nih-will-no-longer-support-biomedical-research-chimpanzees|title=NIH Will No Longer Support Biomedical Research on Chimpanzees|date=November 18, 2015|website=National Institutes of Health (NIH)|access-date=April 29, 2016}}
48. ^{{Cite web |url=http://nihrecord.od.nih.gov/newsletters/2013/02_01_2013/story5.htm |title="Big Data, Diversity Initiatives Get Acting Directors," NIH Record, February 1, 2013 |access-date=August 30, 2013 |archive-url=https://web.archive.org/web/20130909053739/http://nihrecord.od.nih.gov/newsletters/2013/02_01_2013/story5.htm |archive-date=September 9, 2013 |dead-url=yes |df=mdy-all }}
49. ^{{Cite web|url=https://www.nih.gov/news-events/news-releases/nih-names-dr-philip-e-bourne-first-associate-director-data-science|title=NIH Names Dr. Philip E. Bourne First Associate Director for Data Science|date=August 10, 2015|website=National Institutes of Health (NIH)|access-date=April 29, 2016}}
50. ^{{cite web |title=Hannah Valantine, M.D., named NIH's first Chief Officer for Scientific Workforce Diversity |url=http://www.nih.gov/news/health/jan2014/od-30.htm |website=News & Events |publisher=National Institutes of Health |accessdate=March 8, 2015 |date=January 20, 2014}}
51. ^{{Cite web|url=https://www.nih.gov/about-nih/nih-wide-strategic-plan|title=NIH-Wide Strategic Plan|date=October 6, 2015|website=National Institutes of Health (NIH)|access-date=April 29, 2016}}
52. ^*"Jesus Goes to Bethesda: Just how religious is Obama's nominee for director of the NIH?". Chris Wilson. Slate. July 9, 2009
53. ^*"Science Writers Entertained By High-Powered Battle Of The Bands" {{webarchive|url=https://web.archive.org/web/20090703174657/http://www.nih.gov/catalyst/back/98.01/battle_of_bands.html |date=July 3, 2009 }}. The NIH Catalyst. Celia Hooper. Jan/Feb 1998.
54. ^{{Cite news |url=http://articles.latimes.com/2010/sep/18/science/la-sci-francis-collins-jams-20100918 |title=To scientists, he's the real rock star |last=Kaplan |first=Karen |date=September 18, 2010 |work=Los Angeles Times |accessdate=}}
55. ^{{Cite news |url=https://www.smu.edu/News/2017/Commencement-Francis-Collins-20may2017 |title=NIH Director Francis Collins addresses SMU students at 102nd Commencement |last=Kaplan |first=Karen |date=May 20, 2017 |accessdate=June 4, 2017}}
56. ^  Rock S.O.S. program, 2009
57. ^{{cite web |last1=Nelson |first1=Richard William |title=The Extinction of "Junk DNA" |date= September 18, 2012 |url=https://www.darwinthenandnow.com/2012/09/the-extinction-of-junk-dna/ |website=Then & Now |accessdate=30 November 2018}}
58. ^{{cite web|title=Biotechnology Heritage Award|url=https://www.sciencehistory.org/biotechnology-heritage-award|website=Science History Institute|accessdate=22 March 2018}}
59. ^{{cite news |last=Strickland |first=Debbie |title=Genomic Leaders Receive 2001 Biotechnology Heritage Award |url=http://www.bio.org/media/press-release/genomic-leaders-receive-2001-biotechnology-heritage-award |accessdate=February 5, 2014 |publisher=BIO |date=June 13, 2001}}
60. ^{{Cite web |url=http://nihrecord.od.nih.gov/newsletters/2007/11_30_2007/story4.htm |title=NIH Record – Collins Wins Presidential Medal of Freedom |access-date=August 2, 2010 |archive-url=https://web.archive.org/web/20100528170001/http://nihrecord.od.nih.gov/newsletters/2007/11_30_2007/story4.htm |archive-date=May 28, 2010 |dead-url=yes |df=mdy-all }}
61. ^"Inamori Ethics Prize, Past Recipients," Case Western Reserve University {{webarchive |url=https://www.webcitation.org/6AaCjPusF?url=http://case.edu/events/inamori/prize/pastrecipients.html |date=2012-09-10 }}
62. ^{{cite web|url=https://www.nsf.gov/od/nms/recip_details.cfm?recip_id=5300000000451|title=The President's National Medal of Science: Recipient Details - NSF - National Science Foundation|author=|date=|website=www.nsf.gov|accessdate=March 29, 2018}}
63. ^"Montgomery County, Maryland, Press Releases {{webarchive |url=https://web.archive.org/web/20061013151412/http://www.montgomerycountymd.gov/mc/news/press/00-463.html |date=October 13, 2006 }}," December 19, 2000, URL accessed January 30, 2007.
64. ^"U.S. News & World Report {{webarchive|url=https://web.archive.org/web/20080123055322/http://www.ksg.harvard.edu/leadership/usnews/genome.html |date=January 23, 2008 }}," 2005, URL accessed February 4, 2008.
65. ^"Dr. Collins' Acceptance Remarks on the Pro Bono Humanum Award of the Galien Foundation," National Institutes of Health, October 16, 2012 {{webarchive|url=https://web.archive.org/web/20130727163644/http://www.nih.gov/about/director/10162012_speech_prixgalien.htm |date=July 27, 2013 }}
66. ^{{cite web|url=http://www.salon.com/2006/08/07/collins_6/|title=The believer|author=|date=August 7, 2006|website=salon.com|accessdate=March 29, 2018}}
67. ^{{cite book |last=Collins |first=Francis |title=The Language of God: A Scientist Presents Evidence for Belief |date=September 4, 2008 |publisher=Simon and Schuster |isbn=9781847396150}}
68. ^{{cite web |url=http://www.colbertnation.com/the-colbert-report-videos/79238/december-07-2006/francis-collins |title=Francis Collins |date=December 6, 2006 |accessdate=October 18, 2009 |publisher=The Colbert Report}}
69. ^{{cite episode |title=Francis Collins on 'The Language of God' |url=https://www.npr.org/templates/story/story.php?storyId=9207913 |series=Fresh Air |serieslink=Fresh Air |airdate=2007-03-29}}
70. ^{{cite web|url=http://www.pointofinquiry.org/dr_francis_collins_the_language_of_god/|title=Dr. Francis Collins - The Language of God|author=D.J. Grothe|publisher=Point of Inquiry|date=August 31, 2007|accessdate=September 3, 2015}}
71. ^{{cite news |url=https://www.nytimes.com/2007/09/27/science/27expelled.html?_r=3&pagewanted=1&oref=slogin |work=The New York Times |title=Scientists Feel Miscast in Film on Life's Origin |first=Cornelia |last=Dean |date=September 27, 2007 |accessdate=May 2, 2010}}
72. ^BioLogos website {{webarchive|url=https://web.archive.org/web/20090902103115/http://biologos.org/news-events/francis-collins-confirmed-as-director-of-the-national-institutes-of-health |date=September 2, 2009 }}
73. ^{{cite web|url=http://veritas.org/speakers/francis-collins/|title=Francis Collins - The Veritas Forum|author=|date=|website=veritas.org|accessdate=March 29, 2018}}
74. ^{{cite web|url=https://www.youtube.com/watch?v=hc6UdA3TtWY|title=Christopher Hitchens says "I'm dying."|last=ilisbaani|date=April 23, 2011|accessdate=March 29, 2018|via=YouTube}}
75. ^Francis Collins: The Scientist as Believer Feb. 2007
76. ^{{cite journal|year=1998|title=Profile: Where Science and Religion Meet|url=|journal=Scientific American|volume=278|issue=2|pages=28–29|author=Beardsley T|doi=10.1038/scientificamerican0298-28}}

Further reading

  • "Dr. Francis S. Collins: On The Trail Of Disease Genes". Businessweek. John Carey. May 9, 2005
  • "Collins Forms BioLogos Foundation". Newsletter of the American Scientific Affiliation. Jul/Aug 2009

External links

{{commons category}}{{Wikiquote|Francis Collins|Francis Collins}}
  • The BioLogos Foundation
  • NIH Bio
  • NHRGI Bio
  • {{C-SPAN|Francis Collins}}
  • {{TED speaker}}
{{S-start}}{{S-gov}}{{s-bef|before=James D. Watson}}{{s-ttl|title=Director of the National Human Genome Research Institute|years=1993 – 2008}}{{s-aft|after=Eric D. Green}}{{s-break}}{{S-bef|before=Raynard Kington
{{small|Acting}}}}{{S-ttl|title=Director of the National Institutes of Health | years=2009 – present}}{{S-inc}}{{S-end}}{{National Institutes of Health}}{{Winners of the National Medal of Science}}{{Authority control}}{{DEFAULTSORT:Collins, Francis}}

24 : 1950 births|Living people|American Christian writers|American expatriates in Nigeria|American geneticists|American physical chemists|Writers about religion and science|Converts to Protestantism from atheism or agnosticism|Critics of creationism|Directors of the National Institutes of Health|Human Genome Project scientists|Members of the International Society for Science and Religion|Members of the Pontifical Academy of Sciences|Members of the United States National Academy of Sciences|People from Staunton, Virginia|Presidential Medal of Freedom recipients|Theistic evolutionists|University of Michigan faculty|University of North Carolina School of Medicine alumni|University of Virginia alumni|Yale University alumni|Members of the National Academy of Medicine|Scientists from Virginia|21st-century Christians

随便看

 

开放百科全书收录14589846条英语、德语、日语等多语种百科知识,基本涵盖了大多数领域的百科知识,是一部内容自由、开放的电子版国际百科全书。

 

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间:2024/9/20 8:12:29