Frank Gaines may refer to:

• Frank S. Gaines (1890–1977), mayor of Berkeley, California, 1939–1943
• Frank Gaines (basketball) (born 1990), American basketball player

• Glutinol synthase
• Glutinous earth tongue
• Glutinous earthtongue
• Glut: Mastering Information Through The Ages
• Glut of excess intended saving
• Glutophrissa
• Glutophrissa contracta
• Glutophrissa drusilla
• Glutton Bowl
• Gluudneset
• Gluzman
• Glušci
• Glušci, Croatia
• Glušica Nikšić
• GL Vir
• GL Virginis
• GLWG
• GLY1
• Glyaden
• GLYAT (gene)
• Glyben
• Glybenclamide
• Glybenzcyclamide
• Glybera
• Glybigid