| 释义 |
- References
- Further reading
- External links
{{Underlinked|date=May 2016}}{{Infobox_gene}}Proto-oncogene FRAT1 is a protein that in humans is encoded by the FRAT1 gene.[1][2]The protein encoded by this gene belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis.[2] References1. ^{{cite journal | vauthors = Jonkers J, Korswagen HC, Acton D, Breuer M, Berns A | title = Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas | journal = EMBO J | volume = 16 | issue = 3 | pages = 441–50 |date=Mar 1997 | pmid = 9034327 | pmc = 1169648 | doi = 10.1093/emboj/16.3.441 }}
2. ^1 {{cite web | title = Entrez Gene: FRAT1 frequently rearranged in advanced T-cell lymphomas| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10023| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Li L, Yuan H, Weaver CD |title=Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. |journal=EMBO J. |volume=18 |issue= 15 |pages= 4233–40 |year= 1999 |pmid= 10428961 |doi= 10.1093/emboj/18.15.4233 | pmc=1171499 |display-authors=etal}}
- {{cite journal | vauthors=Saitoh T, Katoh M |title=FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. |journal=Int. J. Oncol. |volume=19 |issue= 2 |pages= 311–5 |year= 2001 |pmid= 11445844 |doi= 10.3892/ijo.19.2.311}}
- {{cite journal | vauthors=Bax B, Carter PS, Lewis C |title=The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. |journal=Structure |volume=9 |issue= 12 |pages= 1143–52 |year= 2002 |pmid= 11738041 |doi=10.1016/S0969-2126(01)00679-7 |display-authors=etal}}
- {{cite journal | vauthors=Saitoh T, Mine T, Katoh M |title=Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. |journal=Int. J. Oncol. |volume=20 |issue= 4 |pages= 785–9 |year= 2002 |pmid= 11894125 |doi= 10.3892/ijo.20.4.785}}
- {{cite journal | vauthors=Freemantle SJ, Portland HB, Ewings K |title=Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. |journal=Gene |volume=291 |issue= 1-2 |pages= 17–27 |year= 2002 |pmid= 12095675 |doi=10.1016/S0378-1119(02)00594-2 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Hino S, Michiue T, Asashima M, Kikuchi A |title=Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 14066–73 |year= 2003 |pmid= 12556519 |doi= 10.1074/jbc.M213265200 }}
- {{cite journal | vauthors=Khambata-Ford S, Liu Y, Gleason C |title=Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. |journal=Genome Res. |volume=13 |issue= 7 |pages= 1765–74 |year= 2003 |pmid= 12805274 |doi= 10.1101/gr.529803 | pmc=403750 |display-authors=etal}}
- {{cite journal | vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Wang Y, Hewitt SM, Liu S |title=Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. |journal=Br. J. Cancer |volume=94 |issue= 5 |pages= 686–91 |year= 2006 |pmid= 16479254 |doi= 10.1038/sj.bjc.6602988 | pmc=2361213 |display-authors=etal}}
- {{cite journal | vauthors=Hagen T, Cross DA, Culbert AA |title=FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. |journal=J. Biol. Chem. |volume=281 |issue= 46 |pages= 35021–9 |year= 2007 |pmid= 16982607 |doi= 10.1074/jbc.M607003200 |display-authors=etal}}
{{refend}}External links- {{UCSC genome browser|FRAT1}}
- {{UCSC gene details|FRAT1}}
{{PDB Gallery|geneid=10023}}{{gene-10-stub}} |