| 释义 |
- References
- Further reading
{{Underlinked|date=May 2016}}{{Infobox_gene}}GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.[1][2][3]The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.[4] References1. ^{{cite journal | vauthors = Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D | title = GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis | journal = Cell | volume = 93 | issue = 6 | pages = 1031–41 |date=Jul 1998 | pmid = 9635432 | pmc = | doi =10.1016/S0092-8674(00)81208-8 }}
2. ^{{cite journal | vauthors = Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M | title = Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway | journal = Biochem Biophys Res Commun | volume = 281 | issue = 3 | pages = 815–20 |date=Mar 2001 | pmid = 11237732 | pmc = | doi = 10.1006/bbrc.2001.4421 }}
3. ^{{cite web | title = Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23401| accessdate = }}
4. ^{{cite web | title = Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23401| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal | vauthors=Bax B, Carter PS, Lewis C |title=The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation. |journal=Structure |volume=9 |issue= 12 |pages= 1143–52 |year= 2002 |pmid= 11738041 |doi=10.1016/S0969-2126(01)00679-7 |display-authors=etal}}
- {{cite journal | vauthors=Freemantle SJ, Portland HB, Ewings K |title=Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2. |journal=Gene |volume=291 |issue= 1-2 |pages= 17–27 |year= 2002 |pmid= 12095675 |doi=10.1016/S0378-1119(02)00594-2 |display-authors=etal}}
- {{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal | vauthors=Deloukas P, Earthrowl ME, Grafham DV |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 |display-authors=etal}}
- {{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal | vauthors=Stoothoff WH, Cho JH, McDonald RP, Johnson GV |title=FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. |journal=J. Biol. Chem. |volume=280 |issue= 1 |pages= 270–6 |year= 2005 |pmid= 15522877 |doi= 10.1074/jbc.M410061200 }}
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