“Free fatty acid receptor 3”的意思、由来-开放百科全书

Knockout mouse studies have implicated FFAR3 in diabetes,^[3] colitis,^[4] hypertension^[5] and asthma.^[6] However, discrepancies between the pathways activated by FFAR3 agonists in human cells and the equivalent murine counterparts have been observed.^[7]

Heteromerization

FFAR3 may interact with FFAR2 to form a FFAR2-FFAR3 receptor heteromer with signalling that is distinct from the parent homomers.^[8]

See also

References

1. ^{{cite web | title = Entrez Gene: FFAR3 free fatty acid receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2865| accessdate = }}
2. ^{{cite journal | vauthors = Sawzdargo M, George SR, Nguyen T, Xu S, Kolakowski LF, O'Dowd BF | title = A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1 | journal = Biochemical and Biophysical Research Communications | volume = 239 | issue = 2 | pages = 543–7 | date = October 1997 | pmid = 9344866 | doi = 10.1006/bbrc.1997.7513 }}
3. ^{{cite journal | vauthors = Tang C, Ahmed K, Gille A, Lu S, Gröne HJ, Tunaru S, Offermanns S | title = Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes | journal = Nature Medicine | volume = 21 | issue = 2 | pages = 173–7 | date = February 2015 | pmid = 25581519 | doi = 10.1038/nm.3779 }}
4. ^{{cite journal | vauthors = Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH | title = Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice | journal = Gastroenterology | volume = 145 | issue = 2 | pages = 396–406.e1-10 | date = August 2013 | pmid = 23665276 | doi = 10.1053/j.gastro.2013.04.056 }}
5. ^{{cite journal | vauthors = Natarajan N, Hori D, Flavahan S, Steppan J, Flavahan NA, Berkowitz DE, Pluznick JL | title = Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41 | journal = Physiological Genomics | volume = 48 | issue = 11 | pages = 826–834 | date = November 2016 | pmid = 27664183 | doi = 10.1152/physiolgenomics.00089.2016 }}
6. ^{{cite journal | vauthors = Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, Marsland BJ | title = Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis | journal = Nature Medicine | volume = 20 | issue = 2 | pages = 159–66 | date = February 2014 | pmid = 24390308 | doi = 10.1038/nm.3444 }}
7. ^{{cite journal | vauthors = Ang Z, Er JZ, Tan NS, Lu J, Liou YC, Grosse J, Ding JL | title = Human and mouse monocytes display distinct signalling and cytokine profiles upon stimulation with FFAR2/FFAR3 short-chain fatty acid receptor agonists | journal = Scientific Reports | volume = 6 | pages = 34145 | date = September 2016 | pmid = 27667443 | pmc = 5036191 | doi = 10.1038/srep34145 }}
8. ^{{cite journal | vauthors = Ang Z, Xiong D, Wu M, Ding JL | title = FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing | journal = FASEB Journal | pages = –201700252RR | date = September 2017 | pmid = 28883043 | doi = 10.1096/fj.201700252RR | url = http://www.fasebj.org/content/early/2017/09/07/fj.201700252RR | volume=32 | pmc=5731126}}

Further reading

{{cite journal | vauthors = Brown AJ, Jupe S, Briscoe CP | title = A family of fatty acid binding receptors | journal = DNA and Cell Biology | volume = 24 | issue = 1 | pages = 54–61 | date = January 2005 | pmid = 15684720 | doi = 10.1089/dna.2005.24.54 }}

{{cite journal | vauthors = Brown AJ, Goldsworthy SM, Barnes AA, Eilert MM, Tcheang L, Daniels D, Muir AI, Wigglesworth MJ, Kinghorn I, Fraser NJ, Pike NB, Strum JC, Steplewski KM, Murdock PR, Holder JC, Marshall FH, Szekeres PG, Wilson S, Ignar DM, Foord SM, Wise A, Dowell SJ | title = The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids | journal = The Journal of Biological Chemistry | volume = 278 | issue = 13 | pages = 11312–9 | date = March 2003 | pmid = 12496283 | doi = 10.1074/jbc.M211609200 }}

{{cite journal | vauthors = Le Poul E, Loison C, Struyf S, Springael JY, Lannoy V, Decobecq ME, Brezillon S, Dupriez V, Vassart G, Van Damme J, Parmentier M, Detheux M | title = Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 25481–9 | date = July 2003 | pmid = 12711604 | doi = 10.1074/jbc.M301403200 }}

{{cite journal | vauthors = Xiong Y, Miyamoto N, Shibata K, Valasek MA, Motoike T, Kedzierski RM, Yanagisawa M | title = Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 4 | pages = 1045–50 | date = January 2004 | pmid = 14722361 | pmc = 327148 | doi = 10.1073/pnas.2637002100 }}

{{cite journal | vauthors = Yonezawa T, Kobayashi Y, Obara Y | title = Short-chain fatty acids induce acute phosphorylation of the p38 mitogen-activated protein kinase/heat shock protein 27 pathway via GPR43 in the MCF-7 human breast cancer cell line | journal = Cellular Signalling | volume = 19 | issue = 1 | pages = 185–93 | date = January 2007 | pmid = 16887331 | doi = 10.1016/j.cellsig.2006.06.004 }}

1 : G protein-coupled receptors

Animal studies

Heteromerization

See also

References

Further reading