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词条 FSTL1
释义

  1. Structure

  2. Clinical significance

      Development    Arthritis   Cardiovascular diseases 

  3. References

  4. Further reading

{{Infobox_gene}}Follistatin-related protein 1 is a protein that in humans is encoded by the FSTL1 gene.[1][2][3]

Structure

This gene encodes a protein with similarity to follistatin, an BMP-4-binding protein.[4] It binds to BMP-4 and TGF-β1, but not Activin A.[4] It contains an FS module (a follistatin-like sequence containing 10 conserved cysteine residues), a Kazal-type serine protease inhibitor domain, 2 EF hand domains, and a Von Willebrand factor type C domain.[3]

Clinical significance

Development

FSTL1 has a role in development,[5][6] such as lung development,[4][7] ureter development,[8] central nervous system development,[9] and skeletal development.[7]

Arthritis

This gene product is thought to be an autoantigen associated with rheumatoid arthritis.[3]

FSTL1 up-regulates proinflammatory mediators important in the pathology of arthritis, and serum levels of FSTL1 correlate with severity of arthritis.[10][11][12]

Cardiovascular diseases

FSTL1 protein seems to have a cardioprotective role. FSTL1 attenuated hypertrophy following pressure overload[13] and prevented myocardial ischemia/reperfusion injury in a mouse or pig model of ischemia/reperfusion.[14] Muscle-derived Fstl1 modulates vascular remodelling in response to injury.[15]

{{Clear}}

FSTL1 has been shown to have a pronounced ability as a possible therapeutic to stimulate regeneration following myocardial infarction. Treating experimental animals (mouse and pig) with FSTL1 after myocardial infarction progressively restored heart function, at least in part by stimulating replication of normally non-dividing heart muscle cells[16]

References

1. ^{{cite journal | vauthors = Zwijsen A, Blockx H, Van Arnhem W, Willems J, Fransen L, Devos K, Raymackers J, Van de Voorde A, Slegers H | title = Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue | journal = European Journal of Biochemistry / FEBS | volume = 225 | issue = 3 | pages = 937–46 | date = Nov 1994 | pmid = 7957230 | pmc = | doi = 10.1111/j.1432-1033.1994.0937b.x }}
2. ^{{cite journal | vauthors = Tanaka M, Ozaki S, Osakada F, Mori K, Okubo M, Nakao K | title = Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases | journal = International Immunology | volume = 10 | issue = 9 | pages = 1305–14 | date = Sep 1998 | pmid = 9786430 | pmc = | doi = 10.1093/intimm/10.9.1305 }}
3. ^1 2 {{cite web | title = Entrez Gene: FSTL1 follistatin-like 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11167| accessdate = }}
4. ^1 2 {{cite journal | vauthors = Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W | title = Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 17 | pages = 7058–63 | date = Apr 2011 | pmid = 21482757 | doi = 10.1073/pnas.1007293108 | pmc=3084141}}
5. ^{{cite journal | vauthors = Umezu T, Yamanouchi H, Iida Y, Miura M, Tomooka Y | title = Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 107 | issue = 10 | pages = 4601–6 | date = Mar 2010 | pmid = 20176958 | doi = 10.1073/pnas.0909501107 | pmc=2842048}}
6. ^{{cite journal | vauthors = Sylva M, Moorman AF, van den Hoff MJ | title = Follistatin-like 1 in vertebrate development | journal = Birth Defects Research. Part C, Embryo Today | volume = 99 | issue = 1 | pages = 61–9 | date = Mar 2013 | pmid = 23723173 | doi = 10.1002/bdrc.21030 }}
7. ^1 {{cite journal | vauthors = Sylva M, Li VS, Buffing AA, van Es JH, van den Born M, van der Velden S, Gunst Q, Koolstra JH, Moorman AF, Clevers H, van den Hoff MJ | title = The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis | journal = PLOS ONE | volume = 6 | issue = 8 | pages = e22616 | date = 3 August 2011 | pmid = 21826198 | doi = 10.1371/journal.pone.0022616 | pmc=3149603}}
8. ^{{cite journal | vauthors = Xu J, Qi X, Gong J, Yu M, Zhang F, Sha H, Gao X | title = Fstl1 antagonizes BMP signaling and regulates ureter development | journal = PLOS ONE | volume = 7 | issue = 4 | pages = e32554 | date = 2012 | pmid = 22485132 | doi = 10.1371/journal.pone.0032554 | pmc=3317656}}
9. ^{{cite journal | vauthors = Yang Y, Liu J, Mao H, Hu YA, Yan Y, Zhao C | title = The expression pattern of Follistatin-like 1 in mouse central nervous system development | journal = Gene Expression Patterns | volume = 9 | issue = 7 | pages = 532–40 | date = Oct 2009 | pmid = 19595790 | doi = 10.1016/j.gep.2009.07.001 }}
10. ^{{cite journal | vauthors = Chaly Y, Marinov AD, Oxburgh L, Bushnell DS, Hirsch R | title = FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression | journal = Arthritis and Rheumatism | volume = 64 | issue = 4 | pages = 1082–8 | date = Apr 2012 | pmid = 22006268 | pmc = 3276726 | doi = 10.1002/art.33422 }}
11. ^{{cite journal | vauthors = Chaly Y, Blair HC, Smith SM, Bushnell DS, Marinov AD, Campfield BT, Hirsch R | title = Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells | journal = Annals of the Rheumatic Diseases | volume = 74 | issue = 7 | pages = 1467–73 | date = Jul 2015 | pmid = 24641944 | doi = 10.1136/annrheumdis-2013-204822 }}
12. ^{{cite journal | vauthors = Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield B, Kellum JA, Bushnell D, Wang Y, Vockley J, Hirsch R | title = Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages | journal = European Journal of Immunology | volume = 44 | issue = 5 | pages = 1467–79 | date = May 2014 | pmid = 24470197 | doi = 10.1002/eji.201344063 | pmc = 4004659 }}
13. ^{{cite journal | vauthors = Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K | title = Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 108 | issue = 43 | pages = E899–906 | date = Oct 2011 | pmid = 21987816 | doi = 10.1073/pnas.1108559108 | pmc=3203781}}
14. ^{{cite journal | vauthors = Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T | title = Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models | journal = Circulation | volume = 126 | issue = 14 | pages = 1728–38 | date = Oct 2012 | pmid = 22929303 | doi = 10.1161/CIRCULATIONAHA.112.115089 | pmc=3548325}}
15. ^{{cite journal | vauthors = Miyabe M, Ohashi K, Shibata R, Uemura Y, Ogura Y, Yuasa D, Kambara T, Kataoka Y, Yamamoto T, Matsuo K, Joki Y, Enomoto T, Hayakawa S, Hiramatsu-Ito M, Ito M, Van Den Hoff MJ, Walsh K, Murohara T, Ouchi N | title = Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury | journal = Cardiovascular Research | volume = 103 | issue = 1 | pages = 111–20 | date = Jul 2014 | pmid = 24743592 | doi = 10.1093/cvr/cvu105 | pmc=4834864}}
16. ^{{cite journal | vauthors = Wei K, Serpooshan V, Hurtado C, Diez-Cuñado M, Zhao M, Maruyama S, Zhu W, Fajardo G, Noseda M, Nakamura K, Tian X, Liu Q, Wang A, Matsuura Y, Bushway P, Cai W, Savchenko A, Mahmoudi M, Schneider MD, van den Hoff MJ, Butte MJ, Yang PC, Walsh K, Zhou B, Bernstein D, Mercola M, Ruiz-Lozano P | date = Sep 2015 | title = Epicardial FSTL1 reconstitution regenerates the adult mammalian heart | journal = Nature | volume = 525 | issue = 7570| pages = 479–85 | doi = 10.1038/nature15372 | pmid=26375005 | pmc=4762253}}

Further reading

{{refbegin|33em}}
  • {{cite journal | vauthors = Vertegaal AC, Kuiperij HB, van Laar T, Scharnhorst V, van der Eb AJ, Zantema A | title = cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells | journal = FEBS Letters | volume = 487 | issue = 2 | pages = 151–5 | date = Dec 2000 | pmid = 11150499 | doi = 10.1016/S0014-5793(00)02339-5 }}
  • {{cite journal | vauthors = Ciarmela P, Florio P, Sigurdardottir M, Toti P, Maguer-Satta V, Rimokh R, Altomare A, Tosi P, Petraglia F | title = Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma | journal = European Journal of Endocrinology / European Federation of Endocrine Societies | volume = 151 | issue = 2 | pages = 251–7 | date = Aug 2004 | pmid = 15296481 | doi = 10.1530/eje.0.1510251 }}
  • {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = Oct 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
  • {{cite journal | vauthors = Ehara Y, Sakurai D, Tsuchiya N, Nakano K, Tanaka Y, Yamaguchi A, Tokunaga K | title = Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility | journal = Clinical and Experimental Rheumatology | volume = 22 | issue = 6 | pages = 707–12 | year = 2005 | pmid = 15638044 | doi = }}
  • {{cite journal | vauthors = Liu S, Wang L, Wang W, Lin J, Han J, Sun H, Guo H, Sun R, Wu Q | title = TSC-36/FRP inhibits vascular smooth muscle cell proliferation and migration | journal = Experimental and Molecular Pathology | volume = 80 | issue = 2 | pages = 132–40 | date = Apr 2006 | pmid = 16256108 | doi = 10.1016/j.yexmp.2005.07.005 }}
  • {{cite journal | vauthors = Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD | title = Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry | journal = Journal of Proteome Research | volume = 4 | issue = 6 | pages = 2070–80 | year = 2006 | pmid = 16335952 | pmc = 1850943 | doi = 10.1021/pr0502065 }}
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1 : EF-hand-containing proteins
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