| 释义 |
- Function
- Interactions
- See also
- References
- Further reading
{{Infobox_gene}}Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.[1][2] Function This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.[2] Interactions FTH1 has been shown to interact with Ferritin light chain.[3][4] See also References 1. ^{{cite journal | vauthors = Hentze MW, Keim S, Papadopoulos P, O'Brien S, Modi W, Drysdale J, Leonard WJ, Harford JB, Klausner RD | title = Cloning, characterization, expression, and chromosomal localization of a human ferritin heavy-chain gene | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 19 | pages = 7226–30 | date = Oct 1986 | pmid = 3020541 | pmc = 386688 | doi = 10.1073/pnas.83.19.7226 }}
2. ^1 {{cite web | title = Entrez Gene: FTH1 ferritin, heavy polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2495| accessdate = }}
3. ^{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
4. ^{{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Percy ME, Wong S, Bauer S, Liaghati-Nasseri N, Perry MD, Chauthaiwale VM, Dhar M, Joshi JG | title = Iron metabolism and human ferritin heavy chain cDNA from adult brain with an elongated untranslated region: new findings and insights | journal = The Analyst | volume = 123 | issue = 1 | pages = 41–50 | date = Jan 1998 | pmid = 9581019 | doi = 10.1039/a706355e }}
- {{cite journal | vauthors = Arosio P, Adelman TG, Drysdale JW | title = On ferritin heterogeneity. Further evidence for heteropolymers | journal = The Journal of Biological Chemistry | volume = 253 | issue = 12 | pages = 4451–8 | date = Jun 1978 | pmid = 659425 | doi = }}
- {{cite journal | vauthors = Lawson DM, Artymiuk PJ, Yewdall SJ, Smith JM, Livingstone JC, Treffry A, Luzzago A, Levi S, Arosio P, Cesareni G | title = Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts | journal = Nature | volume = 349 | issue = 6309 | pages = 541–4 | date = Feb 1991 | pmid = 1992356 | doi = 10.1038/349541a0 }}
- {{cite journal | vauthors = Costanzo F, Colombo M, Staempfli S, Santoro C, Marone M, Frank R, Delius H, Cortese R | title = Structure of gene and pseudogenes of human apoferritin H | journal = Nucleic Acids Research | volume = 14 | issue = 2 | pages = 721–36 | date = Jan 1986 | pmid = 3003694 | pmc = 339460 | doi = 10.1093/nar/14.2.721 }}
- {{cite journal | vauthors = Chou CC, Gatti RA, Fuller ML, Concannon P, Wong A, Chada S, Davis RC, Salser WA | title = Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro | journal = Molecular and Cellular Biology | volume = 6 | issue = 2 | pages = 566–73 | date = Feb 1986 | pmid = 3023856 | pmc = 367547 | doi = 10.1128/mcb.6.2.566}}
- {{cite journal | vauthors = Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, Klausner RD | title = Identification of the iron-responsive element for the translational regulation of human ferritin mRNA | journal = Science | volume = 238 | issue = 4833 | pages = 1570–3 | date = Dec 1987 | pmid = 3685996 | doi = 10.1126/science.3685996 }}
- {{cite journal | vauthors = Boyd D, Vecoli C, Belcher DM, Jain SK, Drysdale JW | title = Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones | journal = The Journal of Biological Chemistry | volume = 260 | issue = 21 | pages = 11755–61 | date = Sep 1985 | pmid = 3840162 | doi = }}
- {{cite journal | vauthors = Worwood M, Brook JD, Cragg SJ, Hellkuhl B, Jones BM, Perera P, Roberts SH, Shaw DJ | title = Assignment of human ferritin genes to chromosomes 11 and 19q13.3----19qter | journal = Human Genetics | volume = 69 | issue = 4 | pages = 371–4 | year = 1985 | pmid = 3857215 | doi = 10.1007/BF00291657 }}
- {{cite journal | vauthors = Dörner MH, Salfeld J, Will H, Leibold EA, Vass JK, Munro HN | title = Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 82 | issue = 10 | pages = 3139–43 | date = May 1985 | pmid = 3858810 | pmc = 397730 | doi = 10.1073/pnas.82.10.3139 }}
- {{cite journal | vauthors = Costanzo F, Santoro C, Colantuoni V, Bensi G, Raugei G, Romano V, Cortese R | title = Cloning and sequencing of a full length cDNA coding for a human apoferritin H chain: evidence for a multigene family | journal = The EMBO Journal | volume = 3 | issue = 1 | pages = 23–7 | date = Jan 1984 | pmid = 6323167 | pmc = 557292 | doi = }}
- {{cite journal | vauthors = Boyd D, Jain SK, Crampton J, Barrett KJ, Drysdale J | title = Isolation and characterization of a cDNA clone for human ferritin heavy chain | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 81 | issue = 15 | pages = 4751–5 | date = Aug 1984 | pmid = 6589621 | pmc = 391568 | doi = 10.1073/pnas.81.15.4751 }}
- {{cite journal | vauthors = Addison JM, Fitton JE, Lewis WG, May K, Harrison PM | title = The amino acid sequence of human liver apoferritin | journal = FEBS Letters | volume = 164 | issue = 1 | pages = 139–44 | date = Nov 1983 | pmid = 6653779 | doi = 10.1016/0014-5793(83)80037-4 }}
- {{cite journal | vauthors = Dhar MS, Joshi JG | title = Differential processing of the ferritin heavy chain mRNA in human liver and adult human brain | journal = Journal of Neurochemistry | volume = 61 | issue = 6 | pages = 2140–6 | date = Dec 1993 | pmid = 7504084 | doi = 10.1111/j.1471-4159.1993.tb07452.x }}
- {{cite journal | vauthors = Connor JR, Snyder BS, Arosio P, Loeffler DA, LeWitt P | title = A quantitative analysis of isoferritins in select regions of aged, parkinsonian, and Alzheimer's diseased brains | journal = Journal of Neurochemistry | volume = 65 | issue = 2 | pages = 717–24 | date = Aug 1995 | pmid = 7616228 | doi = 10.1046/j.1471-4159.1995.65020717.x }}
- {{cite journal | vauthors = Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T | title = Construction of a human full-length cDNA bank | journal = Gene | volume = 150 | issue = 2 | pages = 243–50 | date = Dec 1994 | pmid = 7821789 | doi = 10.1016/0378-1119(94)90433-2 }}
- {{cite journal | vauthors = Dhar M, Chauthaiwale V, Joshi JG | title = Sequence of a cDNA encoding the ferritin H-chain from an 11-week-old human fetal brain | journal = Gene | volume = 126 | issue = 2 | pages = 275–8 | date = Apr 1993 | pmid = 7916709 | doi = 10.1016/0378-1119(93)90380-L }}
- {{cite journal | vauthors = Qi Y, Dawson G | title = Hypoxia specifically and reversibly induces the synthesis of ferritin in oligodendrocytes and human oligodendrogliomas | journal = Journal of Neurochemistry | volume = 63 | issue = 4 | pages = 1485–90 | date = Oct 1994 | pmid = 7931301 | doi = 10.1046/j.1471-4159.1994.63041485.x }}
- {{cite journal | vauthors = Rogers JT | title = Ferritin translation by interleukin-1and interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes | journal = Blood | volume = 87 | issue = 6 | pages = 2525–37 | date = Mar 1996 | pmid = 8630420 | doi = }}
- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
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