| 释义 |
- Interactions
- References
- Further reading
{{Infobox_gene}}Fyn-related kinase (FRK, formerly tyrosine protein kinase 5) is an enzyme that in humans is encoded by the FRK gene.[1][2]The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.[2] InteractionsFRK has been shown to interact with retinoblastoma protein.[3] References1. ^{{cite journal |vauthors=Lee J, Wang Z, Luoh SM, Wood WI, Scadden DT | title = Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene | journal = Gene | volume = 138 | issue = 1-2 | pages = 247–51 |date=April 1994 | pmid = 7510261 | pmc = | doi = 10.1016/0378-1119(94)90817-6}}
2. ^1 {{cite web | title = Entrez Gene: FRK fyn-related kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2444| accessdate = }}
3. ^{{cite journal |last=Craven |first=R J |authorlink= |author2=Cance W G|author3=Liu E T |date=September 1995 |title=The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb |journal=Cancer Res. |volume=55 |issue=18 |pages=3969–72 |publisher= |location = UNITED STATES| issn = 0008-5472| pmid = 7664264 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Serfas MS, Tyner AL |title=Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. |journal=Oncol. Res. |volume=13 |issue= 6-10 |pages= 409–19 |year= 2003 |pmid= 12725532 |doi= }}
- {{cite journal |vauthors=Craven RJ, Cance WG, Liu ET |title=The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb. |journal=Cancer Res. |volume=55 |issue= 18 |pages= 3969–72 |year= 1995 |pmid= 7664264 |doi= }}
- {{cite journal |vauthors=Cance WG, Craven RJ, Bergman M |title=Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. |journal=Cell Growth Differ. |volume=5 |issue= 12 |pages= 1347–55 |year= 1995 |pmid= 7696183 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Cance WG, Craven RJ, Weiner TM, Liu ET |title=Novel protein kinases expressed in human breast cancer. |journal=Int. J. Cancer |volume=54 |issue= 4 |pages= 571–7 |year= 1993 |pmid= 8099900 |doi=10.1002/ijc.2910540409 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241|display-authors=etal|bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Meyer T, Xu L, Chang J |title=Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase. |journal=Int. J. Cancer |volume=104 |issue= 2 |pages= 139–46 |year= 2003 |pmid= 12569567 |doi= 10.1002/ijc.10925 |display-authors=etal}}
- {{cite journal |vauthors=Watanabe T, Ohnuma T, Shibata N |title=No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease. |journal=Neurosci. Lett. |volume=360 |issue= 1-2 |pages= 109–11 |year= 2004 |pmid= 15082191 |doi= 10.1016/j.neulet.2004.02.046 |display-authors=etal}}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928|display-authors=etal}}
- {{cite journal |vauthors=Zhang Y, Wolf-Yadlin A, Ross PL |title=Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. |journal=Mol. Cell. Proteomics |volume=4 |issue= 9 |pages= 1240–50 |year= 2005 |pmid= 15951569 |doi= 10.1074/mcp.M500089-MCP200 |display-authors=etal}}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }}
{{refend}}{{Tyrosine kinases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{gene-6-stub}} 1 : Tyrosine kinases |