| 释义 |
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Frizzled-5 is a protein that in humans is encoded by the FZD5 gene.[1][2][3]Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.[3] See alsoReferences1. ^{{cite journal |vauthors=Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J | title = A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled | journal = J Biol Chem | volume = 271 | issue = 8 | pages = 4468–76 |date=Jun 1996 | pmid = 8626800 | pmc = | doi =10.1074/jbc.271.8.4468 }}
2. ^{{cite journal |vauthors=Saitoh T, Hirai M, Katoh M | title = Molecular cloning and characterization of human Frizzled-5 gene on chromosome 2q33.3-q34 region | journal = Int J Oncol | volume = 19 | issue = 1 | pages = 105–10 |date=Jun 2001 | pmid = 11408929 | pmc = | doi = 10.3892/ijo.19.1.105}}
3. ^1 {{cite web | title = Entrez Gene: FZD5 frizzled homolog 5 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7855| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=He X, Saint-Jeannet JP, Wang Y |title=A member of the Frizzled protein family mediating axis induction by Wnt-5A. |journal=Science |volume=275 |issue= 5306 |pages= 1652–4 |year= 1997 |pmid= 9054360 |doi=10.1126/science.275.5306.1652 |display-authors=etal}}
- {{cite journal |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770 | pmc=21233 |display-authors=etal}}
- {{cite journal |vauthors=Tanaka S, Akiyoshi T, Mori M |title=A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 10164–9 |year= 1998 |pmid= 9707618 |doi=10.1073/pnas.95.17.10164 | pmc=21479 |display-authors=etal}}
- {{cite journal |vauthors=Tamai K, Semenov M, Kato Y |title=LDL-receptor-related proteins in Wnt signal transduction. |journal=Nature |volume=407 |issue= 6803 |pages= 530–5 |year= 2000 |pmid= 11029007 |doi= 10.1038/35035117 |display-authors=etal}}
- {{cite journal |vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R | pmc=311072 |display-authors=etal}}
- {{cite journal |vauthors=Yao R, Maeda T, Takada S, Noda T |title=Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 4 |pages= 771–8 |year= 2001 |pmid= 11520064 |doi= 10.1006/bbrc.2001.5430 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
- {{cite journal |vauthors=Weidler C, Schaumburger J, Miller LE |title=Synovial density of frizzled 5-positive cells does not differ between patients with RA and OA and is independent of inflammation. |journal=J. Rheumatol. |volume=31 |issue= 9 |pages= 1874–5 |year= 2004 |pmid= 15338479 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |display-authors=etal}}
- {{cite journal |vauthors=Holmen SL, Robertson SA, Zylstra CR, Williams BO |title=Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 533–9 |year= 2005 |pmid= 15694380 |doi= 10.1016/j.bbrc.2005.01.009 }}
- {{cite journal |vauthors=Hillier LW, Graves TA, Fulton RS |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 |display-authors=etal}}
- {{cite journal |vauthors=Blumenthal A, Ehlers S, Lauber J |title=The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. |journal=Blood |volume=108 |issue= 3 |pages= 965–73 |year= 2006 |pmid= 16601243 |doi= 10.1182/blood-2005-12-5046 |display-authors=etal}}
- {{cite journal |vauthors=Yamamoto H, Komekado H, Kikuchi A |title=Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. |journal=Dev. Cell |volume=11 |issue= 2 |pages= 213–23 |year= 2006 |pmid= 16890161 |doi= 10.1016/j.devcel.2006.07.003 }}
- {{cite journal |vauthors=Katoh Y, Katoh M |title=Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. |journal=Int. J. Oncol. |volume=30 |issue= 3 |pages= 751–5 |year= 2007 |pmid= 17273778 |doi= 10.3892/ijo.30.3.751}}
{{refend}}External links- {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3063 | title = Frizzled Receptors: FZD5 | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
{{NLM content}}{{G protein-coupled receptors|g4}}{{transmembranereceptor-stub}} 1 : G protein-coupled receptors |