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词条 FZD6
释义

  1. Interactions

  2. See also

  3. Model organisms

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}Frizzled-6 is a protein that in humans is encoded by the FZD6 gene.[1][2][3]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif.[3] The FZD6 protein is believed to be the receptor for the WNT4 ligand.[4]

Interactions

FZD6 has been shown to interact with Secreted frizzled-related protein 1.[5]

See also

  • Frizzled

Model organisms

Model organisms have been used in the study of FXYD3 function. In 2004, researchers at the Howard Hughes Medical Institute showed that FZD6 controls hair patterning in mice,[6] and its human homologue is understood to play a part in the formation of hair whorls and cowlicks. A conditional knockout mouse line called Fxyd3tm1a(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[7] Male and female animals underwent a standardized phenotypic screen[8] to determine the effects of deletion.[9][10][11][12] Additional screens performed: - In-depth immunological phenotyping[13]{{clear|left}}

References

1. ^{{cite journal | vauthors = Tokuhara M, Hirai M, Atomi Y, Terada M, Katoh M | title = Molecular cloning of human Frizzled-6 | journal = Biochemical and Biophysical Research Communications | volume = 243 | issue = 2 | pages = 622–7 | date = Feb 1998 | pmid = 9480858 | pmc = | doi = 10.1006/bbrc.1998.8143 }}
2. ^{{cite journal | vauthors = Golan T, Yaniv A, Bafico A, Liu G, Gazit A | title = The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade | journal = The Journal of Biological Chemistry | volume = 279 | issue = 15 | pages = 14879–88 | date = Apr 2004 | pmid = 14747478 | pmc = | doi = 10.1074/jbc.M306421200 }}
3. ^1 {{cite web | title = Entrez Gene: FZD6 frizzled homolog 6 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8323| accessdate = }}
4. ^{{cite journal | vauthors = Lyons JP, Mueller UW, Ji H, Everett C, Fang X, Hsieh JC, Barth AM, McCrea PD | title = Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells | journal = Experimental Cell Research | volume = 298 | issue = 2 | pages = 369–87 | date = Aug 2004 | pmid = 15265686 | pmc = | doi = 10.1016/j.yexcr.2004.04.036 }}
5. ^{{cite journal | vauthors = Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA | title = Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16180–7 | date = Jun 1999 | pmid = 10347172 | doi = 10.1074/jbc.274.23.16180 }}
6. ^{{cite web | title = Frizzled6 controls hair patterning in mice| url = http://www.pnas.org/content/101/25/9277}}
7. ^{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}
8. ^1 {{cite web |url=http://www.mousephenotype.org/data/search?q=Fxyd3#fq=**&facet=gene |title=International Mouse Phenotyping Consortium}}
9. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
10. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
11. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
12. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}
13. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Fxyd3&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}

Further reading

{{refbegin|33em}}
  • {{cite journal | vauthors = Wang Y, Macke JP, Abella BS, Andreasson K, Worley P, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J | title = A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled | journal = The Journal of Biological Chemistry | volume = 271 | issue = 8 | pages = 4468–76 | date = Feb 1996 | pmid = 8626800 | doi = 10.1074/jbc.271.8.4468 }}
  • {{cite journal | vauthors = Finch PW, He X, Kelley MJ, Uren A, Schaudies RP, Popescu NC, Rudikoff S, Aaronson SA, Varmus HE, Rubin JS | title = Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 13 | pages = 6770–5 | date = Jun 1997 | pmid = 9192640 | pmc = 21233 | doi = 10.1073/pnas.94.13.6770 }}
  • {{cite journal | vauthors = Bafico A, Gazit A, Pramila T, Finch PW, Yaniv A, Aaronson SA | title = Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16180–7 | date = Jun 1999 | pmid = 10347172 | doi = 10.1074/jbc.274.23.16180 }}
  • {{cite journal | vauthors = Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y | title = Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) | journal = Ophthalmic Genetics | volume = 25 | issue = 2 | pages = 81–90 | date = Jun 2004 | pmid = 15370539 | doi = 10.1080/13816810490514270 }}
  • {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
  • {{cite journal | vauthors = Sirchia R, Luparello C | title = Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells | journal = Biological Chemistry | volume = 388 | issue = 5 | pages = 457–65 | date = May 2007 | pmid = 17516841 | doi = 10.1515/BC.2007.059 }}
{{refend}}

External links

  • {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3064 | title = Frizzled Receptors: FZD6 | accessdate = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
{{NLM content}}{{G protein-coupled receptors|g4}}

1 : G protein-coupled receptors
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