| 释义 |
- Interactions
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- Further reading
- External links
{{Infobox_gene}}Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.[1][2][3]This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It was originally reported to bind specifically to the Ras-GTPase-activating protein by associating with its SH3 domain, but this interaction has recently been challenged.[4] Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[3] G3BP1 can initiate stress granule formation and labeled G3BP1 is commonly used as a marker for stress granules[5]. InteractionsG3BP1 has been shown to interact with USP10.[6] It also interacts with SND1[5]. References1. ^{{cite journal |vauthors=Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B | title = A Ras-GTPase-activating protein SH3-domain-binding protein | journal = Mol Cell Biol | volume = 16 | issue = 6 | pages = 2561–9 |date=Jul 1996 | pmid = 8649363 | pmc = 231246 | doi = 10.1128/MCB.16.6.2561}}
2. ^{{cite journal |vauthors=Costa M, Ochem A, Staub A, Falaschi A | title = Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway | journal = Nucleic Acids Res | volume = 27 | issue = 3 | pages = 817–21 |date=Mar 1999 | pmid = 9889278 | pmc = 148252 | doi =10.1093/nar/27.3.817 }}
3. ^1 {{cite web | title = Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10146| accessdate = }}
4. ^{{Cite journal | pmid = 22205990| pmc = 3242762| year = 2011| author1 = Annibaldi| first1 = A| title = Revisiting G3BP1 as a RasGAP binding protein: Sensitization of tumor cells to chemotherapy by the RasGAP 317-326 sequence does not involve G3BP1| journal = PLoS ONE| volume = 6| issue = 12| pages = e29024| last2 = Dousse| first2 = A| last3 = Martin| first3 = S| last4 = Tazi| first4 = J| last5 = Widmann| first5 = C| doi = 10.1371/journal.pone.0029024| bibcode = 2011PLoSO...629024A}}
5. ^{{Cite journal|last=Mahboubi|first=Hicham|last2=Stochaj|first2=Ursula|date=2017-04-01|title=Cytoplasmic stress granules: Dynamic modulators of cell signaling and disease|journal=Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease|volume=1863|issue=4|pages=884–895|doi=10.1016/j.bbadis.2016.12.022|pmid=28095315|issn=0925-4439}}
6. ^{{cite journal |last=Soncini |first=C |authorlink= |author2=Berdo I|author3=Draetta G |date=Jun 2001 |title=Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease |journal=Oncogene |volume=20 |issue=29 |pages=3869–79 |publisher= |location = England| issn = 0950-9232| pmid = 11439350 |doi = 10.1038/sj.onc.1204553 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
[5]Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532. Further reading{{refbegin | 2}}- {{cite journal |vauthors=Irvine K, Stirling R, Hume D, Kennedy D |title=Rasputin, more promiscuous than ever: a review of G3BP |journal=Int. J. Dev. Biol. |volume=48 |issue= 10 |pages= 1065–77 |year= 2005 |pmid= 15602692 |doi= 10.1387/ijdb.041893ki }}
- {{cite journal |vauthors=Onno M, Nakamura T, Hillova J, Hill M |title=Rearrangement of the human tre oncogene by homologous recombination between Alu repeats of nucleotide sequences from two different chromosomes |journal=Oncogene |volume=7 |issue= 12 |pages= 2519–23 |year= 1993 |pmid= 1461655 |doi= }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
- {{cite journal |vauthors=Gallouzi IE, Parker F, Chebli K |title=A Novel Phosphorylation-Dependent RNase Activity of GAP-SH3 Binding Protein: a Potential Link between Signal Transduction and RNA Stability |journal=Mol. Cell. Biol. |volume=18 |issue= 7 |pages= 3956–65 |year= 1998 |pmid= 9632780 |doi= 10.1128/MCB.18.7.3956| pmc=108980 |display-authors=etal}}
- {{cite journal |vauthors=Kociok N, Esser P, Unfried K |title=Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells |journal=J. Cell. Biochem. |volume=74 |issue= 2 |pages= 194–201 |year= 1999 |pmid= 10404389 |doi=10.1002/(SICI)1097-4644(19990801)74:2<194::AID-JCB5>3.0.CO;2-M |display-authors=etal}}
- {{cite journal |vauthors=Soncini C, Berdo I, Draetta G |title=Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease |journal=Oncogene |volume=20 |issue= 29 |pages= 3869–79 |year= 2001 |pmid= 11439350 |doi= 10.1038/sj.onc.1204553 }}
- {{cite journal |vauthors=Tourrière H, Gallouzi IE, Chebli K |title=RasGAP-Associated Endoribonuclease G3BP: Selective RNA Degradation and Phosphorylation-Dependent Localization |journal=Mol. Cell. Biol. |volume=21 |issue= 22 |pages= 7747–60 |year= 2001 |pmid= 11604510 |doi= 10.1128/MCB.21.22.7747-7760.2001 | pmc=99945 |display-authors=etal}}
- {{cite journal |vauthors=Barnes CJ, Li F, Mandal M |title=Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors |journal=Cancer Res. |volume=62 |issue= 5 |pages= 1251–5 |year= 2002 |pmid= 11888885 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
- {{cite journal |vauthors=Tourrière H, Chebli K, Zekri L |title=The RasGAP-associated endoribonuclease G3BP assembles stress granules |journal=J. Cell Biol. |volume=160 |issue= 6 |pages= 823–31 |year= 2003 |pmid= 12642610 |doi= 10.1083/jcb.200212128 | pmc=2173781 |display-authors=etal}}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
- {{cite journal |vauthors=Brill LM, Salomon AR, Ficarro SB |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d |display-authors=etal}}
- {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |display-authors=etal|bibcode=2004PNAS..10112130B }}
- {{cite journal |vauthors=Katsafanas GC, Moss B |title=Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein (G3BP) and cytoplasmic activation/proliferation-associated protein (p137) individually or as a heterodimer |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52210–7 |year= 2005 |pmid= 15471883 |doi= 10.1074/jbc.M411033200 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
- {{cite journal |vauthors=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119–26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
{{refend}}External links- {{UCSC genome browser|G3BP1}}
- {{UCSC gene details|G3BP1}}
{{gene-5-stub}} |