“Galactosyldiacylglycerol alpha-2,3-sialyltransferase”的意思、由来-开放百科全书

词条

Galactosyldiacylglycerol alpha-2,3-sialyltransferase

释义

References

{{enzyme
| Name = galactosyldiacylglycerol alpha-2,3-sialyltransferase
| EC_number = 2.4.99.5
| CAS_number = 80237-98-5
| IUBMB_EC_number = 2/4/99/5
| GO_code = 0047289
| image =
| width =
| caption =
}}

In enzymology, a galactosyldiacylglycerol alpha-2,3-sialyltransferase ({{EC number|2.4.99.5}}) is an enzyme that catalyzes the chemical reaction

CMP-N-acetylneuraminate + 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol CMP + 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn- glycerol

Thus, the two substrates of this enzyme are CMP-N-acetylneuraminate and 1,2-diacyl-3-beta-D-galactosyl-sn-glycerol, whereas its 3 products are CMP, 1,2-diacyl-3-[3-(alpha-D-N-acetylneuraminyl)-beta-D-galactosyl]-sn-, and glycerol.

This enzyme belongs to the family of transferases, specifically those glycosyltransferases that do not transfer hexosyl or pentosyl groups. The systematic name of this enzyme class is CMP-N-acetylneuraminate:1,2-diacyl-3-beta-D-galactosyl-sn-glycerol N-acetylneuraminyltransferase. This enzyme participates in glycerolipid metabolism.

References

{{cite journal |vauthors=Pieringer J, Keech S, Pieringer RA | date = 1981 | title = Biosynthesis in vitro of sialosylgalactosyldiacylglycerol by mouse brain microsomes | journal = J. Biol. Chem. | volume = 256 | pages = 12306–9 | pmid = 7298658 | issue = 23 }}
{{cite journal |vauthors=Weinstein J, de Souza-e-Silva U, Paulson JC | date = 1982 | title = Purification of a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase and a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase to homogeneity from rat liver | journal = J. Biol. Chem. | volume = 257 | pages = 13835–44 | pmid = 7142179 | issue = 22 }}
{{cite journal |vauthors=Weinstein J, de Souza-e-Silva U, Paulson JC | date = 1982 | title = Sialylation of glycoprotein oligosaccharides N-linked to asparagine Enzymatic characterization of a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase and a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase from rat liver | journal = J. Biol. Chem. | volume = 257 | pages = 13845–53 | pmid = 7142180 | issue = 22 }}

2 : EC 2.4.99|Enzymes of unknown structure

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