“Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase”的意思、由来-开放百科全书

词条

Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

释义

Structural studies
References

{{enzyme
| Name = galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
| EC_number = 2.4.1.135
| CAS_number = 9030-08-4
| IUBMB_EC_number = 2/4/1/135
| GO_code = 0015018
| image =
| width =
| caption =
}}

In enzymology, a galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase ({{EC number|2.4.1.135}}) is an enzyme that catalyzes the chemical reaction

UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O- beta-D-xylosylprotein

Thus, the two substrates of this enzyme are UDP-glucuronate and 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein, whereas its 3 products are UDP, 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-, and beta-D-xylosylprotein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xyl osyl-protein D-glucuronosyltransferase. Other names in common use include glucuronosyltransferase I, and uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1V82}}, {{PDB link|1V83}}, {{PDB link|1V84}}, and {{PDB link|2D0J}}.

References

{{cite journal |vauthors=Helting T, Roden L | date = 1969 | title = Biosynthesis of chondroitin sulfate. II. Glucuronosyl transfer in the formation of the carbohydrate-protein linkage region | journal = J. Biol. Chem. | volume = 244 | pages = 2799–805 | pmid = 5770003 | issue = 10 }}
{{cite journal | author = Helting T | date = 1972 | title = Biosynthesis of heparin. Solubilization and partial purification of uridine diphosphate glucuronic acid: acceptor glucuronosyltransferase from mouse mastocytoma | journal = J. Biol. Chem. | volume = 247 | pages = 4327–32 | pmid = 4260846 | issue = 13 }}
{{cite journal | author = T, Sugahara K | date = 1998 | title = Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans | journal = J. Biol. Chem. | volume = 273 | pages = 6615–8 | pmid = 9506957 | doi = 10.1074/jbc.273.12.6615 | last2 = Tone | first2 = Y | last3 = Tamura | first3 = J | last4 = Neumann | first4 = KW | last5 = Ogawa | first5 = T | last6 = Oka | first6 = S | last7 = Kawasaki | first7 = T | last8 = Sugahara | first8 = K | issue = 12 }}

3 : EC 2.4.1|Manganese enzymes|Enzymes of known structure

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