| 释义 |
- Function
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.[1] Function The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts[1] See also References 1. ^1 {{cite web | title = Entrez Gene: GALR3 galanin receptor 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8484| accessdate = }}
Further reading {{refbegin|33em}}- {{cite journal | vauthors = Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao WJ, Vaysse PJ, Branchek TA, Gerald C, Jones KA | title = Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels | journal = The Journal of Biological Chemistry | volume = 273 | issue = 36 | pages = 23321–6 | date = Sep 1998 | pmid = 9722565 | doi = 10.1074/jbc.273.36.23321 }}
- {{cite journal | vauthors = Kolakowski LF, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF | title = Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3 | journal = Journal of Neurochemistry | volume = 71 | issue = 6 | pages = 2239–51 | date = Dec 1998 | pmid = 9832121 | doi = 10.1046/j.1471-4159.1998.71062239.x }}
- {{cite journal | vauthors = Iismaa TP, Fathi Z, Hort YJ, Iben LG, Dutton JL, Baker E, Sutherland GR, Shine J | title = Structural organization and chromosomal localization of three human galanin receptor genes | journal = Annals of the New York Academy of Sciences | volume = 863 | issue = | pages = 56–63 | date = Dec 1998 | pmid = 9928159 | doi = 10.1111/j.1749-6632.1998.tb10683.x }}
- {{cite journal | vauthors = Lapsys NM, Furler SM, Henderson NK, Dutton JL, Hort YJ, Eisman JA, Shine J, Iismaa TP | title = A polymorphism in the human GALR3 galanin receptor gene (GALNR3) | journal = Molecular and Cellular Probes | volume = 13 | issue = 4 | pages = 325–7 | date = Aug 1999 | pmid = 10441207 | doi = 10.1006/mcpr.1999.0254 }}
- {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22 | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | date = Dec 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
- {{cite journal | vauthors = Berger A, Tuechler C, Almer D, Kogner P, Ratschek M, Kerbl R, Iismaa TP, Jones N, Sperl W, Kofler B | title = Elevated expression of galanin receptors in childhood neuroblastic tumors | journal = Neuroendocrinology | volume = 75 | issue = 2 | pages = 130–8 | date = Feb 2002 | pmid = 11867941 | doi = 10.1159/000048229 }}
- {{cite journal | vauthors = Belfer I, Hipp H, Bollettino A, McKnight C, Evans C, Virkkunen M, Albaugh B, Max MB, Goldman D, Enoch MA | title = Alcoholism is associated with GALR3 but not two other galanin receptor genes | journal = Genes, Brain, and Behavior | volume = 6 | issue = 5 | pages = 473–81 | date = Jul 2007 | pmid = 17083333 | doi = 10.1111/j.1601-183X.2006.00275.x }}
- {{cite journal | vauthors = Runesson J, Sollenberg UE, Jurkowski W, Yazdi S, Eriksson EE, Elofsson A, Langel U | title = Determining receptor-ligand interaction of human galanin receptor type 3 | journal = Neurochemistry International | volume = 57 | issue = 7 | pages = 804–11 | date = Dec 2010 | pmid = 20817064 | doi = 10.1016/j.neuint.2010.08.018 | url = http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-37226 }}
{{refend}} External links - {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2983 | title = Galanin Receptors: GAL3 | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
{{transmembranereceptor-stub}}{{NLM content}}{{G protein-coupled receptors|g1}}{{Neuropeptidergics}} 1 : G protein-coupled receptors |