| 释义 |
- References
- Further reading
{{Underlinked|date=March 2014}}{{Infobox_gene}}Galectin-2 is a protein that in humans is encoded by the LGALS2 gene.[1][2][3]The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.[3] References1. ^{{cite journal |vauthors=Gitt MA, Barondes SH | title = Genomic sequence and organization of two members of a human lectin gene family | journal = Biochemistry | volume = 30 | issue = 1 | pages = 82–9 |date=Feb 1991 | pmid = 1988031 | pmc = | doi =10.1021/bi00215a013 }}
2. ^{{cite journal |vauthors=Sturm A, Lensch M, Andre S, Kaltner H, Wiedenmann B, Rosewicz S, Dignass AU, Gabius HJ | title = Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation | journal = J Immunol | volume = 173 | issue = 6 | pages = 3825–37 |date=Sep 2004 | pmid = 15356130 | pmc = | doi = 10.4049/jimmunol.173.6.3825}}
3. ^1 {{cite web | title = Entrez Gene: LGALS2 lectin, galactoside-binding, soluble, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3957| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Gitt MA, Massa SM, Leffler H, Barondes SH |title=Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10601–6 |year= 1992 |pmid= 1375225 |doi= }}
- {{cite journal |vauthors=Gitt MA, Barondes SH |title=Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 20 |pages= 7603–7 |year= 1986 |pmid= 3020551 |doi=10.1073/pnas.83.20.7603 | pmc=386769 }}
- {{cite journal |vauthors=Lobsanov YD, Gitt MA, Leffler H, etal |title=X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution. |journal=J. Biol. Chem. |volume=268 |issue= 36 |pages= 27034–8 |year= 1994 |pmid= 8262940 |doi= }}
- {{cite journal |vauthors=Lobsanov YD, Gitt MA, Leffler H, etal |title=Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II). |journal=J. Mol. Biol. |volume=233 |issue= 3 |pages= 553–5 |year= 1993 |pmid= 8411163 |doi= 10.1006/jmbi.1993.1533 }}
- {{cite journal |vauthors=Mehrabian M, Gitt MA, Sparkes RS, etal |title=Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13. |journal=Genomics |volume=15 |issue= 2 |pages= 418–20 |year= 1993 |pmid= 8449510 |doi= 10.1006/geno.1993.1078 }}
- {{cite journal |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ozaki K, Inoue K, Sato H, etal |title=Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. |journal=Nature |volume=429 |issue= 6987 |pages= 72–5 |year= 2004 |pmid= 15129282 |doi= 10.1038/nature02502 }}
- {{cite journal |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Christensen MB, Lawlor DA, Gaunt TR, etal |title=Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study. |journal=Diabetologia |volume=49 |issue= 4 |pages= 673–7 |year= 2006 |pmid= 16468038 |doi= 10.1007/s00125-006-0145-3 }}
- {{cite journal |vauthors=Stowell SR, Karmakar S, Stowell CJ, etal |title=Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells. |journal=Blood |volume=109 |issue= 1 |pages= 219–27 |year= 2007 |pmid= 16940423 |doi= 10.1182/blood-2006-03-007153 | pmc=1785076 }}
- {{cite journal |vauthors=Mangino M, Braund P, Singh R, etal |title=LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians. |journal=Atherosclerosis |volume=194 |issue= 1 |pages= 112–5 |year= 2007 |pmid= 17098239 |doi= 10.1016/j.atherosclerosis.2006.10.004 }}
- {{cite journal |vauthors=Kimura A, Takahashi M, Choi BY, etal |title=Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations. |journal=Tissue Antigens |volume=69 |issue= 3 |pages= 265–9 |year= 2007 |pmid= 17493152 |doi= 10.1111/j.1399-0039.2006.00798.x }}
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