| 词条 | Galmic |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 381105630 | IUPAC_name = | image = Galmic_structure.png | width = 300 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 11636593 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 578918 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 25046661 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C51H60N10O11/c1-26-36-41(64)61-51(6,45(68)55-38-32-21-13-11-19-30(32)31-20-12-14-22-33(31)38)48-58-37(28(3)72-48)40(63)60-50(5,44(67)54-34(42(65)69-7)23-15-16-24-52)47-57-35(27(2)71-47)39(62)59-49(4,46(56-36)70-26)43(66)53-25-29-17-9-8-10-18-29/h11-14,19-22,29,34,38H,8-10,15-18,23-25,52H2,1-7H3,(H,53,66)(H,54,67)(H,55,68)(H,59,62)(H,60,63)(H,61,64)/t34-,49-,50-,51-/m0/s1 | C=51 | H=60 | N=10 | O=11 | molecular_weight = 989.080 | smiles = c7cccc3c7-c4ccccc4C3NC(=O)C(C)(c(oc6C)nc6C(=O)NC2(C)C(=O)NC(C(=O)OC)CCCCN)NC(=O)c1nc(oc1C)C(C)(NC(=O)c5nc2oc5C)C(=O)NCC8CCCCC8 }}Galmic is a drug which acts as a selective, non-peptide agonist at the galanin receptors GALR.[1] It has anticonvulsant, antidepressant and analgesic effects in animal studies,[2] but also inhibits memory functions.[3] References1. ^{{cite journal |vauthors=Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J |title=Synthesis of galmic: a nonpeptide galanin receptor agonist |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=101 |issue=48 |pages=16727–32 |date=November 2004 |pmid=15557002 |pmc=534730 |doi=10.1073/pnas.0407543101 |url=}} {{Neuropeptide agonists and antagonists}}{{anticonvulsant-stub}}{{analgesic-stub}}2. ^{{cite journal |vauthors=Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J |title=Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests |journal=Proceedings of the National Academy of Sciences of the United States of America |volume=101 |issue=28 |pages=10470–5 |date=July 2004 |pmid=15240875 |pmc=478593 |doi=10.1073/pnas.0403802101 |url=}} 3. ^{{cite journal |vauthors=Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T |title=Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice |journal=Neuropeptides |volume=39 |issue=3 |pages=249–51 |date=June 2005 |pmid=15944018 |doi=10.1016/j.npep.2004.12.010 |url=}} 1 : Neuropeptides |
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