“Gamma-glutamyl-gamma-aminobutyrate hydrolase”的意思、由来-开放百科全书

词条

Gamma-glutamyl-gamma-aminobutyrate hydrolase

释义

References

{{enzyme
| Name = Gamma-glutamyl-gamma-aminobutyrate hydrolase
| EC_number = 3.5.1.94
| CAS_number =
| IUBMB_EC_number = 3/5/1/94
| GO_code = 0033969
| image =
| width =
| caption =
}}

In enzymology, a gamma-glutamyl-gamma-aminobutyrate hydrolase ({{EC number|3.5.1.94}}) is an enzyme that catalyzes the chemical reaction

4-(gamma-glutamylamino)butanoate + H₂O 4-aminobutanoate + L-glutamate

Thus, the two substrates of this enzyme are 4-(gamma-glutamylamino)butanoate and H₂O, whereas its two products are 4-aminobutanoate and L-glutamate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 4-(gamma-glutamylamino)butanoate amidohydrolase. Other names in common use include gamma-glutamyl-GABA hydrolase, PuuD, and YcjL. This enzyme participates in urea cycle and metabolism of amino groups.

References

{{cite journal |vauthors=Kurihara S, Oda S, Kato K, Kim HG, Koyanagi T, Kumagai H, Suzuki H | date = 2005 | title = A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12 | journal = J. Biol. Chem. | volume = 280 | pages = 4602–8 | pmid = 15590624 | doi = 10.1074/jbc.M411114200 | issue = 6 }}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.1|Enzymes of unknown structure

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