| 释义 |
- Function
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Gamma-glutamyltransferase 1 (GGT1), also known as CD224 (Cluster of Differentiation 224), is a human gene.[1] Function Human gamma-glutamyltransferase catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This heteroduplex enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized. This gene encodes several transcript variants; studies suggest that many transcripts of this gene family may be non-functional or represent pseudogenes. The functional transcripts which have been fully characterized have been grouped and classified as type I gamma-glutamyltransferase. Complex splicing events may take place in a tissue-specific manner, resulting in marked dissimilarity in the 5' UTRs. Several 5' UTR transcript variants of the type I gene have been identified in different tissues and cancer cells.[1] See also - Cluster of differentiation
References 1. ^1 {{cite web | title = Entrez Gene: GGT1 gamma-glutamyltransferase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2678| access-date = }}
Further reading {{refbegin|2}}- {{cite journal | vauthors = Chikhi N, Holic N, Guellaen G, Laperche Y | title = Gamma-glutamyl transpeptidase gene organization and expression: a comparative analysis in rat, mouse, pig and human species | journal = Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology | volume = 122 | issue = 4 | pages = 367–80 | date = April 1999 | pmid = 10392451 | doi = 10.1016/S0305-0491(99)00013-9 }}
- {{cite journal | vauthors = Indirani N, Hill PG | title = Partial purification and some properties of gamma-glutamyl transpeptidase from human bile | journal = Biochimica et Biophysica Acta | volume = 483 | issue = 1 | pages = 57–62 | date = July 1977 | pmid = 18198 | doi = 10.1016/0005-2744(77)90007-9 }}
- {{cite journal | vauthors = Tate SS, Ross ME | title = Human kidney gamma-glutamyl transpeptidase. Catalytic properties, subunit structure, and localization of the gamma-glutamyl binding site on the light subunit | journal = The Journal of Biological Chemistry | volume = 252 | issue = 17 | pages = 6042–5 | date = September 1977 | pmid = 19463 | doi = }}
- {{cite journal | vauthors = Welbourne TC | title = Cytoplasmic gamma-glutamyltransferase: isolation, product formation and physiological role | journal = Current Problems in Clinical Biochemistry | volume = 8 | issue = | pages = 201–15 | year = 1978 | pmid = 28899 | doi = }}
- {{cite journal | vauthors = Courtay C, Oster T, Michelet F, Visvikis A, Diederich M, Wellman M, Siest G | title = Gamma-glutamyltransferase: nucleotide sequence of the human pancreatic cDNA. Evidence for a ubiquitous gamma-glutamyltransferase polypeptide in human tissues | journal = Biochemical Pharmacology | volume = 43 | issue = 12 | pages = 2527–33 | date = June 1992 | pmid = 1378736 | doi = 10.1016/0006-2952(92)90140-E }}
- {{cite journal | vauthors = Pawlak A, Cohen EH, Octave JN, Schweickhardt R, Wu SJ, Bulle F, Chikhi N, Baik JH, Siegrist S, Guellaën G | title = An alternatively processed mRNA specific for gamma-glutamyl transpeptidase in human tissues | journal = The Journal of Biological Chemistry | volume = 265 | issue = 6 | pages = 3256–62 | date = February 1990 | pmid = 1968061 | doi = }}
- {{cite journal | vauthors = Pitot HC, Goodspeed D, Dunn T, Hendrich S, Maronpot RR, Moran S | title = Regulation of the expression of some genes for enzymes of glutathione metabolism in hepatotoxicity and hepatocarcinogenesis | journal = Toxicology and Applied Pharmacology | volume = 97 | issue = 1 | pages = 23–34 | date = January 1989 | pmid = 2563599 | doi = 10.1016/0041-008X(89)90052-5 }}
- {{cite journal | vauthors = Goodspeed DC, Dunn TJ, Miller CD, Pitot HC | title = Human gamma-glutamyl transpeptidase cDNA: comparison of hepatoma and kidney mRNA in the human and rat | journal = Gene | volume = 76 | issue = 1 | pages = 1–9 | date = March 1989 | pmid = 2568315 | doi = 10.1016/0378-1119(89)90002-4 }}
- {{cite journal | vauthors = Pawlak A, Wu SJ, Bulle F, Suzuki A, Chikhi N, Ferry N, Baik JH, Siegrist S, Guellaën G | title = Different gamma-glutamyl transpeptidase mRNAs are expressed in human liver and kidney | journal = Biochemical and Biophysical Research Communications | volume = 164 | issue = 2 | pages = 912–8 | date = October 1989 | pmid = 2573352 | doi = 10.1016/0006-291X(89)91545-3 }}
- {{cite journal | vauthors = Laperche Y, Bulle F, Aissani T, Chobert MN, Aggerbeck M, Hanoune J, Guellaën G | title = Molecular cloning and nucleotide sequence of rat kidney gamma-glutamyl transpeptidase cDNA | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 83 | issue = 4 | pages = 937–41 | date = February 1986 | pmid = 2869484 | pmc = 322985 | doi = 10.1073/pnas.83.4.937 }}
- {{cite journal | vauthors = Bulle F, Mattei MG, Siegrist S, Pawlak A, Passage E, Chobert MN, Laperche Y, Guellaën G | title = Assignment of the human gamma-glutamyl transferase gene to the long arm of chromosome 22 | journal = Human Genetics | volume = 76 | issue = 3 | pages = 283–6 | date = July 1987 | pmid = 2885259 | doi = 10.1007/BF00283624 }}
- {{cite journal | vauthors = Tate SS, Khadse V, Wellner D | title = Renal gamma-glutamyl transpeptidases: structural and immunological studies | journal = Archives of Biochemistry and Biophysics | volume = 262 | issue = 2 | pages = 397–408 | date = May 1988 | pmid = 2896486 | doi = 10.1016/0003-9861(88)90390-6 }}
- {{cite journal | vauthors = Tate SS, Galbraith RA | title = In vitro translation and processing of human hepatoma cell (Hep G2) gamma-glutamyl transpeptidase | journal = Biochemical and Biophysical Research Communications | volume = 154 | issue = 3 | pages = 1167–73 | date = August 1988 | pmid = 2900635 | doi = 10.1016/0006-291X(88)90263-X }}
- {{cite journal | vauthors = Rajpert-De Meyts E, Heisterkamp N, Groffen J | title = Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 23 | pages = 8840–4 | date = December 1988 | pmid = 2904146 | pmc = 282602 | doi = 10.1073/pnas.85.23.8840 }}
- {{cite journal | vauthors = Sakamuro D, Yamazoe M, Matsuda Y, Kangawa K, Taniguchi N, Matsuo H, Yoshikawa H, Ogasawara N | title = The primary structure of human gamma-glutamyl transpeptidase | journal = Gene | volume = 73 | issue = 1 | pages = 1–9 | date = December 1988 | pmid = 2907498 | doi = 10.1016/0378-1119(88)90307-1 }}
- {{cite journal | vauthors = Ikeda Y, Fujii J, Anderson ME, Taniguchi N, Meister A | title = Involvement of Ser-451 and Ser-452 in the catalysis of human gamma-glutamyl transpeptidase | journal = The Journal of Biological Chemistry | volume = 270 | issue = 38 | pages = 22223–8 | date = September 1995 | pmid = 7673200 | doi = 10.1074/jbc.270.38.22223 }}
- {{cite journal | vauthors = Wetmore LA, Gerard C, Drazen JM | title = Human lung expresses unique gamma-glutamyl transpeptidase transcripts | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 16 | pages = 7461–5 | date = August 1993 | pmid = 7689219 | pmc = 47161 | doi = 10.1073/pnas.90.16.7461 }}
- {{cite journal | vauthors = Ikeda Y, Fujii J, Taniguchi N, Meister A | title = Human gamma-glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit | journal = The Journal of Biological Chemistry | volume = 270 | issue = 21 | pages = 12471–5 | date = May 1995 | pmid = 7759490 | doi = 10.1074/jbc.270.21.12471 }}
- {{cite journal | vauthors = Courtay C, Heisterkamp N, Siest G, Groffen J | title = Expression of multiple gamma-glutamyltransferase genes in man | journal = The Biochemical Journal | volume = 297 | issue = Pt 3 | pages = 503–8 | date = February 1994 | pmid = 7906515 | pmc = 1137862 | doi = }}
- {{cite journal | vauthors = Ikeda Y, Fujii J, Taniguchi N | title = Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis | journal = The Journal of Biological Chemistry | volume = 268 | issue = 6 | pages = 3980–5 | date = February 1993 | pmid = 8095045 | doi = }}
{{refend}} External links - {{MeshName| GGT1 +protein,+human}}
{{NLM content}}{{Clusters of differentiation}}{{membrane-protein-stub}} 1 : Clusters of differentiation |