“Ganglioside galactosyltransferase”的意思、由来-开放百科全书

词条

Ganglioside galactosyltransferase

释义

References

{{enzyme
| Name = ganglioside galactosyltransferase
| EC_number = 2.4.1.62
| CAS_number = 37217-28-0
| IUBMB_EC_number = 2/4/1/62
| GO_code = 0047915
| image =
| width =
| caption =
}}

In enzymology, a ganglioside galactosyltransferase ({{EC number|2.4.1.62}}) is an enzyme that catalyzes the chemical reaction

UDP-galactose + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine UDP + D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine

The 2 substrates of this enzyme are UDP-galactose and N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-1,4-beta-D-glucosyl-N-acylsphingosine, whereas its 2 products are UDP and D-galactosyl-1,3-beta-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galac tosyl-D-glucosyl-N-acylsphingosine beta-1,3-D-galactosyltransferase. Other names in common use include UDP-galactose-ceramide galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl), galactosyl-glucosyl-ceramide galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, and GM1-synthase. This enzyme participates in glycosphingolipid biosynthesis - ganglioseries and glycan structures - biosynthesis 2.

References

{{cite journal |vauthors=Basu S, Kaufman B, Roseman S | date = 1965 | title = Conversion of Tay–Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid galactosyltransferase | journal = J. Biol. Chem. | volume = 240 | pages = 4115–7 | pmid = 5842076 | issue = 10 }}
{{cite journal |vauthors=Yip GB, Dain JA | date = 1970 | title = The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)galactosyl-glucosyl-ceram ide galactosyltransferase in rat brain | journal = Biochim. Biophys. Acta | volume = 206 | pages = 252–60 | pmid = 4987145 | issue = 2 | doi=10.1016/0005-2744(70)90108-7}}
{{cite journal |vauthors=Yip MC, Dain JA | date = 1970 | title = Frog brain uridine diphosphate galactose-N-acetylgalactosaminyl-N-acetylneuraminylgalactosylglucosy lceram ide galactosyltransferase | journal = Biochem. J. | volume = 118 | pages = 247–52 | pmid = 5484669 | issue = 2 | pmc = 1179110 }}

2 : EC 2.4.1|Enzymes of unknown structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。