| 释义 |
- References
- Further reading
- External links
{{Infobox_gene}}Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene.[1][2][3]Glucosidase I is the first enzyme in the N-linked oligosaccharide processing pathway. GCS1 cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. GCS1 is located in the lumen of the endoplasmic reticulum.[3] GCS1 may also refer to "generative cell specific 1", also called HAP2 (hapless2), a gene of lower eukaryotes which is thought to be responsible for gametes fusion .[4] . References1. ^{{cite journal |vauthors=Kalz-Fuller B, Bieberich E, Bause E | title = Sexualization and expression of glucosidase I from human hippocampus | journal = Eur J Biochem | volume = 231 | issue = 2 | pages = 344–51 |date=Sep 1995 | pmid = 7635146 | pmc = | doi =10.1111/j.1432-1033.1995.tb20706.x }}
2. ^{{cite journal |vauthors=Kalz-Fuller B, Heidrich-Kaul C, Nothen M, Bause E, Schwanitz G | title = Localization of the human glucosidase I gene to chromosome 2p12-p13 by fluorescence in situ hybridization and PCR analysis of somatic cell hybrids | journal = Genomics | volume = 34 | issue = 3 | pages = 442–3 |date=Sep 1996 | pmid = 8786151 | pmc = | doi = 10.1006/geno.1996.0313 }}
3. ^1 {{cite web | title = Entrez Gene: GCS1 glucosidase I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7841| accessdate = }}
4. ^{{cite web | title = Gamete Fusion: Key Protein Identified | url = http://www.cell.com/current-biology/abstract/S0960-9822(08)00604-0| accessdate = 06.05.09}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Feizi T, Larkin M |title=AIDS and glycosylation |journal=Glycobiology |volume=1 |issue= 1 |pages= 17–23 |year= 1992 |pmid= 2136376 |doi=10.1093/glycob/1.1.17 }}
- {{cite journal |vauthors=Land A, Braakman I |title=Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum |journal=Biochimie |volume=83 |issue= 8 |pages= 783–90 |year= 2001 |pmid= 11530211 |doi=10.1016/S0300-9084(01)01314-1 }}
- {{cite journal |vauthors=Fenouillet E, Gluckman JC |title=Effect of a glucosidase inhibitor on the bioactivity and immunoreactivity of human immunodeficiency virus type 1 envelope glycoprotein |journal=J. Gen. Virol. |volume=72 ( Pt 8) |issue= 8|pages= 1919–26 |year= 1991 |pmid= 1678778 |doi=10.1099/0022-1317-72-8-1919 }}
- {{cite journal |vauthors=Ratner L, vander Heyden N, Dedera D |title=Inhibition of HIV and SIV infectivity by blockade of alpha-glucosidase activity |journal=Virology |volume=181 |issue= 1 |pages= 180–92 |year= 1991 |pmid= 1704656 |doi=10.1016/0042-6822(91)90483-R }}
- {{cite journal |vauthors=Dedera DA, Gu RL, Ratner L |title=Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function |journal=Virology |volume=187 |issue= 1 |pages= 377–82 |year= 1992 |pmid= 1736542 |doi=10.1016/0042-6822(92)90331-I }}
- {{cite journal |vauthors=Murphy CI, Lennick M, Lehar SM |title=Temporal expression of HIV-1 envelope proteins in baculovirus-infected insect cells: implications for glycosylation and CD4 binding |journal=Genet. Anal. Tech. Appl. |volume=7 |issue= 6 |pages= 160–71 |year= 1991 |pmid= 2076345 |doi=10.1016/0735-0651(90)90030-J |display-authors=etal}}
- {{cite journal |vauthors=Kalyanaraman VS, Rodriguez V, Veronese F |title=Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1 |journal=AIDS Res. Hum. Retroviruses |volume=6 |issue= 3 |pages= 371–80 |year= 1990 |pmid= 2187500 |doi=10.1089/aid.1990.6.371 |display-authors=etal}}
- {{cite journal |vauthors=Shimizu H, Tsuchie H, Honma H |title=Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins |journal=Jpn. J. Med. Sci. Biol. |volume=43 |issue= 3 |pages= 75–87 |year= 1991 |pmid= 2283726 |doi= 10.7883/yoken1952.43.75|display-authors=etal}}
- {{cite journal |vauthors=Leonard CK, Spellman MW, Riddle L |title=Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells |journal=J. Biol. Chem. |volume=265 |issue= 18 |pages= 10373–82 |year= 1990 |pmid= 2355006 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Pal R, Hoke GM, Sarngadharan MG |title=Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 9 |pages= 3384–8 |year= 1989 |pmid= 2541446 |doi=10.1073/pnas.86.9.3384 | pmc=287137 }}
- {{cite journal |vauthors=Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP |title=Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport |journal=J. Virol. |volume=63 |issue= 6 |pages= 2452–6 |year= 1989 |pmid= 2542563 |doi= | pmc=250699 }}
- {{cite journal |vauthors=Kozarsky K, Penman M, Basiripour L |title=Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein |journal=J. Acquir. Immune Defic. Syndr. |volume=2 |issue= 2 |pages= 163–9 |year= 1989 |pmid= 2649653 |doi= |display-authors=etal}}
- {{cite journal |vauthors=Walker BD, Kowalski M, Goh WC |title=Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 22 |pages= 8120–4 |year= 1987 |pmid= 2825177 |doi=10.1073/pnas.84.22.8120 | pmc=299490 |display-authors=etal}}
- {{cite journal |vauthors=Robinson WE, Montefiori DC, Mitchell WM |title=Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis |journal=AIDS Res. Hum. Retroviruses |volume=3 |issue= 3 |pages= 265–82 |year= 1988 |pmid= 2829950 |doi=10.1089/aid.1987.3.265 }}
- {{cite journal |vauthors=Gruters RA, Neefjes JJ, Tersmette M |title=Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase |journal=Nature |volume=330 |issue= 6143 |pages= 74–7 |year= 1987 |pmid= 2959866 |doi= 10.1038/330074a0 |display-authors=etal}}
- {{cite journal |vauthors=Blough HA, Pauwels R, De Clercq E |title=Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins |journal=Biochem. Biophys. Res. Commun. |volume=141 |issue= 1 |pages= 33–8 |year= 1987 |pmid= 3099781 |doi=10.1016/S0006-291X(86)80330-8 |display-authors=etal}}
- {{cite journal |vauthors=Montefiori DC, Robinson WE, Mitchell WM |title=Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 23 |pages= 9248–52 |year= 1988 |pmid= 3264072 |doi=10.1073/pnas.85.23.9248 | pmc=282716 }}
- {{cite journal |vauthors=Fenouillet E, Jones I, Powell B |title=Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain |journal=J. Virol. |volume=67 |issue= 1 |pages= 150–60 |year= 1993 |pmid= 8093218 |doi= | pmc=237347 |display-authors=etal}}
{{refend}}External links- [https://www.ncbi.nlm.nih.gov/books/NBK1332/ GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview]
{{Glycoprotein metabolism enzymes}}{{gene-2-stub}} |