| 词条 | Gefarnate |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 444167725 | IUPAC_name = (2E)-3,7-dimethylocta-2,6-dien-1-yl (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate | image = Gefarnate.svg | alt = Skeletal formula | width = 320 | image2 = Gefarnate-3D-spacefill.png | alt2 = Space-filling model | tradename = | Drugs.com = {{drugs.com|international|gefarnate}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 51-77-4 | ATC_prefix = A02 | ATC_suffix = BX07 | PubChem = 5282182 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2105085 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 1ISE2Y6ULA | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D01529 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4445377 | C=27 | H=44 | O=2 | molecular_weight = 400.637 g/mol | smiles = CC(C)=CCC/C(C)=C/CC/C(C)=C/CCC(=O)OC/C=C(C)/CCC=C(C)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C27H44O2/c1-22(2)12-8-14-24(5)16-10-17-25(6)18-11-19-27(28)29-21-20-26(7)15-9-13-23(3)4/h12-13,16,18,20H,8-11,14-15,17,19,21H2,1-7H3/b24-16+,25-18+,26-20+ | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = ZPACYDRSPFRDHO-ROBAGEODSA-N }}Gefarnate is a drug used for the treatment of gastric ulcers.[1] It also has been proposed for use in the treatment of dry eye syndrome.[2][3] References1. ^{{cite journal |vauthors=Ohta Y, Kobayashi T, Imai Y, Inui K, Yoshino J, Nakazawa S |title=Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone |journal=Biol. Pharm. Bull. |volume=28 |issue=8 |pages=1424–30 |date=August 2005 |pmid=16079487 |doi= 10.1248/bpb.28.1424|url=https://www.jstage.jst.go.jp/article/bpb/28/8/28_8_1424/_article}} {{Drugs for peptic ulcer and GORD}}{{alkene-stub}}{{gastrointestinal-drug-stub}}2. ^{{cite journal |vauthors=Peral A, Domínguez-Godínez CO, Carracedo G, Pintor J |title=Therapeutic targets in dry eye syndrome |journal=Drug News Perspect. |volume=21 |issue=3 |pages=166–76 |date=April 2008 |pmid=18560615 |doi= |url=}} 3. ^{{cite journal|vauthors=Gipson IK, Hori Y, Argüeso P |title=Character of ocular surface mucins and their alteration in dry eye disease |journal=Ocul Surf |volume=2 |issue=2 |pages=131–48 |date=April 2004 |pmid=17216084 |doi=10.1016/s1542-0124(12)70149-0 |url=http://www.theocularsurface.com/ArticlesV2N2-Gipson.htm }}{{dead link|date=January 2017 |bot=InternetArchiveBot |fix-attempted=yes }} 3 : Drugs acting on the gastrointestinal system and metabolism|Carboxylate esters|Polyolefins |
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