James Gregory may refer to:

• James Gregory (mathematician) (1638–1675), Scottish mathematician and astronomer
• James Gregory (physician) (1753–1821), Scottish physician
• James Gregory (mineralogist) (1832–1899), Scottish mineralogist
• James Gregory (actor) (1911–2002), American actor
• James Gregory (writer) (1941–2003), South African prison guard, author of Goodbye Bafana
• James Gregory (comedian) (born 1946), American comedian
• Jim Gregory (basketball), American former college basketball standout
• Jim Gregory (football chairman) (1928–1998), former English football club director and chairman
• Jim Gregory (ice hockey) (born 1935), former general manager and league executive in the National Hockey League
• James Crawford Gregory (1801–1832), Scottish physician
• James G. Gregory (1843–1932), Surgeon General of Connecticut and member of the Connecticut House of Representatives
• James Monroe Gregory (1849–1915), professor of Latin and dean at Howard University
• Jim Gregory (footballer) (1876–1949), Australian rules footballer

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