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词条 GFI1
释义

  1. Interactions

  2. References

  3. Further reading

  4. External links

{{Infobox_gene}}Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene.[1] It is important normal hematopoiesis.[2]

Interactions

GFI1 has been shown to interact with PIAS3[3] and RUNX1T1.[4]

References

1. ^{{cite journal | vauthors = Bell DW, Taguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Gilks CB, Zweidler-McKay P, Grimes HL, Tsichlis PN, Testa JR | title = Chromosomal localization of a gene, GF1, encoding a novel zinc finger protein reveals a new syntenic region between man and rodents | journal = Cytogenet Cell Genet | volume = 70 | issue = 3–4 | pages = 263–7 | date = July 1995 | pmid = 7789186 | pmc = | doi = 10.1159/000134048 }}
2. ^{{cite web | title = Entrez Gene: GFI1 growth factor independent 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2672| accessdate = }}
3. ^{{cite journal | vauthors = Rödel B, Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer HP, Möröy T | title = The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3 | journal = EMBO J. | volume = 19 | issue = 21 | pages = 5845–55 | date = November 2000 | pmid = 11060035 | pmc = 305799 | doi = 10.1093/emboj/19.21.5845 }}
4. ^{{cite journal | vauthors = McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S | title = Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism | journal = J. Cell. Biochem. | volume = 89 | issue = 5 | pages = 1005–18 | date = August 2003 | pmid = 12874834 | doi = 10.1002/jcb.10548 }}
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Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Gilks CB, Bear SE, Grimes HL, Tsichlis PN | title = Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein | journal = Mol. Cell. Biol. | volume = 13 | issue = 3 | pages = 1759–68 | year = 1993 | pmid = 8441411 | pmc = 359488 | doi = }}
  • {{cite journal | vauthors = Zweidler-Mckay PA, Grimes HL, Flubacher MM, Tsichlis PN | title = Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor | journal = Mol. Cell. Biol. | volume = 16 | issue = 8 | pages = 4024–34 | year = 1996 | pmid = 8754800 | pmc = 231398 | doi = }}
  • {{cite journal | vauthors = Roberts T, Cowell JK | title = Cloning of the human Gfi-1 gene and its mapping to chromosome region 1p22 | journal = Oncogene | volume = 14 | issue = 8 | pages = 1003–5 | year = 1997 | pmid = 9051000 | doi = 10.1038/sj.onc.1200910 }}
  • {{cite journal | vauthors = Rödel B, Tavassoli K, Karsunky H, Schmidt T, Bachmann M, Schaper F, Heinrich P, Shuai K, Elsässer HP, Möröy T | title = The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3 | journal = EMBO J. | volume = 19 | issue = 21 | pages = 5845–55 | year = 2000 | pmid = 11060035 | pmc = 305799 | doi = 10.1093/emboj/19.21.5845 }}
  • {{cite journal | vauthors = Osawa M, Yamaguchi T, Nakamura Y, Kaneko S, Onodera M, Sawada K, Jegalian A, Wu H, Nakauchi H, Iwama A | title = Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis | journal = Blood | volume = 100 | issue = 8 | pages = 2769–77 | year = 2002 | pmid = 12351384 | doi = 10.1182/blood-2002-01-0182 }}
  • {{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16899–903 | year = 2003 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}
  • {{cite journal | vauthors = Person RE, Li FQ, Duan Z, Benson KF, Wechsler J, Papadaki HA, Eliopoulos G, Kaufman C, Bertolone SJ, Nakamoto B, Papayannopoulou T, Grimes HL, Horwitz M | title = Mutations in proto-oncogene GFI1 cause human neutropenia and target ELA2 | journal = Nat. Genet. | volume = 34 | issue = 3 | pages = 308–12 | year = 2003 | pmid = 12778173 | pmc = 2832179 | doi = 10.1038/ng1170 }}
  • {{cite journal | vauthors = McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S | title = Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism | journal = J. Cell. Biochem. | volume = 89 | issue = 5 | pages = 1005–18 | year = 2003 | pmid = 12874834 | doi = 10.1002/jcb.10548 }}
  • {{cite journal | vauthors = Doan LL, Porter SD, Duan Z, Flubacher MM, Montoya D, Tsichlis PN, Horwitz M, Gilks CB, Grimes HL | title = Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells | journal = Nucleic Acids Res. | volume = 32 | issue = 8 | pages = 2508–19 | year = 2004 | pmid = 15131254 | pmc = 419458 | doi = 10.1093/nar/gkh570 }}
  • {{cite journal | vauthors = Dwivedi PP, Anderson PH, Omdahl JL, Grimes HL, Morris HA, May BK | title = Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells | journal = Endocr. Relat. Cancer | volume = 12 | issue = 2 | pages = 351–65 | year = 2005 | pmid = 15947108 | doi = 10.1677/erc.1.00920 }}
  • {{cite journal | vauthors = Duan Z, Zarebski A, Montoya-Durango D, Grimes HL, Horwitz M | title = Gfi1 Coordinates Epigenetic Repression of p21Cip/WAF1 by Recruitment of Histone Lysine Methyltransferase G9a and Histone Deacetylase 1 | journal = Mol. Cell. Biol. | volume = 25 | issue = 23 | pages = 10338–51 | year = 2005 | pmid = 16287849 | pmc = 1291230 | doi = 10.1128/MCB.25.23.10338-10351.2005 }}
  • {{cite journal | vauthors = Marteijn JA, van der Meer LT, Van Emst L, de Witte T, Jansen JH, van der Reijden BA | title = Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes | journal = Blood | volume = 109 | issue = 1 | pages = 100–8 | year = 2007 | pmid = 16888099 | doi = 10.1182/blood-2006-02-003590 }}
  • {{cite journal | vauthors = Dwivedi PP, Anderson PH, Tilley WD, May BK, Morris HA | title = Role of oncoprotein growth factor independent-1 (GFI1) in repression of 25-hydroxyvitamin D 1alpha-hydroxylase (CYP27B1): a comparative analysis in human prostate cancer and kidney cells | journal = J. Steroid Biochem. Mol. Biol. | volume = 103 | issue = 3–5 | pages = 742–6 | year = 2007 | pmid = 17207994 | doi = 10.1016/j.jsbmb.2006.12.014 }}
  • {{cite journal | vauthors = Nakazawa Y, Suzuki M, Manabe N, Yamada T, Kihara-Negishi F, Sakurai T, Tenen DG, Iwama A, Mochizuki M, Oikawa T | title = Cooperative interaction between ETS1 and GFI1 transcription factors in the repression of Bax gene expression | journal = Oncogene | volume = 26 | issue = 24 | pages = 3541–50 | year = 2007 | pmid = 17213822 | doi = 10.1038/sj.onc.1210140 }}
  • {{cite journal | vauthors = Khanna-Gupta A, Sun H, Zibello T, Lee HM, Dahl R, Boxer LA, Berliner N | title = Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBPϵ gene | journal = Blood | volume = 109 | issue = 10 | pages = 4181–90 | year = 2007 | pmid = 17244686 | pmc = 1885490 | doi = 10.1182/blood-2005-05-022004 }}
  • {{cite journal | vauthors = Marteijn JA, van der Meer LT, van Emst L, van Reijmersdal S, Wissink W, de Witte T, Jansen JH, Van der Reijden BA | title = Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1 | journal = Blood | volume = 110 | issue = 9 | pages = 3128–35 | year = 2007 | pmid = 17646546 | doi = 10.1182/blood-2006-11-058602 }}
{{refend}}

External links

  • {{MeshName|GFI1+protein,+human}}
{{NLM content}}{{Transcription factors|g2}}{{DEFAULTSORT:Gfi1}}{{gene-1-stub}}

1 : Transcription factors

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