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词条 GGL domain
释义

  1. Human proteins containing this domain

  2. See also

  3. References

  4. Further reading

{{Pfam_box
| Symbol = G-gamma
| Name =
| image =1b9x_opm.png
| width =250
| caption =Phosducin - transducin beta-gamma complex. Gamma subunit (GGL domain) colored red.
| Pfam= PF00631
| InterPro= IPR001770
| SMART= GGL
| PROSITE = PDOC01002
| SCOP = 1gp2
| TCDB =
| OPM family=
| OPM protein= 2bcj
| CDD = cd00068
| PDB={{PDB3|2bcj}}G:9-63 {{PDB3|1xhm}}B:9-63 {{PDB3|1omw}}G:9-63{{PDB3|1gp2}}G:9-60 {{PDB3|1gg2}}G:9-60 {{PDB3|2trc}}G:12-66{{PDB3|1tbg}}F:12-66 {{PDB3|1b9y}}B:12-66 {{PDB3|1b9x}}B:12-66{{PDB3|1got}}G:12-65 {{PDB3|1mf6}}A:59-66
}}GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.[1]

Human proteins containing this domain

  • GNG4; GNG10; GNG11
  • GNGT1
  • RGS6; RGS7; RGS9; RGS11

See also

  • Beta-gamma complex

References

1. ^{{cite journal |vauthors=Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP | title = A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 22 | pages = 13307–12 | year = 1998 | pmid = 9789084 | doi = 10.1073/pnas.95.22.13307 | pmc = 23793 }}

Further reading

  • {{cite journal |vauthors=Chatterjee TK, Liu Z, Fisher RA |title=Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants |journal=J. Biol. Chem. |volume=278 |issue=32 |pages=30261–71 |date=August 2003 |pmid=12761221 |doi=10.1074/jbc.M212687200 |url=}}
  • {{cite journal |vauthors=Chen CK, Eversole-Cire P, Zhang H |title=Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue=11 |pages=6604–9 |date=May 2003 |pmid=12738888 |pmc=164494 |doi=10.1073/pnas.0631825100 |url=|display-authors=etal}}
  • {{cite journal |vauthors=Liu Z, Chatterjee TK, Fisher RA |title=RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6 |journal=J. Biol. Chem. |volume=277 |issue=40 |pages=37832–9 |date=October 2002 |pmid=12140291 |doi=10.1074/jbc.M205908200 |url=}}
{{membrane-protein-stub}}

2 : Protein domains|Peripheral membrane proteins

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