“Glutamine—phenylpyruvate transaminase”的意思、由来-开放百科全书

词条

Glutamine—phenylpyruvate transaminase

释义

Structural studies
References

{{enzyme
| Name = glutamine-phenylpyruvate transaminase
| EC_number = 2.6.1.64
| CAS_number = 68518-06-9
| IUBMB_EC_number = 2/6/1/64
| GO_code = 0047316
| image =
| width =
| caption =
}}

In enzymology, a glutamine-phenylpyruvate transaminase ({{EC number|2.6.1.64}}) is an enzyme that catalyzes the chemical reaction

L-glutamine + phenylpyruvate 2-oxoglutaramate + L-phenylalanine

Thus, the two substrates of this enzyme are L-glutamine and phenylpyruvate, whereas its two products are 2-oxoglutaramate and L-phenylalanine.

This enzyme belongs to the family of transferases, to be specific, the transaminases, that transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:phenylpyruvate aminotransferase. Other names in common use include glutamine transaminase K, and glutamine-phenylpyruvate aminotransferase. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1YIY}} and {{PDB link|1YIZ}}.

References

{{cite journal | author = Cooper AJ | year = 1978 | title = Purification of soluble and mitochondrial glutamine transaminase K from rat kidney. Use of a sensitive assay involving transamination between L-phenylalanine and alpha-keto-gamma-methiolbutyrate | journal = Anal. Biochem. | volume = 89 | pages = 451–60 | pmid = 727444 | doi = 10.1016/0003-2697(78)90374-3 | issue = 2 }}
{{cite journal | vauthors = Cooper AJ, Meister A | year = 1974 | title = Isolation and properties of a new glutamine transaminase from rat kidney | journal = J. Biol. Chem. | volume = 249 | pages = 2554–61 | pmid = 4822504 | issue = 8 }}

{{Nitrogenous transferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{2.6-enzyme-stub}}{{DEFAULTSORT:Glutamine-phenylpyruvate transaminase}}

3 : EC 2.6.1|Pyridoxal phosphate enzymes|Enzymes of known structure

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