“Glutamine—pyruvate transaminase”的意思、由来-开放百科全书

词条

Glutamine—pyruvate transaminase

释义

Structural studies
References

{{enzyme
| Name = glutamine-pyruvate transaminase
| EC_number = 2.6.1.15
| CAS_number = 9030-44-8
| IUBMB_EC_number = 2/6/1/15
| GO_code = 0047945
| image =
| width =
| caption =
}}

In enzymology, a glutamine-pyruvate transaminase ({{EC number|2.6.1.15}}) is an enzyme that catalyzes the chemical reaction

L-glutamine + pyruvate 2-oxoglutaramate + L-alanine

Thus, the two substrates of this enzyme are L-glutamine and pyruvate, whereas its two products are 2-oxoglutaramate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:pyruvate aminotransferase. Other names in common use include glutaminase II, L-glutamine transaminase L, and glutamine-oxo-acid transaminase. This enzyme participates in glutamate metabolism. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1V2D}}, {{PDB link|1V2E}}, and {{PDB link|1V2F}}.

2-oxoglutaramate is another name for alpha-ketoglutarate. So when 2-oxoglutaramate is mentioned as a product of this enzyme is also just saying it produces alpha-ketoglutarate.

References

{{cite journal | vauthors = Cooper JL, Meister A | year = 1972 | title = Isolation and properties of highly purified glutamine transaminase | journal = Biochemistry | volume = 11 | pages = 661–71 | pmid = 5059882 | doi = 10.1021/bi00755a001 | issue = 5 }}
{{cite journal | author = MEISTER A | year = 1954 | title = Studies on the mechanism and specificity of the glutamine-alpha-keto acid transamination-deamidation reaction | journal = J. Biol. Chem. | volume = 210 | pages = 17–35 | pmid = 13201566 | issue = 1 }}

{{Nitrogenous transferases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{DEFAULTSORT:Glutamine-pyruvate transaminase}}{{2.6-enzyme-stub}}

3 : EC 2.6.1|Pyridoxal phosphate enzymes|Enzymes of known structure

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