“Glutaryl-7-aminocephalosporanic-acid acylase”的意思、由来-开放百科全书

词条

Glutaryl-7-aminocephalosporanic-acid acylase

释义

References

{{enzyme
| Name = Glutaryl-7-aminocephalosporanic-acid acylase
| EC_number = 3.5.1.93
| CAS_number =
| IUBMB_EC_number = 3/5/1/93
| GO_code =
| image =
| width =
| caption =
}}

In enzymology, a glutaryl-7-aminocephalosporanic-acid acylase ({{EC number|3.5.1.93}}) is an enzyme that catalyzes the chemical reaction

(7R)-7-(4-carboxybutanamido)cephalosporanate + H₂O (7R)-7-aminocephalosporanate + glutarate

Thus, the two substrates of this enzyme are (7R)-7-(4-carboxybutanamido)cephalosporanate and H₂O, whereas its two products are (7R)-7-aminocephalosporanate and glutarate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (7R)-7-(4-carboxybutanamido)cephalosporanate amidohydrolase. Other names in common use include 7beta-(4-carboxybutanamido)cephalosporanic acid acylase, cephalosporin C acylase, glutaryl-7-ACA acylase, CA, GCA, GA, cephalosporin acylase, glutaryl-7-aminocephalosporanic acid acylase, and GL-7-ACA acylase. This enzyme participates in penicillin and cephalosporin biosynthesis.

References

{{cite journal | author = Shimomura K | year = 1995 | title = High-level production, chemical modification and site-directed mutagenesis of a cephalosporin C acylase from Pseudomonas strain N176 | journal = Eur. J. Biochem. | volume = 230 | pages = 773–778 | pmid = 7607251 | doi = 10.1111/j.1432-1033.1995.0773h.x | last2 = Saito | first2 = Y | last3 = Fujimura | first3 = T | last4 = Sasaki | first4 = H | last5 = Noguchi | first5 = Y | last6 = Yamada | first6 = H | last7 = Niwa | first7 = M | last8 = Shimomura | first8 = K | issue = 2 }}
{{cite journal |vauthors=Kinoshita T, Tada T, Saito Y, Ishii Y, Sato A, Murata M | date = | title = Crystallization and preliminary X-ray analysis of cephalosporin C acylase from Pseudomonas sp. strain N176 | journal = Acta Crystallogr. D | volume = 56 | pages = 458–459 | pmid = 10739919 | doi = 10.1107/S0907444900000718 | issue = Pt 4 }}
{{cite journal |vauthors=Monti D, Carrea G, Riva S, Baldaro E, Frare G | year = 2000 | title = Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase | journal = Biotechnol. Bioeng. | volume = 70 | pages = 239–244 | pmid = 10972935 | doi = 10.1002/1097-0290(20001020)70:2<239::AID-BIT13>3.0.CO;2-I | issue = 2 }}
{{cite journal |vauthors=Kwon TH, Rhee S, Lee YS, Park SS, Kim KH | year = 2000 | title = Crystallization and preliminary X-Ray diffraction analysis of glutaryl-7-aminocephalosporanic acid acylase from Pseudomonas sp GK16 | journal = J. Struct. Biol. | volume = 131 | pages = 79–81 | pmid = 10945972 | doi = 10.1006/jsbi.2000.4256 | issue = 1 }}
{{cite journal |vauthors=Kim Y, Yoon K, Khang Y, Turley S, Hol WG | year = 2000 | title = The 2.0 A crystal structure of cephalosporin acylase | journal = Structure. Fold. Des. | volume = 8 | pages = 1059–1068 | pmid = 11080627 | doi = 10.1016/S0969-2126(00)00505-0 | issue = 10 }}
{{cite journal | author = G | year = 2002 | title = Affinity alkylation of the Trp-B4 residue of the beta -subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp 130 | journal = J. Biol. Chem. | volume = 277 | pages = 10256–10264 | pmid = 11782466 | doi = 10.1074/jbc.M108683200 | last2 = Zeng | first2 = R | last3 = Ding | first3 = X | last4 = Mao | first4 = X | last5 = Ding | first5 = Y | last6 = Rao | first6 = Z | last7 = Xie | first7 = Y | last8 = Jiang | first8 = W | last9 = Zhao | first9 = G | issue = 12 }}
{{cite journal |vauthors=Kim JK, Yang IS, Rhee S, Dauter Z, Lee YS, Park SS, Kim KH | year = 2003 | title = Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: insight into autoproteolytic activation | journal = Biochemistry | volume = 42 | pages = 4084–4093 | pmid = 12680762 | doi = 10.1021/bi027181x | issue = 14 }}

{{Carbon-nitrogen non-peptide hydrolases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{3.5-enzyme-stub}}

2 : EC 3.5.1|Enzymes of unknown structure

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