“Glutathione gamma-glutamylcysteinyltransferase”的意思、由来-开放百科全书

词条

Glutathione gamma-glutamylcysteinyltransferase

释义

Structural studies
References

{{enzyme
| Name = glutathione gamma-glutamylcysteinyltransferase
| EC_number = 2.3.2.15
| CAS_number = 125390-02-5
| IUBMB_EC_number = 2/3/2/15
| GO_code = 0016756
| image =
| width =
| caption =
}}

In enzymology, a glutathione gamma-glutamylcysteinyltransferase ({{EC number|2.3.2.15}}) is an enzyme that catalyzes the chemical reaction

glutathione + [Glu(-Cys)]n-Gly Gly + [Glu(-Cys)]n⁺1-Gly

Thus, the two substrates of this enzyme are glutathione and [Glu(-Cys)]n-Gly, whereas its two products are Gly and [Glu(-Cys)]n+1-Gly.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase. Other names in common use include phytochelatin synthase, and gamma-glutamylcysteine dipeptidyl transpeptidase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|2BTW}} and {{PDB link|2BU3}}.

References

{{cite journal | vauthors = Grill E, Loffler S, ((Winnacker E-L)), Zenk MH | date = 1989 | title = Phytochelatins, the heavy-metal-binding peptides of plants, are synthesized from glutathione by a specific gamma-glutamylcysteine dipeptidyl transpeptidase (phytochelatin synthase) | journal = Proc. Natl. Acad. Sci. USA | volume = 86 | pages = 6838–6842 | doi = 10.1073/pnas.86.18.6838 | issue = 18 | pmc = 297945 }}

2 : EC 2.3.2|Enzymes of known structure

随便看

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。