“Glycerol-3-phosphate O-acyltransferase”的意思、由来-开放百科全书

词条

Glycerol-3-phosphate O-acyltransferase

释义

Structural studies
References

{{enzyme
| Name = glycerol-3-phosphate O-acyltransferase
| EC_number = 2.3.1.15
| CAS_number = 9029-96-3
| IUBMB_EC_number = 2/3/1/15
| GO_code = 0004366
| image =
| width =
| caption =
}}

In enzymology, a glycerol-3-phosphate O-acyltransferase ({{EC number|2.3.1.15}}) is an enzyme that catalyzes the chemical reaction

acyl-CoA + sn-glycerol 3-phosphate CoA + 1-acyl-sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are acyl-CoA and sn-glycerol 3-phosphate, whereas its two products are CoA and 1-acyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase. Other names in common use include alpha-glycerophosphate acyltransferase, 3-glycerophosphate acyltransferase, ACP:sn-glycerol-3-phosphate acyltransferase, glycerol 3-phosphate acyltransferase, glycerol phosphate acyltransferase, glycerol phosphate transacylase, glycerophosphate acyltransferase, glycerophosphate transacylase, sn-glycerol 3-phosphate acyltransferase, and sn-glycerol-3-phosphate acyltransferase. This enzyme participates in glycerolipid metabolism and glycerophospholipid metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1IUQ}} and {{PDB link|1K30}}.

References

{{cite journal |author1 = Bertrams M |author2 =Heinz E | year = 1981 | title = Positional Specificity and Fatty Acid Selectivity of Purified sn-Glycerol 3-Phosphate Acyltransferases from Chloroplasts | journal = Plant Physiol. | volume = 68 | pages = 653–657 | doi = 10.1104/pp.68.3.653 | pmid=16661974 | issue = 3 | pmc = 425956}}
{{cite journal | doi = 10.1111/j.1432-1033.1983.tb07096.x | vauthors = Frentzen M, Heinz E, McKeon TA, Stumpf PK | year = 1983 | title = Specificities and selectivities of glycerol-3-phosphate acyltransferase and monoacylglycerol-3-phosphate acyltransferase from pea and spinach chloroplasts | journal = Eur. J. Biochem. | volume = 129 | pages = 629–36 | pmid = 6825679 | issue = 3 }}
{{cite journal | vauthors = Green PR, Vanaman TC, Modrich P, Bell RM | year = 1983 | title = Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase | journal = J. Biol. Chem. | volume = 258 | pages = 10862–6 | pmid = 6350296 | issue = 18 }}
{{cite journal | vauthors = Yamashita S, Numa S | year = 1972 | title = Partial purification and properties of glycerophosphate acyltransferase from rat liver. Formation of 1-acylglycerol 3-phosphate from sn-glycerol 3-phosphate and palmityl coenzyme A | journal = Eur. J. Biochem. | volume = 31 | pages = 565–73 | pmid = 4650158 | doi = 10.1111/j.1432-1033.1972.tb02566.x | issue = 3 }}

2 : EC 2.3.1|Enzymes of known structure

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