1. Function

2. Clinical significance

3. See also

4. References

5. Further reading

Function

The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha and beta subunits. The GLRB gene encodes the beta subunit of the receptor.^[3]

Clinical significance

Mutations in the gene have been associated with hyperekplexia, a neurologic syndrome associated with an exaggerated startle reaction.^[4][5]

See also

• Glycine receptor
• Stiff person syndrome
• Hyperekplexia

References

Further reading

• {{cite journal |vauthors=Ruiz-Gómez A, Vaello ML, Valdivieso F, Mayor F |title=Phosphorylation of the 48-kDa subunit of the glycine receptor by protein kinase C |journal=J. Biol. Chem. |volume=266 |issue= 1 |pages= 559–66 |year= 1991 |pmid= 1845981 |doi= }}
• {{cite journal |vauthors=Grenningloh G, Schmieden V, Schofield PR, Seeburg PH, Siddique T, Mohandas TK, Becker CM, Betz H |title=Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes |journal=EMBO J. |volume=9 |issue= 3 |pages= 771–6 |year= 1990 |pmid= 2155780 | pmc=551735 |doi= }}
• {{cite journal |vauthors=Langosch D, Herbold A, Schmieden V, Borman J, Kirsch J |title=Importance of Arg-219 for correct biogenesis of alpha 1 homooligomeric glycine receptors |journal=FEBS Lett. |volume=336 |issue= 3 |pages= 540–4 |year= 1994 |pmid= 7506679 |doi=10.1016/0014-5793(93)80872-R }}
• {{cite journal |vauthors=Shiang R, Ryan SG, Zhu YZ, Fielder TJ, Allen RJ, Fryer A, Yamashita S, O'Connell P, Wasmuth JJ |title=Mutational analysis of familial and sporadic hyperekplexia |journal=Ann. Neurol. |volume=38 |issue= 1 |pages= 85–91 |year= 1995 |pmid= 7611730 |doi= 10.1002/ana.410380115 }}
• {{cite journal |vauthors=Baker E, Sutherland GR, Schofield PR |title=Localization of the glycine receptor alpha 1 subunit gene (GLRA1) to chromosome 5q32 by FISH |journal=Genomics |volume=22 |issue= 2 |pages= 491–3 |year= 1995 |pmid= 7806244 |doi= 10.1006/geno.1994.1419 }}
• {{cite journal |vauthors=Rees MI, Andrew M, Jawad S, Owen MJ |title=Evidence for recessive as well as dominant forms of startle disease (hyperekplexia) caused by mutations in the alpha 1 subunit of the inhibitory glycine receptor |journal=Hum. Mol. Genet. |volume=3 |issue= 12 |pages= 2175–9 |year= 1995 |pmid= 7881416 |doi=10.1093/hmg/3.12.2175 }}
• {{cite journal |vauthors=Ryan SG, Buckwalter MS, Lynch JW, Handford CA, Segura L, Shiang R, Wasmuth JJ, Camper SA, Schofield P, O'Connell P |title=A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse |journal=Nat. Genet. |volume=7 |issue= 2 |pages= 131–5 |year= 1994 |pmid= 7920629 |doi= 10.1038/ng0694-131 }}
• {{cite journal |vauthors=Langosch D, Laube B, Rundström N, Schmieden V, Bormann J, Betz H |title=Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia |journal=EMBO J. |volume=13 |issue= 18 |pages= 4223–8 |year= 1994 |pmid= 7925268 | pmc=395349 |doi= }}
• {{cite journal |vauthors=Schorderet DF, Pescia G, Bernasconi A, Regli F |title=An additional family with Startle disease and a G1192A mutation at the alpha 1 subunit of the inhibitory glycine receptor gene |journal=Hum. Mol. Genet. |volume=3 |issue= 7 |pages= 1201 |year= 1995 |pmid= 7981700 |doi=10.1093/hmg/3.7.1201 }}
• {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
• {{cite journal |vauthors=Bormann J, Rundström N, Betz H, Langosch D |title=Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers |journal=EMBO J. |volume=13 |issue= 6 |pages= 1493 |year= 1994 |pmid= 8137830 | pmc=394970 |doi= }}
• {{cite journal |vauthors=Milani N, Dalprá L, del Prete A, Zanini R, Larizza L |title=A novel mutation (Gln266-->His) in the alpha 1 subunit of the inhibitory glycine-receptor gene (GLRA1) in hereditary hyperekplexia |journal=Am. J. Hum. Genet. |volume=58 |issue= 2 |pages= 420–2 |year= 1996 |pmid= 8571969 | pmc=1914546 |doi= }}
• {{cite journal |vauthors=Brune W, Weber RG, Saul B, von Knebel Doeberitz M, Grond-Ginsbach C, Kellerman K, Meinck HM, Becker CM |title=A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors |journal=Am. J. Hum. Genet. |volume=58 |issue= 5 |pages= 989–97 |year= 1996 |pmid= 8651283 | pmc=1914607 |doi= }}
• {{cite journal |vauthors=Elmslie FV, Hutchings SM, Spencer V, Curtis A, Covanis T, Gardiner RM, Rees M |title=Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis |journal=J. Med. Genet. |volume=33 |issue= 5 |pages= 435–6 |year= 1996 |pmid= 8733061 | pmc=1050620 |doi=10.1136/jmg.33.5.435 }}
• {{cite journal |vauthors=Monani U, Burghes AH |title=Structure of the human alpha 2 subunit gene of the glycine receptor--use of vectorette and Alu-exon PCR |journal=Genome Res. |volume=6 |issue= 12 |pages= 1200–6 |year= 1997 |pmid= 8973915 |doi=10.1101/gr.6.12.1200 }}
• {{cite journal |vauthors=Seri M, Bolino A, Galietta LJ, Lerone M, Silengo M, Romeo G |title=Startle disease in an Italian family by mutation (K276E): The alpha-subunit of the inhibiting glycine receptor |journal=Hum. Mutat. |volume=9 |issue= 2 |pages= 185–7 |year= 1997 |pmid= 9067762 |doi= 10.1002/(SICI)1098-1004(1997)9:2<185::AID-HUMU14>3.0.CO;2-Z }}
• {{cite journal |vauthors=Vergouwe MN, Tijssen MA, Shiang R, van Dijk JG, al Shahwan S, Ophoff RA, Frants RR |title=Hyperekplexia-like syndromes without mutations in the GLRA1 gene |journal=Clinical Neurology and Neurosurgery |volume=99 |issue= 3 |pages= 172–8 |year= 1998 |pmid= 9350397 |doi=10.1016/S0303-8467(97)00022-X }}
• {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}

• British European Airways Flight 284
• British European Airways Flight 411
• British European Airways Flight S200P
• British Evangelical Council
• British Everest Expedition
• British ex-pat community
• British expatriate
• British expedition against Cuba
• British expedition against dominica
• British expedition against Guadeloupe
• British Expeditionary Force
• British Expeditionary Force (1914)
• British Expeditionary Force (disambiguation)
• British Expeditionary Force order of battle (1914)
• British Expeditionary Force (World War II)
• British expedition to ceylon
• British expedition to tibet
• British expedition to Tibet (1903-1904)
• British Experimental Rotor Program
• British Experimental Rotor Programme
• British Expertise
• British Families Education Service
• British farming
• British Fascism 1918-39
• British Fashion Council