1. References

In enzymology, a glycoprotein 2-beta-D-xylosyltransferase ({{EC number|2.4.2.38}}) is an enzyme that catalyzes the chemical reaction

UDP-D-xylose + N₄-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D- mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D- glucosaminyl}asparagine UDP + N₄-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N- acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D- xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl- (1->4)-N-acetyl-beta-D-glucosaminyl}asparagine

The 5 substrates of this enzyme are UDP-D-xylose, {N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-">N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-, 2)-alpha-D-mannosyl-(1->6)]-beta-D-">acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-, 4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-">mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-, and glucosaminyl}asparagine, whereas its 5 products are UDP, {N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-">N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-, 2)-alpha-D-mannosyl-(1->6)">acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)-beta-D-, 2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-">xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-, and 4)-N-acetyl-beta-D-glucosaminyl}asparagine">(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-a cetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-man nosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glu cosaminyl}asparagine) 2-beta-D-xylosyltransferase. Other names in common use include beta1,2-xylosyltransferase, UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose, of, 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-, acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-, mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-, and glucosaminyl}asparagine) 2-beta-D-xylosyltransferase. This enzyme participates in glycan structures - biosynthesis 1.

References

• {{cite journal | vauthors = Zeng Y, Bannon G, Thomas VH, Rice K, Drake R, Elbein A | year = 1997 | title = Purification and specificity of beta1,2-xylosyltransferase, an enzyme that contributes to the allergenicity of some plant proteins | journal = J. Biol. Chem. | volume = 272 | pages = 31340–7 | pmid = 9395463 | doi = 10.1074/jbc.272.50.31340 | issue = 50 }}
• {{cite journal | author = Steinkellner H | year = 2000 | title = Molecular cloning and functional expression of beta1, 2-xylosyltransferase cDNA from Arabidopsis thaliana | journal = FEBS Lett. | volume = 472 | pages = 105–8 | pmid = 10781814 | doi = 10.1016/S0014-5793(00)01443-5 | last2 = Mucha | first2 = J | last3 = Mach | first3 = L | last4 = Altmann | first4 = F | last5 = Wilson | first5 = IB | last6 = Glössl | first6 = J | last7 = Steinkellner | first7 = H | issue = 1 }}

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